{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:56:45Z","timestamp":1793314605866,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health Research or the Department of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Orthostatic hypotension (OH) is associated with increased risk of falls, cognitive impairment and death, as well as a reduced quality of life. Although it is presumed to be common in older people, estimates of its prevalence vary widely. This study aims to address this by pooling the results of epidemiological studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>MEDLINE, EMBASE, PubMed, Web of Science, and ProQuest were searched. Studies were included if participants were more than 60 years, were set within the community or within long-term care and diagnosis was based on a postural drop in systolic blood pressure (BP) \u226520 mmHg or diastolic BP \u226510 mmHg. Data were extracted independently by two reviewers. Random and quality effects models were used for pooled analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 23,090 identified records, 20 studies were included for community-dwelling older people (n = 24,967) and six were included for older people in long-term settings (n = 2,694). There was substantial variation in methods used to identify OH with differing supine rest duration, frequency and timing of standing BP, measurement device, use of standing and tilt-tables and interpretation of the diagnostic drop in BP. The pooled prevalence of OH in community-dwelling older people was 22.2% (95% CI = 17, 28) and 23.9% (95% CI = 18.2, 30.1) in long-term settings. There was significant heterogeneity in both pooled results (I2 &amp;gt; 90%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>OH is very common, affecting one in five community-dwelling older people and almost one in four older people in long-term care. There is great variability in methods used to identify OH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/gly188","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T20:42:04Z","timestamp":1538167324000},"page":"117-122","source":"Crossref","is-referenced-by-count":160,"title":["The Prevalence of Orthostatic Hypotension: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"75","author":[{"given":"Nor I\u2019zzati","family":"Saedon","sequence":"first","affiliation":[{"name":"Ageing and Age-Associated Disorders Research Group, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maw","family":"Pin Tan","sequence":"additional","affiliation":[{"name":"Ageing and Age-Associated Disorders Research Group, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6491-3701","authenticated-orcid":false,"given":"James","family":"Frith","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK"},{"name":"Falls and Syncope Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"2019121307580420600_CIT0001","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman","year":"2011","journal-title":"Clin Auton Res"},{"key":"2019121307580420600_CIT0002","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4065\/70.7.617","article-title":"Prospective evaluation of clinical characteristics of orthostatic hypotension","volume":"70","author":"Low","year":"1995","journal-title":"Mayo Clin Proc"},{"key":"2019121307580420600_CIT0003","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1097\/HJH.0000000000000235","article-title":"Association between orthostatic hypotension and cardiovascular risk, cerebrovascular risk, cognitive decline and falls as well as overall mortality: a systematic review and meta-analysis","volume":"32","author":"Angelousi","year":"2014","journal-title":"J Hypertens"},{"key":"2019121307580420600_CIT0004","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/eurheartj\/ehv093","article-title":"Cardiovascular morbidity and mortality related to orthostatic hypotension: a meta-analysis of prospective observational studies","volume":"36","author":"Ricci","year":"2015","journal-title":"Eur Heart J"},{"key":"2019121307580420600_CIT0005","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/ageing\/aft112","article-title":"The prevalence and pathological correlates of orthostatic hypotension and its subtypes when measured using beat-to-beat technology in a sample of older adults living in the community","volume":"42","author":"Cooke","year":"2013","journal-title":"Age Ageing"},{"key":"2019121307580420600_CIT0006","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1001\/jama.1987.03400110093033","article-title":"Low prevalence of postural hypotension among community-dwelling elderly","volume":"258","author":"Mader","year":"1987","journal-title":"JAMA"},{"key":"2019121307580420600_CIT0007","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jclinepi.2011.11.014","article-title":"Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement","volume":"65","author":"Hoy","year":"2012","journal-title":"J Clin Epidemiol"},{"key":"2019121307580420600_CIT0008","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jclinepi.2014.03.003","article-title":"In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias","volume":"67","author":"Hunter","year":"2014","journal-title":"J Clin Epidemiol"},{"key":"2019121307580420600_CIT0009","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/01.HYP.33.5.1123","article-title":"Descriptive epidemiology of blood pressure response to change in body position. 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