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We compared associations of a genetic score (GS-CAD) for 224 SNPs for acute CAD with chronic IHD (n = 9,000), heart failure (n = 1,229), stroke (n = 10,208), CVD risk factors (n = 70,364), and plasma proteomics (n = 3,904) in CKB.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The strength of associations of 224 CAD SNPs discovered in Europeans was moderately correlated with those for acute CAD in Chinese (r = 0.53), but significant associations were only replicated (P &lt; 0.05) for 25 SNPs. The strength of associations with acute CAD for a 1 SD higher GS for acute CAD in Chinese was 3-fold greater than for chronic IHD or heart failure (1.22 [1.18\u20131.26] vs. 1.07 [1.05\u20131.10] vs. 1.06 [1.00\u20131.12], respectively) and 7-fold greater than for stroke (1.03; 1.01\u20131.05). Higher levels of GS-CAD were strongly associated with low-density lipoprotein cholesterol, moderately with systolic blood pressure and weakly with body mass index, but not with proteomics.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The findings demonstrate a moderate concordance of genetic determinants for acute CAD between Europeans and Chinese that were specific for CAD and only weakly associated with chronic IHD, heart failure, or ischaemic stroke.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/gigascience\/giag084","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:42:16Z","timestamp":1786448536000},"source":"Crossref","is-referenced-by-count":0,"title":["Concordance of genetic determinants of acute coronary artery disease between European and Chinese 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