{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T17:29:59Z","timestamp":1786469399818,"version":"build-2736575974"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004325","name":"Signe and Ane Gyllenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004325","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Samfundet Folkh\u00e4lsan; Finska L\u00e4kares\u00e4llskapet"},{"DOI":"10.13039\/501100004037","name":"Juho Vainio Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010116","name":"Medicinska Underst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010116","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Finnish Foundation for Cardiovascular Research"},{"name":"Finnish Foundation for Diabetes Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Physical activity may counteract aging-associated disruptions in the metabolome. We investigated how leisure-time physical activity (LTPA) associates with the metabolome in late midlife and with 15-year metabolomic trajectories. The study included 1816 Helsinki Birth Cohort Study participants at baseline (mean age 61.6\u2009years), with 985, 996, and 740 participants at the 5-, 10-, and 15-year follow-ups, respectively. LTPA was assessed at baseline and after 15\u2009years using a validated questionnaire and expressed as METhours\/week. Nuclear magnetic resonance-based metabolomics data from fasting blood samples were used to analyze 161 biomarkers at baseline and at each follow-up. Weighted Gene Co-Expression Network Analysis was performed on the metabolomics data to identify 11 metabolomic biomarker modules. Baseline associations were analyzed using restricted cubic splines and longitudinal associations with linear mixed-effects models. Analyses were sex-stratified, covariate-adjusted, and corrected for multiple testing. At baseline, LTPA was nonlinearly associated with albumin in women and with 9 biomarkers in men in the crude, but not fully adjusted, model. Over the follow-up, baseline LTPA was associated with the age-related trajectory of triglyceride-enriched high-density lipoprotein (HDL) module in men (age \u00d7 LTPA interaction p\u2009=\u2009.041). In the high LTPA group, the trajectory declined significantly compared to the low (p\u2009=\u2009.004) and moderate LTPA groups (p\u2009=\u2009.045). No associations were found in women. To conclude, in men, higher LTPA in late midlife predicted a favorable 15-year trajectory of triglyceride-enriched HDL. Our findings indicate that an active lifestyle is associated with more favorable metabolomic trajectories related to cardiometabolic health across late midlife and old age.<\/jats:p>","DOI":"10.1093\/gerona\/glag159","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:51:29Z","timestamp":1781092289000},"source":"Crossref","is-referenced-by-count":0,"title":["Leisure-time physical activity and metabolomic trajectories over the transition from late midlife to old age"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1707-4503","authenticated-orcid":false,"given":"Katri","family":"Ruutu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Helsinki , Helsinki,","place":["Finland"]},{"name":"Folkh\u00e4lsan Research Center , 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