{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:45:54Z","timestamp":1782927954982,"version":"3.54.5"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia, the age-related loss of muscle mass and strength, poses a significant health and economic burden. This systematic review and meta-analysis evaluates circulating biomarkers (activin A, follistatin, growth differentiation factor (GDF-15), myostatin, growth hormone, insulin growth factor-1 (IGF-1), free and total testosterone) that may be associated with sarcopenia in community-dwelling older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA 2020 guidelines, we searched PubMed, Scopus, Web of Science, and Cochrane Library from inception to June 2025. Studies included adults without major comorbidities aged &amp;gt;60\u2009years with sarcopenia defined by established consensus. Standardized mean differences (SMDs) were calculated using a random-effects model. Heterogeneity was assessed via I2 and meta-regressions, while Egger\u2019s test was employed for publication bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 3488 records, 26 observational studies were included (n\u2009=\u20091345 adults with sarcopenia, 48.3% females, mean age 67.9-88.1\u2009years). Adults with sarcopenia showed elevated GDF-15 (k\u2009=\u20095, SMD: 0.26, 95% confidence interval (95% CI), 0.03 to 0.50, I2 = 64%, p\u2009=\u2009.03) and reduced IGF-1 (k\u2009=\u200911, SMD: \u22120.40, 95% CI, \u22120.54 to \u22120.27, I2 = 36%, p\u2009&amp;lt;\u2009.01) compared to controls without sarcopenia. No significant differences were found between groups for the other circulating biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated circulating IGF-1 and, to a lesser extent, GDF-15, may be promising biomarkers for sarcopenia. Larger, longitudinal studies are needed to address heterogeneity and causality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glag140","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:44:30Z","timestamp":1779882270000},"source":"Crossref","is-referenced-by-count":0,"title":["Circulating biomarkers\u00a0in older adults with and without sarcopenia: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-9388","authenticated-orcid":false,"given":"Konstantinos","family":"Prokopidis","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Ageing and Science, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen S","family":"Deane","sequence":"additional","affiliation":[{"name":"Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital , Southampton,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoubayda","family":"Baoubbou","sequence":"additional","affiliation":[{"name":"Public Health Aging Research and Epidemiology (PHARE) Group, Research Unit in Clinical Pharmacology and Toxicology (URPC), NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur , Namur,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Beaudart","sequence":"additional","affiliation":[{"name":"Public Health Aging Research and Epidemiology (PHARE) Group, Research Unit in Clinical Pharmacology and Toxicology (URPC), NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur , 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