{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:09:32Z","timestamp":1778573372358,"version":"3.51.4"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People with sickle cell disease (SCD) are at risk for accelerated biological aging and functional decline due to both age and SCD-related stressors. Frailty is characterized by decreased physiologic reserve and increased vulnerability to stressors that can lead to disability and death. The purpose of this study was to evaluate frailty phenotype in adults with SCD and identify factors associated with frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Frailty was defined by meeting \u22653 of the following criteria: slowness, weakness, weight loss, low physical activity, and exhaustion. Participants meeting 1-2 criteria were prefrail and \u201crobust\u201d if no criteria were present.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed frailty in 137 adults (age \u2265 18) with SCD in a single-center cross-sectional study (mean age 45; range 19-82). Three (2%) participants were frail, 47% prefrail, and 51% robust. Compared to robust, frail\/prefrail participants were more likely to have emergency department visits in the past year (66% vs 46%; p\u2009&amp;lt;\u2009.02), hypertension (42% vs 19%; p\u2009&amp;lt;\u2009.003), diabetes (16% vs 4%; p\u2009&amp;lt;\u2009.02), more SCD complications (2.8 vs 2.1; p\u2009&amp;lt;\u2009.02), and significantly worse socioeconomic status, cognitive function, depression, physical function, and disability in activities of daily living.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of prefrailty in this sample of young and predominantly middle-aged adults with SCD was similar to older adults in the general population, further supporting that accelerated aging occurs in this population and emphasizing the need for early identification and initiation of interventions to prevent and attenuate frailty in SCD. In future studies, we will evaluate SCD-specific cutpoints for frailty components that predict clinically meaningful outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glag091","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:40:45Z","timestamp":1775043645000},"source":"Crossref","is-referenced-by-count":0,"title":["Frailty phenotype in adults with sickle cell disease"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-7142","authenticated-orcid":false,"given":"Charity I","family":"Oyedeji","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology, Duke University School of Medicine , Durham, North Carolina,","place":["United States"]},{"name":"Claude D. Pepper Older Americans Independence Center, Duke University , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania E","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology, Duke University School of Medicine , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Faldowski","sequence":"additional","affiliation":[{"name":"Center for the Study of Aging and Human Development, Duke University School of Medicine , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teagan","family":"Callaway","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology, Duke University School of Medicine , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Poole","sequence":"additional","affiliation":[{"name":"School of Nursing, Duke University , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francyess","family":"Denis Oliva","sequence":"additional","affiliation":[{"name":"School of Medicine, Duke University , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Mathis","sequence":"additional","affiliation":[{"name":"Independent Consultant, Department of Medicine, Duke University, Durham, NC, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Brody School of Medicine, East Carolina University , Greenville, North Carolina,","place":["United States"]},{"name":"Nanbar Health LLC , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8417-4846","authenticated-orcid":false,"given":"Heather","family":"Whitson","sequence":"additional","affiliation":[{"name":"Claude D. Pepper Older Americans Independence Center, Duke University , Durham, North Carolina,","place":["United States"]},{"name":"Center for the Study of Aging and Human Development, Duke University School of Medicine , Durham, North Carolina,","place":["United States"]},{"name":"Geriatrics Research Education and Clinical Center, Durham VA Medical Center , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryce B","family":"Reeve","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Duke University School of Medicine , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4809-1725","authenticated-orcid":false,"given":"Carl","family":"Pieper","sequence":"additional","affiliation":[{"name":"Claude D. Pepper Older Americans Independence Center, Duke University , Durham, North Carolina,","place":["United States"]},{"name":"Center for the Study of Aging and Human Development, Duke University School of Medicine , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn J","family":"Telen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology, Duke University School of Medicine , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Ashley-Koch","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology, Duke University School of Medicine , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey J","family":"Cohen","sequence":"additional","affiliation":[{"name":"Claude D. Pepper Older Americans Independence Center, Duke University , Durham, North Carolina,","place":["United States"]},{"name":"Center for the Study of Aging and Human Development, Duke University School of Medicine , Durham, North Carolina,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-2011","authenticated-orcid":false,"given":"Katherine","family":"Hall","sequence":"additional","affiliation":[{"name":"Claude D. 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