{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T04:34:38Z","timestamp":1775363678154,"version":"3.50.1"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["NIA U01AG009740"],"award-info":[{"award-number":["NIA U01AG009740"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AG000037"],"award-info":[{"award-number":["T32AG000037"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG017265"],"award-info":[{"award-number":["P30AG017265"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Social stress has been shown to affect immune functioning. Past research has found that chronic social stress and latent viral infections accelerate immune aging, leading to chronic disease morbidity and mortality. Chronic stress may also reactivate latent viral infections, like cytomegalovirus (CMV), accelerating the aging of the immune system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Utilizing panel survey data from 8,995 U.S. adults aged 56 or older from the Health and Retirement Study, this study investigates whether chronic stress interacts with CMV positivity to drive aging of the immune system, multimorbidity, and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Results of moderated mediation analysis indicate that the effect of CMV positivity on morbidity and mortality as mediated by immune aging indicators is amplified by chronic stress.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>These findings suggest that immune aging is a biological pathway underlying the stress process and help explain past findings in the literature on stress and health.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/geronb\/gbad087","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T20:18:08Z","timestamp":1686255488000},"page":"1707-1716","source":"Crossref","is-referenced-by-count":10,"title":["Chronic Stress and Latent Virus Reactivation: Effects on Immune Aging, Chronic Disease Morbidity, and Mortality"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-1332","authenticated-orcid":false,"given":"Eric T","family":"Klopack","sequence":"first","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California , Los Angeles, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"2024021312011585700_CIT0001","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.psyneuen.2016.01.024","article-title":"PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit","volume":"67","author":"Aiello","year":"2016","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"2024021312011585700_CIT0002","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/PSY.0000000000000320","article-title":"Income and markers of immunological cellular aging","volume":"78","author":"Aiello","year":"2016","journal-title":"Psychosomatic Medicine"},{"key":"2024021312011585700_CIT0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.02247","article-title":"Immunosenescence and its hallmarks: How to oppose aging strategically? 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