{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:11:27Z","timestamp":1791447087850,"version":"4.3.3"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":186,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding of China","award":["2022-GSP-TS-8"],"award-info":[{"award-number":["2022-GSP-TS-8"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["T2015-ZX038"],"award-info":[{"award-number":["T2015-ZX038"]}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202306210379"],"award-info":[{"award-number":["202306210379"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>The relationship between physical frailty, age-related conditions, and the incidence of degenerative valvular heart disease (VHD) remains unclear. This study aimed to investigate the potential association between physical frailty and the development of degenerative VHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods<\/jats:title>\n                    <jats:p>Participants from the UK Biobank who were initially free of VHD and heart failure were categorized into 3 groups based on the frailty phenotype: non-frailty, pre-frailty, and frailty. The frailty phenotype was determined by evaluating the following 5 components: weight loss, exhaustion, reduced physical activity, slow gait speed, and low grip strength. The incidence of degenerative VHD, including mitral valve regurgitation (MR), aortic valve regurgitation (AR), and aortic valve stenosis (AS), was assessed using hospital admission or death registries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 331\u00a0642 participants, 11\u00a0885 (3.6%) exhibited frailty and 143\u00a0379 (43.2%) were categorized as pre-frailty. During a median follow-up of 13.8 years, there were 3\u00a0684 MR, 1\u00a0205 AR, and 3\u00a0166 AS events. Compared to non-frailty participants, those with pre-frailty and frailty showed significantly increased risks for MR (hazard ratio [HR], HRpre-frailty:1.19, 95% confidence interval [CI]: 1.11\u20131.28; HRfrailty: 1.50, 95% CI: 1.30\u20131.74), AR (HRpre-frailty:1.19, 95% CI: 1.05\u20131.34; HRfrailty: 1.58, 95% CI: 1.22\u20132.04), and AS (HRpre-frailty:1.19, 95% CI: 1.11\u20131.29; HRfrailty: 1.74, 95% CI: 1.51\u20132.00). Among the 5 components, slow gait speed showed the strongest association with the risk of various types of VHD (HRMR: 1.50, 95% CI: 1.34\u20131.65; HRAR: 1.50, 95% CI: 1.24\u20131.80; HRAS: 1.46, 95% CI: 1.32\u20131.62), followed by exhaustion, low grip strength, and weight loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Implications<\/jats:title>\n                    <jats:p>Pre-frailty and frailty were associated with a higher risk of all 3 types of degenerative VHD. Early detection and intervention for pre-frailty and frailty in middle-aged and older individuals may assist in preventing or delaying the onset of degenerative VHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/geroni\/igae062","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:53:38Z","timestamp":1720054418000},"source":"Crossref","is-referenced-by-count":8,"title":["Physical Frailty and the Risk of Degenerative Valvular Heart Disease"],"prefix":"10.1093","volume":"8","author":[{"given":"Xinli","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular 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