{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:00:13Z","timestamp":1791381613909,"version":"4.3.3"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Age-related increases in chronic systemic inflammation are strong predictors of morbidity and mortality in high income countries, but evidence is lacking from lower- and middle-income settings where infectious diseases are more prevalent and rates of overweight and obesity are relatively low. Here we evaluate two complementary measures of chronic inflammation\u2014plasma C-reactive protein (CRP) and a DNA methylation\u2013based surrogate (DNAm-CRP)\u2014measured at baseline as predictors of physical capacity, cognitive function, and cardiometabolic disease seven years later among women in the Philippines (N\u2009=\u2009953; 43-75 years at follow-up). Levels of CRP and DNAm-CRP were not strongly associated with age. Both measures predicted subsequent declines in physical and functional capacity, increased incidence of diabetes and hypertension, and poorer cognitive performance, after adjustment for baseline status and other covariates. DNAm-CRP performed comparably to CRP, and was robust to variation in white blood cell composition and acute infectious symptoms at the time of sampling. These findings demonstrate that chronic inflammation is associated with multiple dimensions of aging in a lower-middle income setting, and highlights the utility of inflammatory biomarkers as scalable tools for global aging research.<\/jats:p>","DOI":"10.1093\/gerona\/glag246","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:53:16Z","timestamp":1791373996000},"source":"Crossref","is-referenced-by-count":0,"title":["Chronic inflammation and multiple dimensions of aging among women in the Philippines"],"prefix":"10.1093","author":[{"given":"Thomas W","family":"McDade","sequence":"first","affiliation":[{"name":"Northwestern University Department of Anthropology, , Evanston, IL 60208"},{"name":"Northwestern University Institute for Policy Research, , Evanston, IL 60208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Carrera","sequence":"additional","affiliation":[{"name":"Northwestern University Department of Anthropology, , Evanston, IL 60208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calen P","family":"Ryan","sequence":"additional","affiliation":[{"name":"Columbia University Mailman School of Public Health Robert N. Butler Columbia Aging Center, Department of Epidemiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah","family":"Watson","sequence":"additional","affiliation":[{"name":"Northwestern University Department of Anthropology, , Evanston, IL 60208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S","family":"Adair","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill Department of Nutrition, Gillings School of Global Public Health, Carolina Population Center, CB #8120,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanette R","family":"Lee","sequence":"additional","affiliation":[{"name":"University of San Carlos Office of Population Studies Foundation, , Talamban, Cebu City","place":["Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia B","family":"Carba","sequence":"additional","affiliation":[{"name":"University of San Carlos Office of Population Studies Foundation, , Talamban, Cebu City","place":["Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie L","family":"MacIsaac","sequence":"additional","affiliation":[{"name":"University of British Columbia Edwin S.H. Leong Centre for Healthy Aging, Faculty of Medicine, , Vancouver,","place":["Canada"]},{"name":"University of British Columbia Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, , Vancouver, British Columbia,","place":["Canada"]},{"name":"British Columbia Children\u2019s Hospital Research Institute , Vancouver, British Columbia,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Dever","sequence":"additional","affiliation":[{"name":"University of British Columbia Edwin S.H. Leong Centre for Healthy Aging, Faculty of Medicine, , Vancouver,","place":["Canada"]},{"name":"University of British Columbia Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, , Vancouver, British Columbia,","place":["Canada"]},{"name":"British Columbia Children\u2019s Hospital Research Institute , Vancouver, British Columbia,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Kobor","sequence":"additional","affiliation":[{"name":"University of British Columbia Edwin S.H. Leong Centre for Healthy Aging, Faculty of Medicine, , Vancouver,","place":["Canada"]},{"name":"University of British Columbia Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, , Vancouver, British Columbia,","place":["Canada"]},{"name":"British Columbia Children\u2019s Hospital Research Institute , Vancouver, British Columbia,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W","family":"Kuzawa","sequence":"additional","affiliation":[{"name":"Harvard University Department of Human Evolutionary Biology, , Cambridge MA 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,7]]},"container-title":["The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/advance-article-pdf\/doi\/10.1093\/gerona\/glag246\/71665534\/glag246.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/advance-article-pdf\/doi\/10.1093\/gerona\/glag246\/71665534\/glag246.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:43:03Z","timestamp":1791380583000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/advance-article\/doi\/10.1093\/gerona\/glag246\/8875712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/gerona\/glag246","relation":{},"ISSN":["1079-5006","1758-535X"],"issn-type":[{"value":"1079-5006","type":"print"},{"value":"1758-535X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"article-number":"glag246"}}