{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:21:30Z","timestamp":1791872490923,"version":"4.3.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Benzodiazepines (BZDs) are commonly used in older populations despite their association with multiple adverse outcomes. However, the impact of continuing versus deprescribing BZDs during hospitalization on short-term mortality after discharge remains uncertain. This study aims to evaluate the association of BZD-use at hospital discharge with 6-month mortality and explore whether in-hospital deprescribing modifies mortality risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective analysis of prospectively collected data from patients (aged 66-101\u2009years) consecutively admitted to an Acute Geriatric Unit. Upon admission, all patients underwent a Comprehensive Geriatric Assessment, including functional status, comorbidities, and medications review. A multivariable Cox regression model was used to evaluate the relationship between 6-month mortality and BZD prescription at hospital discharge (BZD nonusers, BZD at discharge, and BZD deprescribed).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 1375 patients (median age: 85.5 [IQR: 48-77, 55% females]) were included. Following therapeutic reconciliation, the BZD at discharge group was younger (p\u2009=\u2009.029), had lower frailty (p\u2009=\u2009.031), cognitive decline (p\u2009=\u2009.043), and in-hospital delirium (p\u2009&amp;lt;\u2009.001) prevalence than the BZD nonusers and BZD deprescribed groups. The BZD at discharge group (n\u2009=\u2009130) showed a higher risk of all-cause 6-month mortality compared to BZD nonusers (n\u2009=\u20091066) (HR: 1.64; 95% CI: 1.14-2.37). Conversely, patients in whom BZDs were deprescribed during hospitalization (n\u2009=\u2009179) exhibited a similar mortality risk as nonusers (HR: 0.97; 95% CI: 0.68-1.39).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BZDs prescription on hospital discharge was associated with an increased risk of 6-month mortality, whereas deprescription may mitigate this excess risk. Our data suggest that hospitalization may represent an opportunity to safely deprescribe BZDs in a controlled setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glaf260","type":"journal-article","created":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T12:47:53Z","timestamp":1763902073000},"source":"Crossref","is-referenced-by-count":1,"title":["Benzodiazepine exposure and 6-month mortality in older adults post-hospitalization: time to consider deprescribing?"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-0294","authenticated-orcid":false,"given":"Federico","family":"Bellelli","sequence":"first","affiliation":[{"name":"IHU HealthAge , Toulouse,","place":["France"]},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse, Centre Hospitalo-Universitaire de Toulouse , Toulouse,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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