{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:10:08Z","timestamp":1779336608678,"version":"3.51.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"McCall Hutchinson Foundation","award":["CB16\/10\/00477"],"award-info":[{"award-number":["CB16\/10\/00477"]}]},{"name":"McCall Hutchinson Foundation","award":["CB16\/10\/00456"],"award-info":[{"award-number":["CB16\/10\/00456"]}]},{"name":"McCall Hutchinson Foundation","award":["CB16\/10\/00464"],"award-info":[{"award-number":["CB16\/10\/00464"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteosarcopenia\u2014the coexistence of osteopenia\/osteoporosis and sarcopenia\u2014is associated with numerous adverse health outcomes, but its association with intrinsic capacity (IC) remains unknown. We aimed to explore the associations of osteosarcopenia with IC and all-cause mortality in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional analysis of IC and a prospective analysis of all-cause mortality in 1142 participants from the Toledo Study for Healthy Aging (75.1\u2009\u00b1\u20096.0\u2009years, 53.1% women). Participants were classified as having no musculoskeletal disorders, osteopenia\/osteoporosis, sarcopenia, or osteosarcopenia (DXA- and EWGSOP2-based criteria). IC was operationalized as a composite score integrating locomotion, cognition, psychological, vitality, and sensory domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Older adults with osteosarcopenia exhibited lower total IC (76.6\u2009\u00b1\u20091.1 points) than those without musculoskeletal disorders (83.7\u2009\u00b1\u20090.5 points; p\u2009&amp;lt;\u2009.001) or with osteopenia\/osteoporosis (81.3\u2009\u00b1\u20090.3 points; p\u2009&amp;lt;\u2009.001), with significant differences also found between the latter groups (p\u2009&amp;lt;\u2009.001). Specifically, osteosarcopenia was associated with poorer results in the locomotion, cognition, vitality, and sensory domains (all p\u2009&amp;lt;\u2009.01), but not in the psychological domain. Over a median 6.2-year follow-up, osteosarcopenia\u2014but not osteopenia\/osteoporosis\u2014was associated with a higher risk of mortality compared to those without musculoskeletal disorders [HR (95% CI)=1.96 (1.02-3.77); p\u2009=\u2009.045]. In joint analyses with IC status (high vs low, segregated by the median), this association was specifically observed among participants with osteosarcopenia and low IC [HR\u2009=\u20092.55 (1.31-4.96); p\u2009=\u2009.004].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Osteosarcopenia is associated with lower total IC and impairments across most IC domains. This finding is of clinical relevance, as the combination of this condition and low IC is associated with an increased mortality risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glag090","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:42:48Z","timestamp":1775043768000},"source":"Crossref","is-referenced-by-count":0,"title":["The interplay between osteosarcopenia and intrinsic capacity: insights and associations with all-cause mortality in the Toledo Study for Healthy Aging"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3434-623X","authenticated-orcid":false,"given":"Ivan","family":"Baltasar-Fernandez","sequence":"first","affiliation":[{"name":"GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha , Toledo,","place":["Spain"]},{"name":"Faculty of Health Sciences, University of Castilla-La Mancha , Talavera de la Reina,","place":["Spain"]},{"name":"Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM) , Toledo,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III , Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1730-3369","authenticated-orcid":false,"given":"Pedro L","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha , Toledo,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III , Madrid,","place":["Spain"]},{"name":"Department of Systems Biology, University of Alcal\u00e1 , Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1622-7109","authenticated-orcid":false,"given":"Irene","family":"Rodr\u00edguez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha , Toledo,","place":["Spain"]},{"name":"Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM) , Toledo,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III , Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Qui\u00f1onez-Bareiro","sequence":"additional","affiliation":[{"name":"Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM) , Toledo,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III , Madrid,","place":["Spain"]},{"name":"Geriatrics Department, Hospital Universitario de Toledo , Toledo,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4502-9275","authenticated-orcid":false,"given":"Luis M","family":"Alegre","sequence":"additional","affiliation":[{"name":"GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha , Toledo,","place":["Spain"]},{"name":"Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, Instituto de 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