{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:48:45Z","timestamp":1762782525223,"version":"build-2065373602"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\/NIA R01AG067758","NIH\/NIA R01AG078129"],"award-info":[{"award-number":["NIH\/NIA R01AG067758","NIH\/NIA R01AG078129"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Muscle weakness and poor brain health both contribute to mobility limitations in older adults, but their respective contributions and interactions are not well understood. This study examines the relationship between magnetic resonance imaging-estimated brain-predicted age difference (brain-predicted age\u2212chronological age), leg strength, and their interaction on mobility decline using Baltimore Longitudinal Study of Aging data (N\u2009=\u2009645, 78.1\u2009\u00b1\u20097.54 years, 56% women). Partial Spearman correlations evaluated the relationships between leg strength, brain-predicted age difference (BPAD), gait speed, and time to complete 5 repeated chair stands (5CS). Mixed-effects linear regression models examined associations of baseline BPAD, leg strength, and lifestyle factors with mobility change over time (5.74\u2009\u00b1\u20092.87 years). Logistic regression modeled predictors of success in a narrow course walking task. Leg strength significantly correlated with gait speed (r\u2009=\u20090.26, p\u2009&amp;lt;\u2009.001) and 5CS (r = \u22120.27, p\u2009&amp;lt;\u2009.001). BPAD was associated with decreased gait speed (\u03b2 = \u22120.022, p\u2009=\u2009.011) and slower 5CS (\u03b2\u2009=\u20090.331, p\u2009=\u2009.012). Greater leg strength was associated with preserved gait speed (\u03b2\u2009=\u20090.023, p\u2009=\u2009.022) and faster 5CS (\u03b2 = \u22120.552, p\u2009&amp;lt;\u2009.001). BPAD (OR\u2009=\u20090.712, 95% CI, 0.687-0.940) and leg strength (OR\u2009=\u20090.805, 95% CI, 0.696-0.964) predicted lower likelihood of narrow walk success. Interactions between BPAD and leg strength were not significant for any measure. These findings suggest accelerated brain aging and leg weakness independently contribute to mobility decline, highlighting the need for interventions targeting brain health and muscle strength to preserve mobility in aging populations.<\/jats:p>","DOI":"10.1093\/gerona\/glaf222","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:49:48Z","timestamp":1761133788000},"source":"Crossref","is-referenced-by-count":0,"title":["The predictive power of brain-predicted age and leg strength on mobility decline in aging: findings from the Baltimore Longitudinal Study of Aging"],"prefix":"10.1093","volume":"80","author":[{"given":"Brooke A","family":"Vaughan","sequence":"first","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University , Athens, Ohio,","place":["United States"]},{"name":"Department of Physical Therapy, Ohio University , Athens, Ohio,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Muniz-Terrera","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Ohio University Heritage College of Osteopathic Medicine, Ohio University , Athens, Ohio,","place":["United States"]},{"name":"Edinburgh Dementia Prevention, University of Edinburgh , Edinburgh,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet E","family":"Simon","sequence":"additional","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University , Athens, Ohio,","place":["United States"]},{"name":"College of Health Sciences and Professions, Ohio University , Athens, Ohio,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dustin R","family":"Grooms","sequence":"additional","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University , Athens, Ohio,","place":["United States"]},{"name":"Department of Physical Therapy, Ohio University , Athens, Ohio,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-6431","authenticated-orcid":false,"given":"Brian C","family":"Clark","sequence":"additional","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University , Athens, Ohio,","place":["United States"]},{"name":"Department of Biomedical Sciences, Ohio University Heritage College of Osteopathic Medicine, Ohio University , Athens, Ohio,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-8561","authenticated-orcid":false,"given":"Christos","family":"Davatzikos","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Image Computing and Analytics, University of Pennsylvania , Philadelphia, Pennsylvania,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guray","family":"Erus","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Image Computing and Analytics, University of Pennsylvania , Philadelphia, Pennsylvania,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2706-1439","authenticated-orcid":false,"given":"Qu","family":"Tian","sequence":"additional","affiliation":[{"name":"Intramural Research Program, National Institute on Aging , Baltimore, Maryland,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6273-1613","authenticated-orcid":false,"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Intramural Research Program, National Institute on Aging , Baltimore, Maryland,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M","family":"Resnick","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, National Institute on Aging , Baltimore, Maryland,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-3494","authenticated-orcid":false,"given":"Eleanor M","family":"Simonsick","sequence":"additional","affiliation":[{"name":"Intramural Research Program, National Institute on Aging , Baltimore, Maryland,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"year":"2020","author":"NCHS Data Visualization Gallery. 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