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Similar to other neurodegenerative disorders, such as Alzheimer and Parkinson disease, ALS pathology is presumed to propagate over time, originating from the motor cortex and spreading to other cortical regions. Exploring early disease stages is crucial to understand the causative molecular changes underlying the pathology. For this, we sampled human postmortem prefrontal cortex (PFC) tissue from Brodmann area 6, an area that exhibits only moderate pathology at the time of death, and performed a multiomic analysis of 51 patients with sporadic ALS and 50 control subjects. To compare sporadic disease to genetic ALS, we additionally analyzed PFC tissue from 4 transgenic ALS mouse models (C9orf72-, SOD1-, TDP-43-, and FUS-ALS) using the same methods. This multiomic data resource includes transcriptome, small RNAome, and proteome data from female and male samples, aimed at elucidating early and sex-specific ALS mechanisms, biomarkers, and drug targets.<\/jats:p>","DOI":"10.1093\/gigascience\/giae100","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T14:58:41Z","timestamp":1734533921000},"source":"Crossref","is-referenced-by-count":4,"title":["A dataset profiling the multiomic landscape of the prefrontal cortex in amyotrophic lateral sclerosis"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-5824","authenticated-orcid":false,"given":"Fabian","family":"Hausmann","sequence":"first","affiliation":[{"name":"Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neuroscience (ZMNH), University Medical Center Hamburg-Eppendorf , Hamburg 20251 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