{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:51:23Z","timestamp":1789829483596,"version":"4.0.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Baden-W\u00fcrttemberg state Ministry of Science, Research and Arts"},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While previous research has demonstrated that frailty is associated with increased dementia risk over time, large multi-decade prospective population-based cohort studies remain limited. Furthermore, the association between lower grip strength and blood-based biomarkers of neuropathology and global cognitive function remains under-investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the relationship between varying levels of baseline frailty (measured using a deficit accumulation Frailty Index [FI]) and dementia incidence over 17\u2009years, as well as associations of grip strength (hand, pinch, and key, assessed at 8- and 14-year follow-up) with blood-based biomarkers of neuropathology (year 8) and with global cognitive function (year 14) in a population-representative cohort of 9940 mid- to late-life (50-75\u2009years) individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In a subsample of 6357 participants with available dementia information at 17-year follow-up (mean age at baseline [SD], 61.7 [6.6] years; female, 54.3%), 516 received an all-cause dementia diagnosis. Over this time, individuals in the highest FI quintile demonstrated a significantly higher risk of all-cause dementia (hazard ratio [HR], 1.75; 95% CI, 1.18-2.60) and a vascular dementia diagnosis (HR, 2.44; 95% CI, 1.22-4.91). Cross-sectionally, lower handgrip strength was associated with elevated blood levels of neurofilament light chain (\u03b2 = \u2212.01, p\u2009=\u2009.007) and pTau181 (\u03b2=\u2212.004, p\u2009=\u2009.017) at 8-year follow-up, as well as poorer cognitive function on the Montreal Cognitive Assessment (\u03b2\u2009=\u2009.02, p\u2009=\u2009.042) at 14-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study strengthens evidence that frailty is a risk factor for dementia in mid- to late-life. It also suggests that it is of considerable importance to assess frailty and grip strength in individuals \u201cat risk\u201d of cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glaf268","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T13:32:09Z","timestamp":1764941529000},"source":"Crossref","is-referenced-by-count":1,"title":["Frailty, grip strength, blood-based biomarkers of neuropathology, and incident dementia: a 17-year longitudinal population study"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-8222","authenticated-orcid":false,"given":"Johannes C","family":"Michaelian","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research, German Cancer Research Center , Heidelberg,","place":["Germany"]},{"name":"Healthy Brain Ageing Program, Brain and Mind Centre and Charles Perkins Centre, School of Psychology, Faculty of Science, 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