{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:02:00Z","timestamp":1789761720070,"version":"4.0.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370563"],"award-info":[{"award-number":["82370563"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ7423"],"award-info":[{"award-number":["2024JJ7423"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Outstanding Young Scientific and Technological Talents Project of Dalian","award":["2024RJ018"],"award-info":[{"award-number":["2024RJ018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gut microbiota plays a pivotal role in Parkinson\u2019s disease (PD) pathogenesis. However, the role of enteric viruses remains underexplored. Here, we reanalyzed publicly available metagenomic datasets from two independent cohorts, including 79 PD patients and 79 controls, to characterize gut virome profiles and explore the potential role of enteric viruses in PD pathogenesis and early diagnosis. Our findings indicate increased richness and diversity of the gut virome in PD, with 640 vOTUs differing in abundance between groups. Notably, Siphoviridae and Myoviridae were more abundant in PD patients. A variety of viruses enriched in PD or healthy subjects (HS) preferentially infect bacterial hosts that produce short-chain fatty acids. Furthermore, specific viral functional orthologs, such as thymidylate synthase (K00560) and integrases (K14059), displayed notable differences in prevalence between PD-enriched and HS-enriched vOTUs. Finally, we constructed a random forest model using the top 22 most significant vOTUs, which achieved an AUC of 0.822, demonstrating strong performance in distinguishing PD patients from healthy controls. This is the first study to characterize the gut virome profile in PD, laying a robust foundation for future investigations into the underlying mechanisms and early diagnosis strategies for PD as well as other neurodegenerative disorders.<\/jats:p>","DOI":"10.1093\/gerona\/glag001","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:37:43Z","timestamp":1767875863000},"source":"Crossref","is-referenced-by-count":6,"title":["Alterations of the gut virome in patients with Parkinson\u2019s disease"],"prefix":"10.1093","volume":"81","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Department of Neurology, Intensive Care Unit, Loudi Central Hospital , Loudi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruochun","family":"Guo","sequence":"additional","affiliation":[{"name":"Puensum Genetech Institute , Wuhan,","place":["China"]},{"name":"Center for Microbiome Medicine, The Fifth Affiliated Hospital of Southern Medical University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Department of Biochemistry and Molecular Biology, College of Basic Sciences, Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiulong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Department of Neurology, Intensive Care Unit, Loudi Central Hospital , Loudi,","place":["China"]},{"name":"Center for Microbiome Medicine, The Fifth Affiliated Hospital of Southern Medical University , Guangzhou,","place":["China"]},{"name":"Department of Microbiology, Department of Biochemistry and Molecular Biology, College of Basic Sciences, Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Department of Clinical Laboratory, Department of Scientific Research, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First People\u2019s Hospital of Loudi City , Loudi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Department of Neurology, Intensive Care Unit, Loudi Central Hospital , Loudi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Department of Neurology, Intensive Care Unit, Loudi Central Hospital , Loudi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorui","family":"Xing","sequence":"additional","affiliation":[{"name":"Puensum Genetech Institute , Wuhan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Department of Clinical Laboratory, Department of Scientific Research, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Department of Clinical Laboratory, Department of Scientific Research, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Department of Clinical Laboratory, Department of Scientific Research, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Sha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Department of Biochemistry and Molecular Biology, College of Basic Sciences, Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erning","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Department of Biochemistry and Molecular Biology, College of Basic Sciences, Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Department of Biochemistry and Molecular Biology, College of Basic Sciences, Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Department of Biochemistry and Molecular Biology, College of Basic Sciences, Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengming","family":"Liu","sequence":"additional","affiliation":[{"name":"Puensum Genetech Institute , Wuhan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Lu","sequence":"additional","affiliation":[{"name":"Puensum Genetech Institute , Wuhan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Yu","sequence":"additional","affiliation":[{"name":"Puensum Genetech Institute , Wuhan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Su","sequence":"additional","affiliation":[{"name":"Puensum Genetech Institute , Wuhan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Puensum Genetech Institute , Wuhan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Department of Clinical Laboratory, Department of Scientific Research, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Department of Clinical Laboratory, Department of Scientific Research, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Department of Clinical Laboratory, Department of Scientific Research, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Department of Clinical Laboratory, Department of Scientific Research, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Department of Clinical Laboratory, Department of Scientific Research, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Department of Clinical Laboratory, Department of Scientific Research, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengchun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-8991","authenticated-orcid":false,"given":"Jian","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Department of Biochemistry and Molecular Biology, College of Basic Sciences, Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Department of Neurology, Intensive Care Unit, Loudi Central Hospital , Loudi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"2026022801265944600_glag001-B1","volume-title":"Parkinson disease","author":"Zafar"},{"key":"2026022801265944600_glag001-B2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.tins.2018.09.007","article-title":"Triggers, facilitators, and aggravators: redefining Parkinson\u2019s disease pathogenesis","volume":"42","author":"Johnson","year":"2019","journal-title":"Trends Neurosci"},{"key":"2026022801265944600_glag001-B3","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.3389\/fneur.2019.01155","article-title":"The role of the gut microbiota in the pathogenesis of Parkinson\u2019s disease","volume":"10","author":"Yang","year":"2019","journal-title":"Front Neurol"},{"key":"2026022801265944600_glag001-B4","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/19490976.2019.1638722","article-title":"Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health","volume":"11","author":"Parker","year":"2020","journal-title":"Gut Microbes"},{"key":"2026022801265944600_glag001-B5","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The gut microbiota-brain axis in behaviour and brain disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"2026022801265944600_glag001-B6","doi-asserted-by":"publisher","first-page":"2102878","DOI":"10.1080\/19490976.2022.2102878","article-title":"Microbiota-derived metabolites as drivers of gut-brain communication","volume":"14","author":"Ahmed","year":"2022","journal-title":"Gut Microbes"},{"key":"2026022801265944600_glag001-B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119577","article-title":"Neurodegenerative and neurodevelopmental diseases and the gut-brain axis: the potential of therapeutic targeting of the microbiome","volume":"24","author":"Bicknell","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026022801265944600_glag001-B8","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1007\/s00415-019-09320-1","article-title":"Parkinson\u2019s disease and the gastrointestinal microbiome","volume":"267","author":"Lubomski","year":"2020","journal-title":"J Neurol"},{"key":"2026022801265944600_glag001-B9","doi-asserted-by":"publisher","first-page":"728479","DOI":"10.3389\/fmicb.2021.728479","article-title":"Cross-sectional study on the gut microbiome of Parkinson\u2019s disease patients in central China","volume":"12","author":"Mao","year":"2021","journal-title":"Front Microbiol"},{"key":"2026022801265944600_glag001-B10","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1002\/mds.28119","article-title":"Meta-analysis of gut dysbiosis in Parkinson\u2019s disease","volume":"35","author":"Nishiwaki","year":"2020","journal-title":"Mov Disord"},{"key":"2026022801265944600_glag001-B11","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson\u2019s disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"2026022801265944600_glag001-B12","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13024-024-00766-0","article-title":"Gut-first Parkinson\u2019s disease is encoded by gut dysbiome","volume":"19","author":"Munoz-Pinto","year":"2024","journal-title":"Mol Neurodegener"},{"key":"2026022801265944600_glag001-B13","doi-asserted-by":"publisher","first-page":"e22035","DOI":"10.1097\/md.0000000000022035","article-title":"Fecal microbiota transplantation therapy for Parkinson\u2019s disease: a preliminary study","volume":"99","author":"Xue","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"2026022801265944600_glag001-B14","doi-asserted-by":"publisher","first-page":"1347987","DOI":"10.3389\/fnagi.2024.1347987","article-title":"The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets","volume":"16","author":"Adamu","year":"2024","journal-title":"Front Aging Neurosci"},{"key":"2026022801265944600_glag001-B15","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","article-title":"Role of neuroinflammation in neurodegeneration