{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:59:44Z","timestamp":1790312384633,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Physical exercise is widely recognized as an effective non-pharmacological intervention that improves not only functional capacity, but also cognition and quality of life in older adults. However, the molecular pathways through which it influences aging-related processes remain incompletely understood. This systematic review and meta-analysis aimed to synthesize current evidence on the effects of structured physical exercise intervention on molecular biomarkers associated with inflammation and oxidative stress in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods<\/jats:title>\n                    <jats:p>Randomized controlled trials which included participants \u226565 years old were identified through searches of PubMed, Scopus, Web of Science, CINAHL, and the Cochrane Library.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 50 reports (4,379 participants) were included in the qualitative synthesis, and 38 of them in the different meta-analyses performed. Exercise interventions ranged from 8 weeks to 12 months and included aerobic, resistance, and multicomponent training. Pooled analyses indicated modest but significant reductions in C-Reactive Protein (CRP) and high-sensitivity CRP, as well as increases in IL-10. Effects on other pro-inflammatory cytokines, including IL-6 and TNF-\u03b1, were inconsistent across studies. Evidence from a limited number of trials (n\u2009=\u20096) also suggested improvements in redox balance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Implications<\/jats:title>\n                    <jats:p>Overall, structured physical exercise demonstrates a moderate immunomodulatory and antioxidant effect in older adults, although bias was moderate to high. PROSPERO registry: CRD420251006248.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/geront\/gnag228","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:24:11Z","timestamp":1790310251000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of supervised physical exercise on inflammatory and oxidative stress biomarkers in older adults: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9232-7497","authenticated-orcid":false,"given":"Chenhui","family":"Chenhuichen","sequence":"first","affiliation":[{"name":"Navarre Public University (UPNA) , Pamplona, Navarra,","place":["Spain"]},{"name":"University Hospital of Navarra (HUN) , Department of Geriatrics, Pamplona, Navarra,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9691-5998","authenticated-orcid":false,"given":"Yasmin","family":"Ezzatvar","sequence":"additional","affiliation":[{"name":"University of Val\u00e8ncia Lifestyle factors with impact on Ageing and overall Health (LAH) Research Group. Department of Nursing. , Valencia,","place":["Spain"]},{"name":"Universidad de Los Lagos Vicerrector\u00eda de Investigaci\u00f3n y Postgrado, , Osorno,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-5269","authenticated-orcid":false,"given":"Fabiola","family":"Zambom-Ferraresi","sequence":"additional","affiliation":[{"name":"Navarra Institute for Health Research (IdiSNA) Miguel Servet\u2019s Foundation \u2013 Navarrabiomed, , Pamplona, Navarra,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3894-355X","authenticated-orcid":false,"given":"Carly","family":"Welch","sequence":"additional","affiliation":[{"name":"King's College London Department of Twin Research and Genetic Epidemiology, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, , London,","place":["UK"]},{"name":"NHS Foundation Trust Department of Ageing and Health, , Guy's and St ThomasWestminster Bridge, London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Gorospe","sequence":"additional","affiliation":[{"name":"National Institute on Aging, NIH Laboratory of Genetics and Genomics, , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-8385","authenticated-orcid":false,"given":"Marta","family":"Montes Resano","sequence":"additional","affiliation":[{"name":"University of Navarra RNA and senescence Group, Center for Applied Medical Research,"},{"name":"Cancer Center University of Navarra Clinic (CCUN) , Pamplona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3229-6614","authenticated-orcid":false,"given":"Marta","family":"Guti\u00e9rrez-Valencia","sequence":"additional","affiliation":[{"name":"Navarra Institute for Health Research (IdiSNA) Miguel Servet\u2019s Foundation \u2013 Navarrabiomed, , Pamplona, Navarra,","place":["Spain"]},{"name":"Navarre Health Service Innovation and Organization Unit, , Pamplona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1641-3881","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"Lasarte Sagastibelza","sequence":"additional","affiliation":[{"name":"Cancer Center University of Navarra Clinic (CCUN) , Pamplona,","place":["Spain"]},{"name":"University of Navarra Immunology and Immunotherapy Program, Center for Applied Medical Research,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6320-9600","authenticated-orcid":false,"given":"Thomas","family":"Jackson","sequence":"additional","affiliation":[{"name":"University of Birmingham Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, , Birmingham,","place":["UK"]},{"name":"Queen Elizabeth Hospital Birmingham Department of Healthcare for Older People, , Birmingham,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9576-9960","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Mart\u00ednez-Velilla","sequence":"additional","affiliation":[{"name":"Navarre Public University (UPNA) , Pamplona, Navarra,","place":["Spain"]},{"name":"University Hospital of Navarra (HUN) , Department of Geriatrics, Pamplona, Navarra,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,24]]},"container-title":["The Gerontologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/gerontologist\/advance-article-pdf\/doi\/10.1093\/geront\/gnag228\/71384345\/gnag228.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gerontologist\/advance-article-pdf\/doi\/10.1093\/geront\/gnag228\/71384345\/gnag228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:24:11Z","timestamp":1790310251000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gerontologist\/advance-article\/doi\/10.1093\/geront\/gnag228\/8834112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/geront\/gnag228","relation":{},"ISSN":["0016-9013","1758-5341"],"issn-type":[{"value":"0016-9013","type":"print"},{"value":"1758-5341","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"article-number":"gnag228"}}