{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:06Z","timestamp":1792785906939,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG027810"],"award-info":[{"award-number":["U01 AG027810"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042124"],"award-info":[{"award-number":["U01 AG042124"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042139"],"award-info":[{"award-number":["U01 AG042139"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042140"],"award-info":[{"award-number":["U01 AG042140"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042143"],"award-info":[{"award-number":["U01 AG042143"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042145"],"award-info":[{"award-number":["U01 AG042145"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042168"],"award-info":[{"award-number":["U01 AG042168"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AR066160"],"award-info":[{"award-number":["U01 AR066160"]}]},{"name":"NIH Roadmap for Medical Research","award":["UL1 TR000128"],"award-info":[{"award-number":["UL1 TR000128"]}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,16]]},"DOI":"10.1093\/gerona\/gly129","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T20:07:45Z","timestamp":1528747665000},"page":"844-852","source":"Crossref","is-referenced-by-count":206,"title":["Strong Relation Between Muscle Mass Determined by D3-creatine Dilution, Physical Performance, and Incidence of Falls and Mobility Limitations in a Prospective Cohort of Older Men"],"prefix":"10.1093","volume":"74","author":[{"given":"Peggy M","family":"Cawthon","sequence":"first","affiliation":[{"name":"Research Institute, California Pacific Medical Center, San Francisco"},{"name":"Department of Epidemiology and Biostatistics, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S","family":"Orwoll","sequence":"additional","affiliation":[{"name":"Department of Medicine, Oregon Health and Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E","family":"Peters","sequence":"additional","affiliation":[{"name":"Research Institute, California Pacific Medical Center, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine E","family":"Ensrud","sequence":"additional","affiliation":[{"name":"Center for Chronic Disease Outcomes Research, Minneapolis VA Health Care System, Minnesota"},{"name":"Division of Epidemiology and Community Health, University of Minnesota, Minneapolis"},{"name":"Department of Medicine, University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A","family":"Cauley","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M","family":"Kado","sequence":"additional","affiliation":[{"name":"Departments of Family Medicine & Public Health and Internal Medicine, University of California, San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia L","family":"Stefanick","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford Prevention Research Center, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Shikany","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa S","family":"Strotmeyer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy W","family":"Glynn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Caserotti","sequence":"additional","affiliation":[{"name":"Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahalakshmi","family":"Shankaran","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Toxicology, University of California, Berkeley"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hellerstein","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Toxicology, University of California, Berkeley"},{"name":"Department of Medicine, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R","family":"Cummings","sequence":"additional","affiliation":[{"name":"Research Institute, California Pacific Medical Center, San Francisco"},{"name":"Department of Epidemiology and Biostatistics, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Toxicology, University of California, Berkeley"},{"name":"Department of Medicine, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Osteoporotic Fractures in Men (MrOS) Study Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"2019051611305145900_CIT0001","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/oxfordjournals.aje.a009520","article-title":"Epidemiology of sarcopenia among the elderly in New Mexico","volume":"147","author":"Baumgartner","year":"1998","journal-title":"Am J Epidemiol"},{"key":"2019051611305145900_CIT0002","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1111\/jgs.13788","article-title":"Evaluation of the usefulness of consensus definitions of sarcopenia in older men: results from the observational osteoporotic fractures in men cohort study","volume":"63","author":"Cawthon","year":"2015","journal-title":"J Am Geriatr Soc"},{"key":"2019051611305145900_CIT0003","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1111\/j.1532-5415.2009.02366.x","article-title":"Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults","volume":"57","author":"Cawthon","year":"2009","journal-title":"J Am Geriatr Soc"},{"key":"2019051611305145900_CIT0004","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/epirev\/mxs006","article-title":"Adiposity, muscle mass, and muscle strength in relation to functional decline in older persons","volume":"35","author":"Schaap","year":"2013","journal-title":"Epidemiol