development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026022801265944600_glag001-B16","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026022801265944600_glag001-B17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s13195-023-01285-8","article-title":"A metagenomic study of gut viral markers in amyloid-positive Alzheimer\u2019s disease patients","volume":"15","author":"Ghorbani","year":"2023","journal-title":"Alzheimers Res Ther"},{"key":"2026022801265944600_glag001-B18","doi-asserted-by":"publisher","first-page":"10812","DOI":"10.1038\/s41598-020-69086-9","article-title":"Parkinson\u2019s disease and bacteriophages as its overlooked contributors","volume":"8","author":"Tetz","year":"2018","journal-title":"Sci Rep"},{"key":"2026022801265944600_glag001-B19","doi-asserted-by":"publisher","first-page":"11472","DOI":"10.3390\/ijms252111472","article-title":"Longitudinal and multi-kingdom gut microbiome alterations in a mouse model of Alzheimer\u2019s disease","volume":"25","author":"Zhang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026022801265944600_glag001-B20","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.tim.2018.05.009","article-title":"Close encounters of three kinds: bacteriophages, commensal bacteria, and host immunity","volume":"26","author":"Keen","year":"2018","journal-title":"Trends Microbiol"},{"key":"2026022801265944600_glag001-B21","doi-asserted-by":"publisher","DOI":"10.3791\/64945","article-title":"Understanding the impact of temperate bacteriophages on their lysogens through transcriptomics","volume":"5","author":"Krishnamurthi","year":"2024","journal-title":"J Vis Exp"},{"key":"2026022801265944600_glag001-B22","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1093\/brain\/awaa310","article-title":"Gut metagenomics-derived genes as potential biomarkers of Parkinson\u2019s disease","volume":"143","author":"Qian","year":"2020","journal-title":"Brain"},{"key":"2026022801265944600_glag001-B23","doi-asserted-by":"publisher","author":"Li","DOI":"10.1101\/2022.12.27.522048"},{"key":"2026022801265944600_glag001-B24","doi-asserted-by":"publisher","first-page":"104418","DOI":"10.1016\/j.isci.2022.104418","article-title":"A catalog of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome","volume":"25","author":"Li","year":"2022","journal-title":"iScience"},{"key":"2026022801265944600_glag001-B25","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41522-024-00567-9","article-title":"A population-scale analysis of 36 gut microbiome studies reveals universal species signatures for common diseases","volume":"10","author":"Sun","year":"2024","journal-title":"NPJ Biofilms Microbiomes"},{"key":"2026022801265944600_glag001-B26","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1658\/1100-9233","article-title":"VEGAN, a package of R functions for community ecology","volume":"14","author":"Dixon","year":"2003","journal-title":"J Veg. Sci"},{"key":"2026022801265944600_glag001-B27","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"J BMC Bioinformatics"},{"key":"2026022801265944600_glag001-B28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41531-022-00351-6","article-title":"Oral and gut dysbiosis leads to functional alterations in Parkinson\u2019s disease","volume":"8","author":"Jo","year":"2022","journal-title":"NPJ Parkinsons Dis"},{"key":"2026022801265944600_glag001-B29","doi-asserted-by":"publisher","first-page":"6958","DOI":"10.1038\/s41467-022-34667-x","article-title":"Metagenomics of Parkinson\u2019s disease implicates the gut microbiome in multiple disease mechanisms","volume":"13","author":"Wallen","year":"2022","journal-title":"Nat Commun"},{"key":"2026022801265944600_glag001-B30","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1007\/s00705-021-05156-1","article-title":"Changes to virus taxonomy and to the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2021)","volume":"166","author":"Walker","year":"2021","journal-title":"Arch Virol"},{"key":"2026022801265944600_glag001-B31","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.chom.2022.01.013","article-title":"Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans","volume":"30","author":"Mayneris-Perxachs","year":"2022","journal-title":"Cell Host Microbe"},{"key":"2026022801265944600_glag001-B32","doi-asserted-by":"publisher","DOI":"10.3390\/nu15040977","article-title":"The human gut virome and its relationship with nontransmissible chronic diseases","volume":"15","author":"Ezzatpour","year":"2023","journal-title":"Nutrients"},{"key":"2026022801265944600_glag001-B33","doi-asserted-by":"crossref","first-page":"102900","DOI":"10.1016\/j.isci.2021.102900","article-title":"Gut dsDNA virome shows diversity and richness alterations associated with childhood obesity and metabolic syndrome","volume":"24","author":"Bikel","year":"2021","journal-title":"iScience"},{"key":"2026022801265944600_glag001-B34","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1186\/s12883-024-03820-y","article-title":"Association between metabolic syndrome and the risk of Parkinson\u2019s disease: a meta-analysis","volume":"24","author":"Zhong","year":"2024","journal-title":"BMC Neurol"},{"key":"2026022801265944600_glag001-B35","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12902-024-01623-3","article-title":"Association of metabolic syndrome and its