{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T05:01:01Z","timestamp":1771218061962,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Heterochronic plasma exchange is widely used to investigate systemic aging; however, its pulmonary consequences particularly regarding oxidative stress, antioxidant defense, and tissue architecture have not been systematically examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-four-month-old male Sprague\u2013Dawley rats received 0.5\u2009mL of young plasma intravenously daily for 30 days, while 8-week-old rats received 0.25\u2009mL of aged plasma. After treatment, lung tissues were analyzed histologically, biochemically, and molecularly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Quantitative PCR showed that young plasma markedly upregulated antioxidant defenses, with SOD and CAT expression increasing by \u223c2.5-fold and 1.8-fold, respectively (p\u2009&amp;lt;\u20090.01), accompanied by higher SOD and GPX enzyme activities (p\u2009&amp;lt;\u20090.05). Additional antioxidant genes (GR, GST, TXN\/TXNR) were also significantly upregulated, confirming a broad activation of the antioxidant network. In contrast, aged plasma suppressed antioxidant responses, reducing CAT activity by \u223c35% (p\u2009&amp;lt;\u20090.01) and similarly decreasing other enzymes. Histological analyses revealed preserved alveolar structure, thinner septa, and reduced inflammation in old + young plasma rats, while young + old plasma transfer caused structural deterioration. Immunohistochemistry confirmed increased GPX, SOD, and CAT expression in aged rats receiving young plasma, consistent with transcriptional and protein-level activation. Moreover, heterochronic plasma exchange attenuated collagen accumulation, suggesting reduced fibrillar matrix deposition, and restored the balance between alveolar epithelial Type I (AT1) and Type II (AT2) cells, indicating improved epithelial homeostasis. Toluidine Blue staining showed decreased mast-cell density after young plasma treatment (p\u2009&amp;lt;\u20090.05), reinforcing its anti-inflammatory effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Young plasma exerts regenerative and anti-inflammatory actions in the aged lung, highlighting it as a key target of systemic rejuvenation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glag007","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:38:45Z","timestamp":1768394325000},"source":"Crossref","is-referenced-by-count":0,"title":["Young plasma transfer enhances antioxidant defense and preserves structural integrity in aged lung tissue"],"prefix":"10.1093","volume":"81","author":[{"given":"\u00d6zlem","family":"D\u00fcvenci Birben","sequence":"first","affiliation":[{"name":"Chest Diseases Clinic, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital , Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6621-3071","authenticated-orcid":false,"given":"Hikmet Taner","family":"Teker","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ankara Medipol University , Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Van Yuzuncu Yil University , Van, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burcu","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Y\u00fcksek \u0130htisas University , Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-4664","authenticated-orcid":false,"given":"Enver Fehim","family":"Ko\u00e7p\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Techniques, Mu\u015f Alparslan University , Mus, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesila","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department Biology, Institute of Science, Mu\u015f Alparslan University , Mu\u015f, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevcan","family":"Kabayer","sequence":"additional","affiliation":[{"name":"Department Biology, Institute of Science, Mu\u015f Alparslan University , Mu\u015f, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan","family":"K\u00fclahl\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Forensic Toxicology, Ankara University , Ankara, T\u00fcrkiye"},{"name":"Integrated Technologies Research Center (B\u00dcTAM), Ankara University , Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3041-6010","authenticated-orcid":false,"given":"Taha","family":"Ceylani","sequence":"additional","affiliation":[{"name":"Department of Food Processing, Mu\u015f Alparslan University , Mu\u015f, T\u00fcrkiye"},{"name":"Department of Molecular Biology and Genetics, Mu\u015f Alparslan University , Mu\u015f, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"2026021523014975800_glag007-B1","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","article-title":"The mitochondrial basis of aging","volume":"61","author":"Sun","year":"2016","journal-title":"Mol Cell"},{"key":"2026021523014975800_glag007-B2","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.cell.2005.01.028","article-title":"DNA repair, genome stability, and aging","volume":"120","author":"Lombard","year":"2005","journal-title":"Cell"},{"key":"2026021523014975800_glag007-B3","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.cell.2016.07.050","article-title":"Epigenetic mechanisms of longevity and aging","volume":"166","author":"Sen","year":"2016","journal-title":"Cell"},{"key":"2026021523014975800_glag007-B4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. 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