{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:22:04Z","timestamp":1775247724645,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K01AR063167"],"award-info":[{"award-number":["K01AR063167"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R21AR062284"],"award-info":[{"award-number":["R21AR062284"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000980","name":"Arthritis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01AG62101"],"award-info":[{"award-number":["N01AG62101"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01AG62103"],"award-info":[{"award-number":["N01AG62103"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01AG62106"],"award-info":[{"award-number":["N01AG62106"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG028050"],"award-info":[{"award-number":["R01AG028050"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01NR012459"],"award-info":[{"award-number":["R01NR012459"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wake Forest Older Americans Independence Center","award":["P30AG021332"],"award-info":[{"award-number":["P30AG021332"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Vitamin K has been implicated in chronic diseases associated with increased risk for mobility disability, such as osteoarthritis and cardiovascular disease. However, the association between vitamin K status and mobility disability is unknown. Therefore, we examined the association between vitamin K status and incident mobility disability in the Health, Aging, and Body Composition Study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Plasma phylloquinone (vitamin K1) was categorized as &amp;lt;0.5, 0.5\u2013&amp;lt;1.0 and \u22651.0 nmol\/L (n = 1,323, 48% male). Plasma ucMGP, which increases when vitamin K status is low, was measured in 716 participants and categorized into tertiles. Mobility limitation and disability, defined as two consecutive semiannual reports of having any or a lot of difficulty walking a one-fourth mile or climbing 10 steps without resting, were assessed over a median 6\u201310 years of follow-up. Multivariate Cox proportional hazard models were used to evaluate the association between vitamin K status and incident mobility limitation and disability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Participants with plasma phylloquinone less than 0.5 nmol\/L were more likely to develop mobility limitation and disability compared to those with at least 1.0 nmol\/L (adjusted HR (95% CI) mobility limitation: 1.27 (1.05\u20131.53); disability: 1.34 (1.01\u20131.76)). After further adjustment for knee pain, the associations were partially attenuated (HR (95% CI) mobility limitation: 1.20 (0.99\u20131.45); disability: 1.26 (0.96\u20131.67)). Plasma ucMGP was not associated with incident mobility limitation, but was nonlinearly associated with incident mobility disability (HR (95% CI), compared to tertile 1: tertile 2 = 1.64 (1.19\u20132.27), tertile 3 = 1.17 (0.83\u20131.66), fully adjusted).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results suggest vitamin K may be involved in the disablement process in older age. Future studies are needed to confirm our findings and clarify the underlying mechanism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glz108","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T13:44:03Z","timestamp":1557150243000},"page":"792-797","source":"Crossref","is-referenced-by-count":16,"title":["Vitamin K Status and Mobility Limitation and Disability in Older Adults: The Health, Aging, and Body Composition Study"],"prefix":"10.1093","volume":"75","author":[{"given":"M Kyla","family":"Shea","sequence":"first","affiliation":[{"name":"USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-6781","authenticated-orcid":false,"given":"Stephen B","family":"Kritchevsky","sequence":"first","affiliation":[{"name":"Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F","family":"Loeser","sequence":"first","affiliation":[{"name":"Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L","family":"Booth","sequence":"first","affiliation":[{"name":"USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"2020070107540325700_CIT0001","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s13668-016-0162-x","article-title":"The role of vitamin K in chronic aging diseases: inflammation, cardiovascular disease, and osteoarthritis","volume":"5","author":"Harshman","year":"2016","journal-title":"Curr Nutr 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