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We have previously isolated a sunflower mannose-binding lectin (Helja) with antifungal activity against Candida albicans, capable of binding mannose-bearing oligosaccharides exposed on the cell surface. This work aimed to investigate the biological and biophysical basis of Helja\u2019s binding to C. albicans cell wall mannans and its influence on the fungicidal activity of the lectin. We evaluated the interaction of Helja with the cell wall mannans extracted from the isogenic parental strain (WT) and a glycosylation-defective C. albicans with altered cell wall phosphomannosylation (mnn4\u2206 null mutants) and investigated its antifungal effect. Helja exhibited stronger antifungal activity on the mutant strain, showing greater inhibition of fungal growth, loss of cell viability, morphological alteration, and formation of clusters with agglutinated cells. This differential biological activity of Helja was correlated with the biophysical parameters determined by solid phase assays and isothermal titration calorimetry, which demonstrated that the lectin established stronger interactions with the cell wall mannans of the mnn4\u2206 null mutant than with the WT strain. In conclusion, our results provide new evidence on the nature of the Helja molecular interactions with cell wall components, i.e. phosphomannan, and its impact on the antifungal activity. This study highlights the relevance of plant lectins in the design of effective antifungal therapies.<\/jats:p>","DOI":"10.1093\/glycob\/cwae058","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T01:39:50Z","timestamp":1722476390000},"source":"Crossref","is-referenced-by-count":2,"title":["The sunflower jacalin Helja: biological and structural insights of its antifungal activity against <i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-1914","authenticated-orcid":false,"given":"Marianela V","family":"Del R\u00edo","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biol\u00f3gicas, Universidad Nacional de Mar del Plata - Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Funes 3250, Mar del Plata 7600, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4049-7043","authenticated-orcid":false,"given":"Melisa B","family":"Radicioni","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biol\u00f3gicas, Universidad Nacional de Mar del Plata - Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Funes 3250, Mar del Plata 7600, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-175X","authenticated-orcid":false,"given":"Anabela M","family":"Cutine","sequence":"additional","affiliation":[{"name":"Laboratorio de Glic\u00f3mica Funcional y Molecular , Instituto de Biolog\u00eda y Medicina Experimental, , Buenos Aires, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Vuelta de Obligado 2490, C1428ADN , Instituto de Biolog\u00eda y Medicina Experimental, , Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-8640","authenticated-orcid":false,"given":"Karina V","family":"Mari\u00f1o","sequence":"additional","affiliation":[{"name":"Laboratorio de Glic\u00f3mica Funcional y Molecular , Instituto de Biolog\u00eda y Medicina Experimental, , Buenos Aires, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Vuelta de Obligado 2490, C1428ADN , Instituto de Biolog\u00eda y Medicina Experimental, , Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-0595","authenticated-orcid":false,"given":"H\u00e9ctor M","family":"Mora-Montes","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda, Universidad de Guanajuato , Noria Alta s\/n, col. Noria Alta, Guanajuato, Gto, C.P. 36050, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-5841","authenticated-orcid":false,"given":"Alejandro J","family":"Cagnoni","sequence":"additional","affiliation":[{"name":"Laboratorio de Glic\u00f3mica Funcional y Molecular , Instituto de Biolog\u00eda y Medicina Experimental, , Buenos Aires, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Vuelta de Obligado 2490, C1428ADN , Instituto de Biolog\u00eda y Medicina Experimental, , Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-6114","authenticated-orcid":false,"given":"Mariana C","family":"Regente","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biol\u00f3gicas, Universidad Nacional de Mar del Plata - Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Funes 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