{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:09:01Z","timestamp":1780373341768,"version":"3.54.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sarcopenia, the age-related loss of muscle mass and function, poses a significant health burden in aging societies. Although mitochondrial dysfunction is a recognized driver, the upstream molecular regulators remain poorly defined. Here, we identify the mitochondrial translocator protein (TSPO) as a novel negative regulator of myogenesis that is consistently upregulated in aged and sarcopenic muscle. Using gain- and loss-of-function approaches in C2C12 myoblasts, we show that TSPO overexpression disrupts mitochondrial homeostasis, impairs proliferation and differentiation, while TSPO knockdown produces opposite effects\u2014establishing TSPO as a critical modulator of myogenic capacity. Mechanistically, TSPO suppresses the Wnt\/\u03b2-catenin pathway, and this effect is partially mediated by ROS accumulation. Importantly, in vivo AAV9-mediated TSPO knockdown in aged mice not only restores mitochondrial integrity but also significantly improves muscle mass, strength, and exercise performance. Collectively, our findings uncover a TSPO\u2013Wnt\/\u03b2-catenin axis that links mitochondrial dysfunction to impaired muscle regeneration in aging. Targeting TSPO may offer a dual-action therapeutic strategy to combat sarcopenia by simultaneously enhancing mitochondrial bioenergetics and reactivating pro-myogenic signaling.<\/jats:p>","DOI":"10.1093\/gerona\/glag145","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:47:42Z","timestamp":1780055262000},"source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial Dysfunction in Myoblasts: A TSPO-Dependent Mechanism of Sarcopenia"],"prefix":"10.1093","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Hubei University of Arts and Science Xiangyang Central Hospital, , Xiangyang, 441021, Hubei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhao","family":"Dai","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Clinical Center of Orthopedics and Sports Medicine, , Fuzhou, 350001,","place":["China"]},{"name":"Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhai","family":"Yang","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Deng","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Song","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Su","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine Department of Traditional Chinese Medicine, , Fuzhou, 350122,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongsheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Yu","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Clinical Center of Orthopedics and Sports Medicine, , Fuzhou, 350001,","place":["China"]},{"name":"Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Clinical Center of Orthopedics and Sports Medicine, , Fuzhou, 350001,","place":["China"]},{"name":"Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Clinical Center of Orthopedics and Sports Medicine, , Fuzhou, 350001,","place":["China"]},{"name":"Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenqi","family":"Luo","sequence":"additional","affiliation":[{"name":"Fujian Medical University Shengli Clinical Medical College, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Department of Orthopedics, Fujian Provincial Hospital, , Fuzhou, 350001,","place":["China"]},{"name":"Fuzhou University Affiliated Provincial Hospital Clinical Center of Orthopedics and Sports Medicine, , Fuzhou, 350001,","place":["China"]},{"name":"Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases , Fuzhou, 350001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,2]]},"container-title":["The Journals of Gerontology, Series A: Biological Sciences and Medical 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