Rev"},{"key":"2019051611305145900_CIT0005","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1532-5415.2005.00540.x","article-title":"Influence of sarcopenia on the development of physical disability: the Cardiovascular Health Study","volume":"54","author":"Janssen","year":"2006","journal-title":"J Am Geriatr Soc"},{"key":"2019051611305145900_CIT0006","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1532-5415.2002.50216.x","article-title":"Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability","volume":"50","author":"Janssen","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"2019051611305145900_CIT0007","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/BF03324682","article-title":"High baseline values of fat mass, independently of appendicular skeletal mass, predict 2-year onset of disability in elderly subjects at the high end of the functional spectrum","volume":"19","author":"Zoico","year":"2007","journal-title":"Aging Clin Exp Res"},{"key":"2019051611305145900_CIT0008","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/aje\/kwj217","article-title":"The relations of body composition and adiposity measures to ill health and physical disability in elderly men","volume":"164","author":"Ramsay","year":"2006","journal-title":"Am J Epidemiol"},{"key":"2019051611305145900_CIT0009","doi-asserted-by":"crossref","first-page":"M214","DOI":"10.1093\/gerona\/53A.3.M214","article-title":"Body fat and skeletal muscle mass in relation to physical disability in very old men and women of the Framingham Heart Study","volume":"53","author":"Visser","year":"1998","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2019051611305145900_CIT0010","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/ajcn\/68.3.584","article-title":"High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study","volume":"68","author":"Visser","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"2019051611305145900_CIT0011","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/gerona\/60.3.324","article-title":"Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons","volume":"60","author":"Visser","year":"2005","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2019051611305145900_CIT0012","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1152\/japplphysiol.00246.2003","article-title":"Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia","volume":"95","author":"Lauretani","year":"2003","journal-title":"J Appl Physiol (1985)"},{"key":"2019051611305145900_CIT0013","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jamda.2011.01.003","article-title":"Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia","volume":"12","author":"Fielding","year":"2011","journal-title":"J Am Med Dir Assoc"},{"key":"2019051611305145900_CIT0014","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"key":"2019051611305145900_CIT0015","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/gerona\/glu010","article-title":"The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates","volume":"69","author":"Studenski","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2019051611305145900_CIT0016","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1001\/jama.288.15.1889","article-title":"Clinical use of bone densitometry: scientific review","volume":"288","author":"Cummings","year":"2002","journal-title":"JAMA"},{"key":"2019051611305145900_CIT0017","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1046\/j.1532-5415.2003.51534.x","article-title":"Sarcopenia: alternative definitions and associations with lower extremity function","volume":"51","author":"Newman","year":"2003","journal-title":"J Am Geriatr Soc"},{"key":"2019051611305145900_CIT0018","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/gerona\/glu023","article-title":"Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness","volume":"69","author":"Cawthon","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2019051611305145900_CIT0019","doi-asserted-by":"crossref","DOI":"10.1007\/s13539-013-0110-1","article-title":"Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D-creatine dilution method","author":"Stimpson","year":"2013","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2019051611305145900_CIT0020","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1152\/japplphysiol.00122.2012","article-title":"Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-D3) dilution in rats","volume":"112","author":"Stimpson","year":"2012","journal-title":"J Appl Physiol (1985)"},{"key":"2019051611305145900_CIT0021","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1152\/japplphysiol.00045.2014","article-title":"Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans","volume":"116","author":"Clark","year":"2014","journal-title":"J Appl Physiol (1985)"},{"key":"2019051611305145900_CIT0022","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.cct.2005.05.005","article-title":"Overview of recruitment for the osteoporotic fractures in men study (MrOS)","volume":"26","author":"Blank","year":"2005","journal-title":"Contemp Clin Trials"},{"key":"2019051611305145900_CIT0023","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cct.2005.05.006","article-title":"Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study\u2013a large observational study of the determinants of fracture in older men","volume":"26","author":"Orwoll","year":"2005","journal-title":"Contemp Clin Trials"},{"key":"2019051611305145900_CIT0024","first-page":"540","article-title":"Dilution