{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:50:33Z","timestamp":1762674633166,"version":"3.41.2"},"reference-count":27,"publisher":"Oxford University Press (OUP)","funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJND2204"],"award-info":[{"award-number":["JPMJND2204"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Center for Biotechnology Information"},{"DOI":"10.13039\/100000092","name":"National Library of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The GlyCosmos Glycoscience Portal (https:\/\/glycosmos.org) and PubChem (https:\/\/pubchem.ncbi.nlm.nih.gov\/) are major portals for glycoscience and chemistry, respectively. GlyCosmos is a portal for glycan-related repositories, including GlyTouCan, GlycoPOST, and UniCarb-DR, as well as for glycan-related data resources that have been integrated from a variety of \u2018omics databases. Glycogenes, glycoproteins, lectins, pathways, and disease information related to glycans are accessible from GlyCosmos. PubChem, on the other hand, is a chemistry-based portal at the National Center for Biotechnology Information. PubChem provides information not only on chemicals, but also genes, proteins, pathways, as well as patents, bioassays, and more, from hundreds of data resources from around the world. In this work, these 2 portals have made substantial efforts to integrate their complementary data to allow users to cross between these 2 domains. In addition to glycan structures, key information, such as glycan-related genes, relevant diseases, glycoproteins, and pathways, was integrated and cross-linked with one another. The interfaces were designed to enable users to easily find, access, download, and reuse data of interest across these resources. Use cases are described illustrating and highlighting the type of content that can be investigated. In total, these integrations provide life science researchers improved awareness and enhanced access to glycan-related information.<\/jats:p>","DOI":"10.1093\/glycob\/cwad028","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T14:54:07Z","timestamp":1683039247000},"source":"Crossref","is-referenced-by-count":4,"title":["Bridging glycoinformatics and cheminformatics: integration efforts between GlyCosmos and PubChem"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4486-3356","authenticated-orcid":false,"given":"Tiejun","family":"Cheng","sequence":"first","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bethesda, MD 20894 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamiko","family":"Ono","sequence":"additional","affiliation":[{"name":"Glycan and Life Systems Integration Center, Soka University , 1-236 Tangi-machi, Hachioji, Tokyo 192-8577 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Shiota","sequence":"additional","affiliation":[{"name":"Glycan and Life Systems Integration Center, Soka University , 1-236 Tangi-machi, Hachioji, Tokyo 192-8577 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9504-189X","authenticated-orcid":false,"given":"Issaku","family":"Yamada","sequence":"additional","affiliation":[{"name":"Laboratory of Glycoinformatics, The Noguchi Institute , 1-9-7 Kaga, Itabashi, Tokyo 173-0003 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-8015","authenticated-orcid":false,"given":"Kiyoko F","family":"Aoki-Kinoshita","sequence":"additional","affiliation":[{"name":"Glycan and Life Systems Integration Center, Soka University , 1-236 Tangi-machi, Hachioji, Tokyo 192-8577 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5959-6190","authenticated-orcid":false,"given":"Evan E","family":"Bolton","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bethesda, MD 20894 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"issue":"1","key":"2023053116494955900_ref1","doi-asserted-by":"crossref","DOI":"10.1186\/2041-1480-6-3","article-title":"Implementation of linked data in the life sciences at BioHackathon 2011","volume":"6","author":"Aoki-Kinoshita","year":"2015","journal-title":"J Biomed Semantics"},{"issue":"2","key":"2023053116494955900_ref2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/glycob\/cwz078","article-title":"The GlySpace alliance: toward a collaborative global glycoinformatics community","volume":"30","author":"Aoki-Kinoshita","year":"2020","journal-title":"Glycobiology"},{"issue":"D1","key":"2023053116494955900_ref3","doi-asserted-by":"crossref","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","article-title":"The Reactome pathway knowledgebase","volume":"46","author":"Fabregat","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2023053116494955900_ref4","first-page":"34","article-title":"PubChemRDF: towards the semantic annotation of PubChem compound and substance databases","volume":"7","author":"Fu","year":"2015","journal-title":"J Chem"},{"issue":"D1","key":"2023053116494955900_ref5","doi-asserted-by":"crossref","first-page":"D1529","DOI":"10.1093\/nar\/gkaa947","article-title":"The international glycan repository GlyTouCan version 3.0","volume":"49","author":"Fujita","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"2023053116494955900_ref6","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.devcel.2021.02.023","article-title":"Global mapping of glycosylation pathways in human-derived cells","volume":"56","author":"Huang","year":"2021","journal-title":"Dev Cell"},{"issue":"11","key":"2023053116494955900_ref7","doi-asserted-by":"crossref","first-page":"167514","DOI":"10.1016\/j.jmb.2022.167514","article-title":"Feb. 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