{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:58:42Z","timestamp":1787626722070,"version":"build-2736575974"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Sichuan Key Laboratory of Nursing Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Objectives<\/jats:title>\n                  <jats:p>The complex interplay between diet, gut microbiota, and metabolic health has gained increasing recognition as a key factor in the development of obesity and related conditions, such as sarcopenia. This study examines the relationship between the dietary index for gut microbiota (DI-GM) and sarcopenia, while exploring the potential mediating role of the body roundness index (BRI) in this association. By integrating these factors, our findings aim to shed light on the diet-gut microbiota-sarcopenia interaction and its implications for personalized dietary interventions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Research Design and Methods<\/jats:title>\n                  <jats:p>Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. Multivariable weighted regression analyses were conducted to assess the association between DI-GM and sarcopenia. Restricted cubic spline analyses were used to evaluate potential non-linear relationships. Additionally, mediation analysis was performed to determine whether the BRI mediated the relationship between DI-GM and sarcopenia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 10,190 participants were included in the study, of whom 7.57% were diagnosed with sarcopenia. In the weighted linear regression analysis, each one-point increase in DI-GM was associated with a 12% reduction in the prevalence of sarcopenia (OR\u2009=\u20090.88, 95% CI: 0.82, 0.95). Specifically, a higher beneficial gut microbiota score was significantly associated with a lower prevalence of sarcopenia (OR\u2009=\u20090.82, 95% CI: 0.75, 0.89). Mediation analysis revealed that BRI accounted for 23% of the total effect of DI-GM on sarcopenia. Among the beneficial components, those with a significant mediation effect contributed approximately 9% of the total effect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion and Implications<\/jats:title>\n                  <jats:p>The DI-GM was found to be negatively associated with the prevalence of sarcopenia, with BRI playing a crucial mediating role. These findings highlight the importance of the diet-gut microbiota-sarcopenia interaction and underscore the potential for incorporating dietary and microbiota-targeted interventions in personalized therapeutic strategies for sarcopenia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/geroni\/igaf065","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T17:18:09Z","timestamp":1751131089000},"source":"Crossref","is-referenced-by-count":5,"title":["Association of dietary index for gut microbiota and sarcopenia: the mediation effect of body roundness index"],"prefix":"10.1093","volume":"9","author":[{"given":"Shan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nursing, The First Affiliated Hospital of Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nursing, The First Affiliated Hospital of Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoning","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Nursing, The First Affiliated Hospital of Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nursing, The First Affiliated Hospital of Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nursing, The First Affiliated Hospital of Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Nursing, The First Affiliated Hospital of Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Public Health, Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nursing, The First Affiliated Hospital of Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"2025082819572254800_igaf065-B1","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment","volume":"21","author":"Chen","year":"2020","journal-title":"J Am Med Dir Assoc"},{"key":"2025082819572254800_igaf065-B2","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Cruz-Jentoft","year":"2019","journal-title":"Lancet"},{"key":"2025082819572254800_igaf065-B3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/ageing\/afl024","article-title":"Is grip strength associated with health-related quality of life? 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