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The present research analyzes multiple large-scale studies with a consistent analytic approach to evaluate the association between personality and change in episodic memory over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Across nine public longitudinal data sets, 120,640 participants provided 471,821 memory assessments over up to 26 years (age range 18\u2013108). FFM traits were tested as predictors of the average level (intercept) and change over time (slope) of episodic memory. Results from the individual samples were meta-analyzed to summarize the associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Consistent with expectations for the intercept, higher neuroticism was associated with worse memory performance, whereas higher openness and conscientiousness were associated with better performance; extraversion and agreeableness were also associated with better performance. Higher neuroticism and lower conscientiousness were related to declines in memory only in samples with more than two assessments of memory. The other three traits were unrelated to memory slope. The pattern was similar when participants with dementia were excluded from the analysis, and the association with the slope was not moderated by age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>FFM traits have a robust association with average memory performance. Higher neuroticism and lower conscientiousness were associated with declines in memory performance only among samples with more than two memory assessments. The heterogeneity across studies suggests that multiple memory assessments are needed to reliably detect change over time, which may be one reason for past inconsistencies across studies.<\/jats:p><\/jats:sec>","DOI":"10.1093\/geronb\/gbac154","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T20:14:54Z","timestamp":1664482494000},"page":"421-433","source":"Crossref","is-referenced-by-count":32,"title":["Five-Factor Model Personality Traits and the Trajectory of Episodic Memory: Individual-Participant Meta-Analysis of 471,821 Memory Assessments from 120,640 Participants"],"prefix":"10.1093","volume":"78","author":[{"given":"Angelina R","family":"Sutin","sequence":"first","affiliation":[{"name":"Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine , Tallahassee, Florida , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine , Tallahassee, Florida , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7370-8443","authenticated-orcid":false,"given":"Martina","family":"Luchetti","sequence":"additional","affiliation":[{"name":"Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine , Tallahassee, Florida , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damaris","family":"Aschwanden","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Florida State University College of Medicine , Tallahassee, Florida , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Stephan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Florida State University College of Medicine , Tallahassee, Florida , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-8885","authenticated-orcid":false,"given":"Antonio","family":"Terracciano","sequence":"additional","affiliation":[{"name":"Euromov, University of Montpellier , Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"2023030412404714500_","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1177\/0733464817698816","article-title":"Health-related behavior mediates the association between personality and memory performance in older adults","volume":"28","author":"Allen","year":"2019","journal-title":"Journal of Applied Gerontology"},{"issue":"3","key":"2023030412404714500_","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1037\/hea0000429","article-title":"Personality and sedentary behavior: A systematic review and meta-analysis","volume":"36","author":"Allen","year":"2017","journal-title":"Health Psychology"},{"key":"2023030412404714500_","doi-asserted-by":"crossref","first-page":"101269","DOI":"10.1016\/j.arr.2021.101269","article-title":"Is personality associated with dementia risk? 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