{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:23:23Z","timestamp":1790760203556,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Z01-DE000713"],"award-info":[{"award-number":["Z01-DE000713"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Z01-ES025034"],"award-info":[{"award-number":["Z01-ES025034"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIDCR Veterinary Resources Core","award":["ZIC DE000740-05"],"award-info":[{"award-number":["ZIC DE000740-05"]}]},{"name":"NIDCR Imaging Core","award":["DE000750-01"],"award-info":[{"award-number":["DE000750-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The COVID-19 global pandemic has underscored the need to understand how viruses and other pathogens are able to infect and replicate within the respiratory system. Recent studies have highlighted the role of highly O-glycosylated mucins in the protection of the respiratory system as well as how mucin-type O-glycosylation may be able to modify viral infectivity. Therefore, we set out to identify the specific genes controlling mucin-type O-glycosylation throughout the mouse respiratory system as well as determine how their expression and the expression of respiratory mucins is influenced by infection or injury. Here, we show that certain mucins and members of the Galnt family are abundantly expressed in specific respiratory tissues\/cells and demonstrate unique patterns of O-glycosylation across diverse respiratory tissues. Moreover, we find that the expression of certain Galnts and mucins is altered during lung infection and injury in experimental mice challenged with infectious agents, toxins, and allergens. Finally, we examine gene expression changes of Galnts and mucins in a mouse model of SARS-CoV-2 infection. Our work provides foundational knowledge regarding the specific expression of Galnt enzyme family members and mucins throughout the respiratory system, and how their expression is altered upon lung infection and injury.<\/jats:p>","DOI":"10.1093\/glycob\/cwad031","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T17:26:25Z","timestamp":1682702785000},"source":"Crossref","is-referenced-by-count":5,"title":["Dynamic expression of mucins and the genes controlling mucin-type O-glycosylation within the mouse respiratory system"],"prefix":"10.1093","author":[{"given":"E","family":"Tian","sequence":"first","affiliation":[{"name":"Developmental Glycobiology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health , Bethesda, MD 20892-4370 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulfeqhar A","family":"Syed","sequence":"additional","affiliation":[{"name":"Developmental Glycobiology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health , Bethesda, MD 20892-4370 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L","family":"Edin","sequence":"additional","affiliation":[{"name":"Division of Intramural Research, NIEHS, National Institutes of Health, Research Triangle Park , Durham, NC 27514 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl C","family":"Zeldin","sequence":"additional","affiliation":[{"name":"Division of Intramural Research, NIEHS, National Institutes of Health, Research Triangle Park , Durham, NC 27514 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly G","family":"Ten Hagen","sequence":"additional","affiliation":[{"name":"Developmental Glycobiology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health , Bethesda, MD 20892-4370 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"issue":"16","key":"2023051619093697500_ref1","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.jmb.2016.02.010","article-title":"The densely O-glycosylated MUC2 mucin protects the intestine and provides food for the commensal bacteria","volume":"428","author":"Arike","year":"2016","journal-title":"J Mol Biol"},{"key":"2023051619093697500_ref2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fnana.2014.00063","article-title":"Anatomy, histochemistry, and immunohistochemistry of the olfactory subsystems in mice","volume":"8","author":"Barrios","year":"2014","journal-title":"Front Neuroanat"},{"issue":"6","key":"2023051619093697500_ref3","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/glycob\/cwr182","article-title":"Control of mucin-type O-glycosylation: a classification of the polypeptide 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