components with Parkinson\u2019s disease: a cross-sectional study","volume":"24","author":"Shi","year":"2024","journal-title":"BMC Endocr Disord"},{"key":"2026022801265944600_glag001-B36","doi-asserted-by":"publisher","first-page":"2390720","DOI":"10.1080\/19490976.2024.2390720","article-title":"Role of bacteriophages in shaping gut microbial community","volume":"16","author":"Mahmud","year":"2024","journal-title":"Gut Microbes"},{"key":"2026022801265944600_glag001-B37","doi-asserted-by":"publisher","first-page":"111661","DOI":"10.1016\/j.biopha.2021.111661","article-title":"Role of microbiota-derived short-chain fatty acids in nervous system disorders","volume":"139","author":"Mirzaei","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"2026022801265944600_glag001-B38","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.3748\/wjg.v21.i9.2759","article-title":"Fecal microbes, short chain fatty acids, and colorectal cancer across racial\/ethnic groups","volume":"21","author":"Hester","year":"2015","journal-title":"World J Gastroenterol"},{"key":"2026022801265944600_glag001-B39","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.1038\/s41564-024-01858-9","article-title":"Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts","volume":"9","author":"Manghi","year":"2024","journal-title":"Nat Microbiol"},{"key":"2026022801265944600_glag001-B40","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bbb\/zbaa110","article-title":"Three main short-chain fatty acids inhibit the activation of THP-1 cells by mycoplasma pneumoniae","volume":"85","author":"Wen","year":"2021","journal-title":"Biosci Biotechnol Biochem"},{"key":"2026022801265944600_glag001-B41","doi-asserted-by":"publisher","DOI":"10.3390\/foods11182863","article-title":"Health benefits and side effects of short-chain fatty acids","volume":"11","author":"Xiong","year":"2022","journal-title":"Foods"},{"key":"2026022801265944600_glag001-B42","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1053\/j.gastro.2010.01.053","article-title":"Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats","volume":"138","author":"Soret","year":"2010","journal-title":"Gastroenterology"},{"key":"2026022801265944600_glag001-B43","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1038\/ncomms4611","article-title":"The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism","volume":"5","author":"Frost","year":"2014","journal-title":"Nat Commun"},{"key":"2026022801265944600_glag001-B44","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/cns.13990","article-title":"Gut bacterial profiles in Parkinson\u2019s disease: a systematic review","volume":"29","author":"Li","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"2026022801265944600_glag001-B45","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1177\/1073858415579635","article-title":"DNA methylation in memory formation: emerging insights","volume":"21","author":"Heyward","year":"2015","journal-title":"Neuroscientist"},{"key":"2026022801265944600_glag001-B46","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s00401-019-01993-2","article-title":"Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity","volume":"137","author":"Hu","year":"2019","journal-title":"Acta Neuropathol"},{"key":"2026022801265944600_glag001-B47","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/978-1-4419-7002-2_9","article-title":"Mitochondrial protein quality control systems in aging and disease","volume":"694","author":"Luce","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"2026022801265944600_glag001-B48","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.virol.2010.12.008","article-title":"Structural biology of retroviral DNA integration","volume":"411","author":"Li","year":"2011","journal-title":"Virology"},{"key":"2026022801265944600_glag001-B49","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00702-019-02001-3","article-title":"Biomarkers of Parkinson\u2019s disease: 20 years later","volume":"126","author":"Yilmaz","year":"2019","journal-title":"J Neural Transm (Vienna)"},{"key":"2026022801265944600_glag001-B50","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.biopha.2018.05.026","article-title":"Candidate biomarkers for Parkinson\u2019s disease","volume":"104","author":"Khodadadian","year":"2018","journal-title":"Biomed Pharmacother"}],"container-title":["The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/advance-article-pdf\/doi\/10.1093\/gerona\/glag001\/66381947\/glag001.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/81\/3\/glag001\/66381947\/glag001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/81\/3\/glag001\/66381947\/glag001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T06:27:04Z","timestamp":1772260024000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article\/doi\/10.1093\/gerona\/glag001\/8423470"}},"subtitle":[],"editor":[{"given":"Gustavo","family":"Duque","sequence":"additional","affiliation":[{"name":"(Biological Sciences Section)"}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2,5]]}},"URL":"https:\/\/doi.org\/10.1093\/gerona\/glag001","relation":{},"ISSN":["1079-5006","1758-535X"],"issn-type":[{"value":"1079-5006","type":"print"},{"value":"1758-535X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,2,5]]},"article-number":"glag001"}}