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We hypothesize that higher PVAT volume at midlife is prospectively associated with slower gait speed later in life, independent of overall adiposity and other risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants from the Study of Women\u2019s Health Across the Nation (SWAN) cardiovascular fat ancillary study were included. PVAT volume around the descending aorta was quantified using existing computed tomography scans at midlife, while gait speed was measured after an average of 10.4 \u00b1 0.7 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred and seventy-six women (aged 51.3 \u00b1 2.8 years at PVAT assessment) were included. Mean gait speed was 0.96 \u00b1 0.21 m\/s. Adjusting for study site, race, education level, menopausal status, and length of descending aorta at PVAT assessment, and age, body mass index, difficulty paying for basics, overall health and smoking status at gait speed assessment, a higher midlife PVAT volume was associated with a slower gait speed later in life (p = .03). With further adjustment for presence of any comorbid conditions by the time of gait speed assessment, the association persisted; every 1SD increase in log-PVAT was associated with 3.3% slower gait speed (95% confidence interval: 0.3\u20136.3%; p = .03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Greater PVAT in midlife women may contribute to poorer physical function in older age supporting a potential role of midlife PVAT in multiple domains of healthy aging. Additional research is needed to fully elucidate the physiologic changes associated with PVAT that may underlie the observed associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glz095","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T20:37:28Z","timestamp":1555101448000},"page":"1959-1964","source":"Crossref","is-referenced-by-count":7,"title":["Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study"],"prefix":"10.1093","volume":"74","author":[{"given":"Samar R","family":"El Khoudary","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xirun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Nasr","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Shields","sequence":"additional","affiliation":[{"name":"Enterprise Analytics, Highmark Health, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Barinas-Mitchell","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imke","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A","family":"Everson-Rose","sequence":"additional","affiliation":[{"name":"Department of Medicine and Program in Health Disparities Research, University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Medicine and Program in Health Disparities Research, University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Matthews","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"2019111315184211900_CIT0001","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1515\/hmbci-2015-0010","article-title":"Perivascular adipose tissue, inflammation and insulin resistance: link to vascular dysfunction and cardiovascular disease","volume":"22","author":"Lastra","year":"2015","journal-title":"Horm Mol Biol Clin Investig"},{"key":"2019111315184211900_CIT0002","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s11906-016-0692-z","article-title":"A clinical perspective: contribution of dysfunctional perivascular adipose tissue (PVAT) to cardiovascular risk","volume":"18","author":"Lian","year":"2016","journal-title":"Curr Hypertens Rep"},{"key":"2019111315184211900_CIT0003","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1161\/ATVBAHA.114.303029","article-title":"Perivascular adipose tissue in vascular function and disease: a review of current research and animal models","volume":"34","author":"Brown","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2019111315184211900_CIT0004","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2147\/VHRM.S33760","article-title":"The influence of perivascular adipose tissue on vascular homeostasis","volume":"9","author":"Szasz","year":"2013","journal-title":"Vasc Health Risk Manag"},{"key":"2019111315184211900_CIT0005","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1161\/hc4301.097195","article-title":"Perivascular inflammation after balloon angioplasty of porcine coronary arteries","volume":"104","author":"Okamoto","year":"2001","journal-title":"Circulation"},{"key":"2019111315184211900_CIT0006","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.atherosclerosis.2012.08.031","article-title":"Coronary perivascular adipose tissue characteristics are related to atherosclerotic plaque size and composition. 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