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However, there is a dearth of literature examining these relationships in Black adults. We investigated whether depression or WMH volume are associated with a higher likelihood of dementia diagnosis in a sample of late middle-aged to older Black adults, and whether dementia prevalence is highest in individuals with both depression and higher WMH volume.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Secondary data analysis involved 443 Black participants aged 55+ with brain imaging within 1 year of baseline visit in the National Alzheimer\u2019s Coordinating Center Uniform Data Set. Chi-square analyses and logistic regression models controlling for demographic variables examined whether active depression in the past 2 years, WMH volume, or their combination were associated with higher odds of all-cause dementia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Depression and higher WMH volume were associated with a higher prevalence of dementia. These associations remained after controlling for demographic factors, as well as vascular disease burden. Dementia risk was highest in the depression\/high WMH volume group compared to the depression-only group, high WMH volume-only group, and the no depression\/low WMH volume group. Post hoc analyses comparing the Black sample to a demographically matched non-Hispanic White sample showed associations of depression and the combination of depression and higher WMH burden with dementia were greater in Black compared to non-Hispanic White individuals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Results suggest late-life depression and WMH have independent and joint relationships with dementia and that Black individuals may be particularly at risk due to these factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/geronb\/gbae009","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T07:25:25Z","timestamp":1708413925000},"source":"Crossref","is-referenced-by-count":5,"title":["Depression, Vascular Burden, and Dementia Prevalence in Late Middle-Aged and Older Black Adults"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-2887","authenticated-orcid":false,"given":"Shellie-Anne","family":"Levy","sequence":"first","affiliation":[{"name":"Department of Clinical and Health Psychology, The Center for Cognitive Aging and Memory, University of Florida , Gainesville, Florida ,","place":["USA"]},{"name":"The Center for Cognitive Aging and Memory, University of Florida , Gainesville, Florida ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria B","family":"Misiura","sequence":"additional","affiliation":[{"name":"Department of Psychology, Georgia State University , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy G","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology, The Center for Cognitive Aging and Memory, University of Florida , Gainesville, Florida ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamare V","family":"Adrien","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology, The Center for Cognitive Aging and Memory, University of Florida , Gainesville, Florida ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinat","family":"Taiwo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Psychology and Neuropsychology, TIRR Memorial Hermann , Houston, Texas ,","place":["USA"]},{"name":"H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology, The Center for Cognitive Aging and Memory, University of Florida , Gainesville, Florida ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-3320","authenticated-orcid":false,"given":"Vonetta M","family":"Dotson","sequence":"additional","affiliation":[{"name":"Department of Psychology, Georgia State University , Atlanta, Georgia ,","place":["USA"]},{"name":"Gerontology Institute, Georgia State University , Atlanta, Georgia 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