{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:10:44Z","timestamp":1779117044323,"version":"3.51.4"},"reference-count":94,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LTGY24H040005"],"award-info":[{"award-number":["LTGY24H040005"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LTGY23H040004"],"award-info":[{"award-number":["LTGY23H040004"]}]},{"name":"The Science and Technology Department of Shaoxing, China","award":["2025A14003"],"award-info":[{"award-number":["2025A14003"]}]},{"name":"Zhejiang University Shaoxing Research Institute\u2013Shaoxing Maternal and Child Health Care Hospital Joint Research Grant for Life and Health","award":["2025SMJK004"],"award-info":[{"award-number":["2025SMJK004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>N-Acetylglucosaminyltransferase V (GnT-V) is a pivotal glycosyltransferase catalyzing the formation of \u03b21\u20136 branched N-glycans, a structural modification intimately linked to cancer malignancy. While elevated GnT-V expression correlates with metastasis in breast, gastric, and colorectal cancers, its function is context-dependent, predicting distinct outcomes in lung and bladder cancers. Crucially, the oncogenic potential of GnT-V is not isolated but is dynamically regulated by its competitive interplay with GnT-III and cooperation with \u03b11,6-fucosyltransferase 8 (Fut8). Distinct from previous summaries, this review systematically dissects the molecular signaling networks driving these pathologies. Beyond well-known pathways like Wnt\/\u03b2-catenin and receptor stabilization (EGFR, HER-2), we highlight emerging evidence regarding the role of GnT-V in promoting resistance to anoikis and facilitating immune evasion. Furthermore, we detail how GnT-V orchestrates the epithelial\u2013mesenchymal transition (EMT) and cytoskeletal remodeling via the RhoA\/Rac1 axis. By integrating these signaling networks with the enzyme's regulatory environment, we provide a comprehensive roadmap of GnT-V pathogenesis and propose that targeting the GnT-V\/GnT-III balance represents a promising strategy for precise cancer diagnosis and therapy.<\/jats:p>","DOI":"10.1093\/glycob\/cwag036","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:42:43Z","timestamp":1778067763000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect and molecular mechanism of N-Acetylglucosamine transferase-V in the pathogenesis of cancers"],"prefix":"10.1093","volume":"36","author":[{"given":"Feng","family":"Zhang","sequence":"first","affiliation":[{"name":"Shaoxing Maternity and Child Health Care Hospital, Maternity and Child Health Care Affiliated Hospital, Shaoxing University , No. 222, Fenglin East Road, Doumen Street, Yuecheng District, Shaoxing , Zhejiang, 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