{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:10:01Z","timestamp":1787753401146,"version":"build-2784847793"},"reference-count":148,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI140736"],"award-info":[{"award-number":["R01AI140736"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Genomics Shared Resource and Flow and Image Cytometry Shared Resource"},{"name":"National Cancer Institute Cancer Center","award":["5P30 CA016056"],"award-info":[{"award-number":["5P30 CA016056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interactions between the neonate host and its gut microbiome are central to the development of a healthy immune system. However, the mechanisms by which animals alter early colonization of microbiota for their benefit remain unclear. Here, we investigated the role of early-life expression of the \u03b12,6-sialyltransferase ST6GAL1 in microbiome phylogeny and mucosal immunity. Fecal, upper respiratory, and oral microbiomes of pups expressing or lacking St6gal1 were analyzed by 16S rRNA sequencing. At weaning, the fecal microbiome of St6gal1-KO mice had reduced Clostridiodes, Coprobacillus, and Adlercreutzia, but increased Helicobacter and Bilophila. Pooled fecal microbiomes from syngeneic donors were transferred to antibiotic-treated wild-type mice, before analysis of recipient mucosal immune responses by flow cytometry, RT-qPCR, microscopy, and ELISA. Transfer of St6gal1-KO microbiome induced a mucosal Th17 response, with expression of T-bet and IL-17, and IL-22-dependent gut lengthening. Early life intestinal sialylation was characterized by RT-qPCR, immunoblot, microscopy, and sialyltransferase enzyme assays in genetic mouse models at rest or with glucocorticoid receptor modulators. St6gal1 expression was greatest in the duodenum, where it was mediated by the P1 promoter and efficiently inhibited by dexamethasone. Our data show that the inability to produce \u03b12,6-sialyl ligands contributes to microbiome-dependent Th17 inflammation, highlighting a pathway by which the intestinal glycosylation regulates mucosal immunity.<\/jats:p>","DOI":"10.1093\/glycob\/cwac005","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T15:12:05Z","timestamp":1644419525000},"page":"414-428","source":"Crossref","is-referenced-by-count":14,"title":["Bacterial colonization and TH17 immunity are shaped by intestinal sialylation in neonatal mice"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2282-5244","authenticated-orcid":false,"given":"Eric E","family":"Irons","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0966-6488","authenticated-orcid":false,"given":"Eduardo","family":"Cortes Gomez","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie L","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5128-2664","authenticated-orcid":false,"given":"Joseph T Y","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,12]]},"reference":[{"key":"2022042117414594200_ref1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.immuni.2012.04.011","article-title":"Commensal bacteria calibrate the activation threshold of innate antiviral immunity","volume":"37","author":"Abt","year":"2012","journal-title":"Immunity"},{"key":"2022042117414594200_ref2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-2148-9-118","article-title":"Insights into the evolution of sialic acid catabolism among bacteria","volume":"9","author":"Almagro-Moreno","year":"2009","journal-title":"BMC Evol Biol"},{"key":"2022042117414594200_ref3","first-page":"731","article-title":"Lymphocyte emigration from high endothelial venules in rat lymph 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