{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:45:59Z","timestamp":1782927959138,"version":"3.54.5"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2017-01541"],"award-info":[{"award-number":["2017-01541"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2021-00905"],"award-info":[{"award-number":["2021-00905"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2024-02400"],"award-info":[{"award-number":["2024-02400"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Turning performance is an important and challenging motor activity, with potential relevance in several brain diseases. This study aimed to determine how Alzheimer\u2019s and vascular pathologies are associated with turning (360\u00b0 while standing and 180\u00b0 while walking), both as a single task and during dual-tasking in cognitively healthy older people.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cognitively healthy older people (n\u2009=\u2009297, mean age 77.7\u2009years, 61.6% women) were included. A 180\u00b0 turn was assessed using a wearable sensor; a 360\u00b0 turn was assessed both clinically and using a sensor. Dual-tasking included a simultaneous subtraction task. Alzheimer\u2019s pathologies (A\u03b2 and tau) were assessed using positron emission tomography (PET). Vascular pathology (white matter hyperintensities (WMH)) was assessed using magnetic resonance imaging (MRI). Logistic and linear regression analyses were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A\u03b2 and tau pathologies were significantly associated with being unstable while dual-tasking and turning 360\u00b0. When including both A\u03b2 and tau in the model, only tau remained significantly associated with being unstable (OR 22.42, 95% CI, 1.43, 349.88, p\u2009=\u2009.027). WMH were associated with impaired turning as a single task, that is, an increased turn duration (360\u00b0) and a decreased peak angular velocity (180\u00b0: B \u22121.27, 95% CI, \u22122.33, \u22120.21, p\u2009=\u2009.018).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that early Alzheimer\u2019s pathologies are associated with an instability while turning 360\u00b0 and dual-tasking, whereas WMH seem to be associated with impaired turning as a single task in cognitively healthy older people. Turning assessments seem promising for investigating motor aspects in very early stages of Alzheimer\u2019s disease and vascular brain disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glag114","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:25:48Z","timestamp":1777724748000},"source":"Crossref","is-referenced-by-count":0,"title":["Turning as a single and dual task\u2014associations with Alzheimer\u2019s and vascular pathologies in cognitively healthy older people"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-6721","authenticated-orcid":false,"given":"Maria H","family":"Nilsson","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine, Lund University , Lund,","place":["Sweden"]},{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6, Faculty of Medicine, Lund University , 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Lund, Lund University , Lund,","place":["Sweden"]},{"name":"Image and Function, Sk\u00e5ne University Hospital , Lund,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7147-0112","authenticated-orcid":false,"given":"Ruben","family":"Smith","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6, Faculty of Medicine, Lund University , Lund,","place":["Sweden"]},{"name":"Memory Clinic, Sk\u00e5ne University Hospital , Malm\u00f6,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9267-1930","authenticated-orcid":false,"given":"Sebastian","family":"Palmqvist","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6, Faculty of Medicine, Lund University , Lund,","place":["Sweden"]},{"name":"Memory Clinic, Sk\u00e5ne University 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