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Multidomain lifestyle interventions are a promising strategy for the prevention of cognitive decline. The aim of this study was to investigate whether the presence of SMCs affects the efficacy of a 2-year multidomain lifestyle intervention on cognition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study is part of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) project. Participants (a subsample of 568 individuals, baseline age 60-77 years) were randomized (1:1) to receive a 2-year multidomain lifestyle intervention group including dietary advice, exercise, cognitive training, and vascular risk management, or regular health advice control group. Cognitive performance was assessed at baseline and at 1- and 2-year visits, using a neuropsychological test battery, including tests assessing memory, executive functions, and processing speed. Participants rated the frequency of SMCs using the Prospective and Retrospective Memory Questionnaire.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Having more retrospective SMCs was linked to a less favorable cognitive trajectory over 2 years. The difference between the intervention and control groups in annual change in tested memory performance was 0.077 (95% CI, 0.008\u20130.146) among those reporting more retrospective SMCs and \u22120.011 (\u22120.074 to 0.053) among those with less SMCs; interaction effect p\u2005=\u2005.019. No other interactions between SMCs and intervention allocation were observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>A lifestyle intervention may be beneficial for older adults with and without SMCs. Persons having more retrospective SMCs may benefit more from the intervention regarding memory functioning.<\/jats:p>\n                  <jats:p>Clinical Trials Registration Number: NCT01041989<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/geronb\/gbae179","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T08:17:34Z","timestamp":1729844254000},"source":"Crossref","is-referenced-by-count":2,"title":["Subjective Memory Complaints and the Effect of a Multidomain Lifestyle Intervention on Cognition: The FINGER Trial"],"prefix":"10.1093","volume":"80","author":[{"given":"Laura","family":"Vaskivuo","sequence":"first","affiliation":[{"name":"Department of Public Health, Finnish Institute for Health and Welfare , Helsinki ,","place":["Finland"]},{"name":"Department of Psychology and Logopedics,\u00a0Faculty of Medicine, University of Helsinki , Helsinki 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