{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:30:00Z","timestamp":1790703000530,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AG050499"],"award-info":[{"award-number":["U01AG050499"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute on Aging Cooperative Agreement","award":["U01AG050499"],"award-info":[{"award-number":["U01AG050499"]}]},{"DOI":"10.13039\/100007698","name":"University of Florida","doi-asserted-by":"publisher","award":["P30AG028740"],"award-info":[{"award-number":["P30AG028740"]}],"id":[{"id":"10.13039\/100007698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007154","name":"Wake Forest University","doi-asserted-by":"publisher","award":["P30AG021332"],"award-info":[{"award-number":["P30AG021332"]}],"id":[{"id":"10.13039\/100007154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008090","name":"Tufts University","doi-asserted-by":"publisher","award":["P30AG031679"],"award-info":[{"award-number":["P30AG031679"]}],"id":[{"id":"10.13039\/100008090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","award":["P30AG024827"],"award-info":[{"award-number":["P30AG024827"]}],"id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Boston Rehabilitation Outcomes Center","award":["R24HD065688-01A1"],"award-info":[{"award-number":["R24HD065688-01A1"]}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["58-1950-0-014"],"award-info":[{"award-number":["58-1950-0-014"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low-grade chronic inflammation, characterized by elevations in plasma Interleukin-6 (IL-6), is an independent risk factor of impaired mobility in older persons. Angiotensin receptor blockers and omega-3 polyunsaturated fatty acids (\u03c9-3) may reduce IL-6 and may potentially improve physical function. To assess the main effects of the angiotensin receptor blocker losartan and \u03c9-3 as fish oil on IL-6 and 400 m walking speed, we conducted the ENRGISE Pilot multicenter randomized clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ENRGISE Pilot enrolled participants between April 2016 and June 2017, who participated for 12 months. Participants were aged \u226570 years with mobility impairment, had IL-6 between 2.5 and 30 pg\/mL, and were able to walk 400 m at baseline. Participants were randomized in three strata 2 \u00d7 2 factorial to: (i) losartan 50\u2013100 mg\/d or placebo (n = 43), (ii) fish oil 1,400\u20132,800 mg\/d or placebo (n = 180), and (iii) with both (n = 66).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred eighty-nine participants were randomized (mean age 78.3 years, 47.4% women, 17.0% black). There was no effect of losartan (difference of means = \u22120.065 \u00b1 0.116 [SE], 95% confidence interval [CI]: \u22120.293\u20130.163, p = .58) or fish oil (\u22120.020 \u00b1 0.077, 95% CI: \u22120.171\u20130.132, p = .80) on the log of IL-6. Similarly, there was no effect of losartan (\u22120.025 \u00b1 0.026, 95% CI: \u22120.076\u20130.026, p = .34) or fish oil (0.010 \u00b1 0.017, 95% CI: \u22120.025\u20130.044, p = .58) on walking speed (m\/s).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results do not support the use of these interventions to prevent mobility loss in older adults at risk of disability with low-grade chronic inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>Clinicaltrials.gov NCT02676466.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/gly277","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T05:33:59Z","timestamp":1544592839000},"page":"1612-1619","source":"Crossref","is-referenced-by-count":46,"title":["Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial"],"prefix":"10.1093","volume":"74","author":[{"given":"Marco","family":"Pahor","sequence":"first","affiliation":[{"name":"Department of Aging and Geriatric Research, University of Florida, Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D","family":"Anton","sequence":"first","affiliation":[{"name":"Department of Aging and Geriatric Research, University of Florida, Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P","family":"Beavers","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A","family":"Cauley","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 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