{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:27:01Z","timestamp":1788848821987,"version":"build-2803163510"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173589"],"award-info":[{"award-number":["82173589"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2503605"],"award-info":[{"award-number":["2022YFC2503605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital","award":["NCRCG-PLAGH-2023001"],"award-info":[{"award-number":["NCRCG-PLAGH-2023001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The possible joint association of vitamin D and obesity in regard to clinical biomarker-based biological aging process has not been well studied. We investigated the independent and combined associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations and body mass index (BMI) with phenotypic age (PhenoAge) and Klemera\u2013Doubal method Biological Age (KDM-BA) acceleration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted using data from participants in the UK Biobank baseline survey. Restricted cubic splines and multivariable logistic regression analyses were used to investigate the associations of serum 25(OH)D concentrations and BMI with PhenoAge and KDM-BA acceleration. Mediation analyses were conducted to assess whether biological age acceleration potentially mediated the association between 25(OH)D or BMI and all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In Analysis 1 (n\u2009=\u2009389\u2009217) for PhenoAge, and Analysis 2 for KDM-BA (n\u2009=\u2009329\u2009561), participants whose serum 25(OH)D concentration \u226550.0 nmol\/L or with normal weight (BMI &amp;lt;25 kg\/m2) had the lowest odds of biological age acceleration. Those with both 25(OH)D\u2009&amp;lt;25.0 nmol\/L and BMI \u226530.0 kg\/m2 had the highest odds of PhenoAge acceleration ([OR [95% CI], 2.387 [2.303, 2.474]) and KDM-BA acceleration [OR (95% CI), 4.096 (3.926, 4.274)]. The mediation analysis revealed that PhenoAge acceleration mediated 11.4% and 47.1% of the associations of 25(OH)D and BMI with all-cause mortality; while KDM-BA acceleration accounted for 7.41% and 55.2%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum 25(OH)D concentrations and BMI were significantly associated with the acceleration of biological aging. Combining vitamin D deficiency and obesity demonstrated enhanced synergistic association on the biological aging process, highlighting the importance of vitamin D and BMI in promoting healthy aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glaf215","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:59:44Z","timestamp":1760097584000},"source":"Crossref","is-referenced-by-count":1,"title":["Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging"],"prefix":"10.1093","volume":"81","author":[{"given":"Zimo","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Endocrinology, the Second Medical Center & National Clinical Research Center for Geriatric Disease, Chinese PLA General Hospital , Beijing,","place":["China"]},{"name":"Medical School of Chinese PLA , 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Second Medical Center, Chinese People\u2019s Liberation Army General Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhan","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA , Beijing,","place":["China"]},{"name":"Department of Anti-NBC Medicine, Graduate School, Chinese People\u2019s Liberation Army General Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaihao","family":"Li","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA , Beijing,","place":["China"]},{"name":"Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People\u2019s Liberation Army General Hospital , 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