{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:21:23Z","timestamp":1778923283900,"version":"3.51.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RC1 HL099395 and U19 HL91179"],"award-info":[{"award-number":["RC1 HL099395 and U19 HL91179"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>To examine the individual and combined associations of noncardiac-related conditions and mobility limitation with morbidity and mortality in adults with heart failure (HF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective cohort study in a large, diverse group of adults with HF from five U.S. integrated healthcare delivery systems. We characterized patients with respect to the presence of noncardiac conditions (&amp;lt;3 vs \u22653) and\/or mobility impairment (defined by the use\/nonuse of a wheelchair, cane, or walker), categorizing them into four subgroups. Outcomes included all-cause death and hospitalizations for HF or any cause.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 114,553 adults diagnosed with HF (mean age: 73 years old, 46% women), compared with &amp;lt;3 noncardiac conditions\/no mobility limitation, adjusted hazard ratios (HR) for all-cause death among those with &amp;lt;3 noncardiac conditions\/mobility limitation, \u22653 noncardiac conditions\/no mobility limitation, \u22653 noncardiac conditions\/mobility limitation (vs) were 1.40 (95% CI, 1.31\u20131.51), 1.72 (95% CI, 1.69\u20131.75), and 1.93 (95% CI, 1.85\u20132.01), respectively. We did not observe an increased risk of any-cause or HF-related hospitalization related to the presence of mobility limitation among those with a greater burden of noncardiac multimorbidity. Consistent findings regarding mortality were observed within groups defined according to age, gender, and HF type (preserved, reduced, mid-range ejection fraction), with the most prominent impact of mobility limitation in those &amp;lt;65 years of age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There is an additive association of mobility limitation, beyond the burden of noncardiac multimorbidity, on mortality for patients with HF, and especially prominent in younger patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glz285","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T05:47:16Z","timestamp":1575870436000},"page":"1981-1988","source":"Crossref","is-referenced-by-count":7,"title":["Noncardiac-Related Morbidity, Mobility Limitation, and Outcomes in Older Adults With Heart Failure"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8557-2029","authenticated-orcid":false,"given":"Mayra","family":"Tisminetzky","sequence":"first","affiliation":[{"name":"Meyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts"},{"name":"Division of Geriatric Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester"},{"name":"Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry H","family":"Gurwitz","sequence":"additional","affiliation":[{"name":"Meyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts"},{"name":"Division of Geriatric Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester"},{"name":"Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongjie","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Fouayzi","sequence":"additional","affiliation":[{"name":"Meyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue Hee","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Meyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts"},{"name":"Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S","family":"Go","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland"},{"name":"Department of Epidemiology and University of California, San Francisco"},{"name":"Department of Biostatistics and University of California, San Francisco"},{"name":"Department of Medicine, University of California, San Francisco"},{"name":"Department of Medicine, Stanford University, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"2020092513350659200_CIT0001","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/bmj.327.7414.513","article-title":"Polypharmacy and comorbidity in heart failure","volume":"327","author":"Masoudi","year":"2003","journal-title":"BMJ."},{"key":"2020092513350659200_CIT0002","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0735-1097(03)00947-1","article-title":"Noncardiac comorbidity increases preventable hospitalizations and mortality among Medicare beneficiaries with chronic heart 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