of oral D(3) - Creatine to measure creatine pool size and estimate skeletal muscle mass: development of a correction algorithm","volume-title":"J Cachexia Sarcopenia Muscle","author":"Shankaran","year":"2018"},{"key":"2019051611305145900_CIT0025","volume-title":"Creatine and Creatinine, Monographs on Biochemistry","author":"Hunter","year":"1928"},{"key":"2019051611305145900_CIT0026","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2165\/00007256-199418040-00005","article-title":"Creatine in humans with special reference to creatine supplementation","volume":"18","author":"Balsom","year":"1994","journal-title":"Sports Med"},{"key":"2019051611305145900_CIT0027","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1212\/WNL.18.1_Part_1.32","article-title":"Creatine metabolism in skeletal muscle. II. Creatine kinetics in man","volume":"18","author":"Fitch","year":"1968","journal-title":"Neurology"},{"key":"2019051611305145900_CIT0028","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1152\/physrev.2000.80.3.1107","article-title":"Creatine and creatinine metabolism","volume":"80","author":"Wyss","year":"2000","journal-title":"Physiol Rev"},{"key":"2019051611305145900_CIT0029","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0021-9258(18)73484-4","article-title":"Studies in protein metabolism","volume":"131","author":"Bloch","year":"1939","journal-title":"J Biol Chem"},{"key":"2019051611305145900_CIT0030","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/ajcn\/37.3.478","article-title":"Measurement of muscle mass in humans: validity of the 24-hour urinary creatinine method","volume":"37","author":"Heymsfield","year":"1983","journal-title":"Am J Clin Nutr"},{"key":"2019051611305145900_CIT0031","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1600-0838.2007.00732.x","article-title":"Explosive heavy-resistance training in old and very old adults: changes in rapid muscle force, strength and power","volume":"18","author":"Caserotti","year":"2008","journal-title":"Scand J Med Sci Sports"},{"key":"2019051611305145900_CIT0032","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s004210170006","article-title":"Contraction-specific differences in maximal muscle power during stretch-shortening cycle movements in elderly males and females","volume":"84","author":"Caserotti","year":"2001","journal-title":"Eur J Appl Physiol"},{"key":"2019051611305145900_CIT0033","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1359\/jbmr.080227","article-title":"Physical performance and risk of hip fractures in older men","volume":"23","author":"Cawthon","year":"2008","journal-title":"J Bone Miner Res"},{"key":"2019051611305145900_CIT0034","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1056\/NEJM199503023320902","article-title":"Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability","volume":"332","author":"Guralnik","year":"1995","journal-title":"N Engl J Med"},{"key":"2019051611305145900_CIT0035","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1001\/jama.295.17.2018","article-title":"Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability","volume":"295","author":"Newman","year":"2006","journal-title":"JAMA"},{"key":"2019051611305145900_CIT0036","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1532-5415.2010.03245.x","article-title":"Mortality risk in older men associated with changes in weight, lean mass, and fat mass","volume":"59","author":"Lee","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"2019051611305145900_CIT0037","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1046\/j.1532-5415.2003.51105.x","article-title":"Strength and muscle quality in a well-functioning cohort of older adults: the Health, Aging and Body Composition Study","volume":"51","author":"Newman","year":"2003","journal-title":"J Am Geriatr Soc"},{"key":"2019051611305145900_CIT0038","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1532-5415.2006.00701.x","article-title":"Meaningful change and responsiveness in common physical performance measures in older adults","volume":"54","author":"Perera","year":"2006","journal-title":"J Am Geriatr Soc"},{"key":"2019051611305145900_CIT0039","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/gerona\/61.1.72","article-title":"Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort","volume":"61","author":"Newman","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2019051611305145900_CIT0040","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/01.mco.0000165010.31826.3d","article-title":"Dual-energy X-ray absorptiometry and body composition","volume":"8","author":"Plank","year":"2005","journal-title":"Curr Opin Clin Nutr Metab Care"}],"container-title":["The Journals of Gerontology: Series A"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/74\/6\/844\/28658107\/gly129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T09:58:29Z","timestamp":1661421509000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article\/74\/6\/844\/5035193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,12]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,12]]},"published-print":{"date-parts":[[2019,5,16]]}},"URL":"https:\/\/doi.org\/10.1093\/gerona\/gly129","relation":{},"ISSN":["1079-5006","1758-535X"],"issn-type":[{"value":"1079-5006","type":"print"},{"value":"1758-535X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,6]]},"published":{"date-parts":[[2018,6,12]]}}}