{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:03:35Z","timestamp":1740153815162,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Cancer Center Research and Development","award":["23-A-31","26-A-2","29-A-4","2020-J-4"],"award-info":[{"award-number":["23-A-31","26-A-2","29-A-4","2020-J-4"]}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS Kakenhi","award":["16H05246","21H03194","23H03171"],"award-info":[{"award-number":["16H05246","21H03194","23H03171"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Life enjoyment, linked to the ability to engage pleasurably with one\u2019s environment, may be related to the risk of developing dementia. This prospective cohort study examined the association between level of life enjoyment and disabling dementia incidence among Japanese community residents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The participants were Japanese, aged 45\u201374 years old at 5-years follow-up, in the Japan Public Health Center\u2013based Study (N = 38,660). Psychological conditions and other confounding variables were identified through self-administered questionnaires. Incident disabling dementia registered based on the Japan\u2019s Long-Term Care Insurance system from 2006 to 2016. Hazard ratios [95% confidence intervals] were assessed using Cox proportional hazards models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Over a median follow-up period of 9.4 years, a total of 4,642 cases of disabling dementia developed. Level of life enjoyment was inversely associated with the risk of disabling dementia: the multivariable hazard ratios were 0.75 [0.67\u20130.84] (p &amp;lt; .001) and 0.68 [0.59\u20130.78] (p &amp;lt; .001) with medium and high life enjoyment, respectively, compared to low life enjoyment. Furthermore, the association between greater life enjoyment and low risk for disabling dementia was strongest in the subgroup with low\u2013medium mental stress. In the high mental stress group, this association was evident for poststroke disabling dementia, but not for disabling dementia without a history of stroke.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>A higher level of life enjoyment was associated with a lower risk of disabling dementia, particularly in the low\u2013medium mental stress group. This finding suggests the importance of having life enjoyment by managing mental stress for reducing risk of disabling dementia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/geronb\/gbad129","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:49:28Z","timestamp":1695023368000},"page":"2001-2008","source":"Crossref","is-referenced-by-count":0,"title":["Perceived Level of Life Enjoyment and Risk of Developing Disabling Dementia: The Japan Public Health Center\u2013Based Study"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-2453","authenticated-orcid":false,"given":"Tomokazu","family":"Tajima","sequence":"first","affiliation":[{"name":"Department of Public Health, Juntendo University Graduate School of Medicine , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Public Health, Juntendo 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