{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:24:17Z","timestamp":1791415457163,"version":"4.3.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"JSPS KAKENHI","award":["JP19KK0195"],"award-info":[{"award-number":["JP19KK0195"]}]},{"name":"JSPS KAKENHI","award":["JP19K22490"],"award-info":[{"award-number":["JP19K22490"]}]},{"name":"JSPS KAKENHI","award":["JP19H03176"],"award-info":[{"award-number":["JP19H03176"]}]},{"name":"JSPS KAKENHI","award":["JP23K06099"],"award-info":[{"award-number":["JP23K06099"]}]},{"name":"JSPS KAKENHI","award":["JP24K08644"],"award-info":[{"award-number":["JP24K08644"]}]},{"name":"JSPS KAKENHI","award":["JP23K04970"],"award-info":[{"award-number":["JP23K04970"]}]},{"name":"JSPS KAKENHI","award":["JP23K16306"],"award-info":[{"award-number":["JP23K16306"]}]},{"name":"JSPS KAKENHI","award":["JP21H03183"],"award-info":[{"award-number":["JP21H03183"]}]},{"name":"JSPS KAKENHI","award":["JP23K18402"],"award-info":[{"award-number":["JP23K18402"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The prevalent human pathogen, mumps virus (MuV; orthorubulavirus parotitidis) causes various complications and serious sequelae, such as meningitis, encephalitis, deafness, and impaired fertility. Direct-acting antivirals (DAAs) targeting MuV which can prevent mumps and mumps-associated complications and sequelae are yet to be developed. Paramyxoviridae family members, such as MuV, possess viral surface hemagglutinin-neuraminidase (HN) protein with sialidase activity which facilitates efficient viral replication. Therefore, to develop DAAs targeting MuV we synthesized MuV sialidase inhibitors. It is proposed that the viral HN has a single functional site for N-acetylneuraminic acid (Neu5Ac) binding and sialidase activity. Further, the known MuV sialidase inhibitor is an analog of Neu5Ac\u20142,3-didehydro-2-deoxy-N-acetylneuraminic acid (DANA)\u2014which lacks potency. DANA derivatives with higher MuV sialidase inhibitory potency are lacking. The MuV-HN\u2013Neu5Ac binding site has a hydrophobic cavity adjacent to the C4 position of Neu5Ac. Exploiting this, here, we synthesized DANA derivatives with increasing hydrophobicity at its C4 position and created 3 novel sialidase inhibitors (Compounds 1, 2, and 3) with higher specificity for MuV-HN than DANA; they inhibited MuV replication step to greater extent than DANA. Furthermore, they also inhibited hemagglutination and the MuV infection step. The insight\u2014that these 3 novel DANA derivatives possess linear hydrocarbon groups at the C4-hydroxyl group of DANA\u2014could help develop highly potent sialidase inhibitors with high specificity for MuV sialidase, which may function as direct-acting MuV-specific antivirals.<\/jats:p>","DOI":"10.1093\/glycob\/cwae059","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T21:37:22Z","timestamp":1722548242000},"source":"Crossref","is-referenced-by-count":5,"title":["Novel sialidase inhibitors suppress mumps virus replication and infection"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-6066","authenticated-orcid":false,"given":"Tadanobu","family":"Takahashi","sequence":"first","affiliation":[{"name":"University of Shizuoka Department of Biochemistry, School of Pharmaceutical Sciences, , 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-6160","authenticated-orcid":false,"given":"Yuuki","family":"Kurebayashi","sequence":"additional","affiliation":[{"name":"University of Shizuoka Department of Biochemistry, School of Pharmaceutical Sciences, , 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-9780","authenticated-orcid":false,"given":"Tadamune","family":"Otsubo","sequence":"additional","affiliation":[{"name":"Hiroshima International University Department of Organic Chemistry, School of Pharmaceutical Sciences, , 5-1-1 Hirokoshinkai, Kure, Hiroshima 737-0112,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Hiroshima International University Department of Organic Chemistry, School of Pharmaceutical Sciences, , 5-1-1 Hirokoshinkai, Kure, Hiroshima 737-0112,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kobun","family":"Konagaya","sequence":"additional","affiliation":[{"name":"University of Shizuoka Department of Biochemistry, School of Pharmaceutical Sciences, , 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"University of Shizuoka Department of Biochemistry, School of Pharmaceutical Sciences, , 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"University of Shizuoka Department of Biochemistry, School of Pharmaceutical Sciences, , 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"University of Shizuoka Department of Biochemistry, School of Pharmaceutical Sciences, , 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Narimichi","sequence":"additional","affiliation":[{"name":"University of Shizuoka Department of Biochemistry, School of Pharmaceutical Sciences, , 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8593-941X","authenticated-orcid":false,"given":"Akira","family":"Minami","sequence":"additional","affiliation":[{"name":"University of Shizuoka Department of Biochemistry, School of Pharmaceutical Sciences, , 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526,","place":["Japan"]},{"name":"Juntendo University Department of Functional Morphology, Faculty of Pharmacy, , 6-8-1 Hinode, Urayasu, Chiba 279-0013,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-5850","authenticated-orcid":false,"given":"Hideyuki","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"University of Shizuoka Department of Biochemistry, School of Pharmaceutical Sciences, , 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"issue":"5","key":"2024093023255198700_ref2","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1128\/AAC.48.5.1495-1502.2004","article-title":"Efficacy of novel hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 against human parainfluenza viruses in vitro and in 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