{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:08:40Z","timestamp":1785528520999,"version":"3.56.0"},"reference-count":291,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NEYE Foundation, Lundbeck Foundation","award":["R223-2016-563"],"award-info":[{"award-number":["R223-2016-563"]}]},{"DOI":"10.13039\/501100004836","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["2066-00043B"],"award-info":[{"award-number":["2066-00043B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["DNRF196"],"award-info":[{"award-number":["DNRF196"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Friis Foundation, Leo Foundation, and European Commission","award":["101161353"],"award-info":[{"award-number":["101161353"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aberrant O-GalNAc glycans such as Tn, STn, and T are among the most consistent tumor-associated carbohydrate antigens, broadly expressed on carcinomas but largely absent from healthy epithelia. In parallel, O-glycans can also be modified to carry functional motifs, such as Lewis antigens. Rather than a simple shift from elongated to truncated structures, cancer-associated O-glycans form a heterogeneous repertoire of truncated and elongated glycoforms that coexist across the tumor glycocalyx. Collectively, both short and elongated cancer-associated O-glycans co-drive tumor formation through their simultaneous influence on multiple cancer hallmarks, including adhesion, receptor signaling, dissemination, and immune evasion. The latter occurs through interactions with glycan-binding proteins including Selectins, Siglecs, macrophage galactose-type lectin (MGL), and galectins. The stable expression of especially truncated O-glycans across cancer stages, as well as their driving influence on cancer progression, make short, truncated O-glycans attractive therapeutic targets. While early vaccine approaches had limited efficacy, strategies that couple O-glycan recognition with potent effector mechanisms have shown promise. This includes O-glycan-directed chimeric antigen receptor T cells (CARTs), T-cell bispecifics (TCBs), and particularly antibody-drug conjugates (ADCs), which have demonstrated strong preclinical activity. Looking forward, multi-specific antibodies, bio-orthogonal chemistry, and artificial intelligence\u2013driven engineering are expected to enhance safety, selectivity, and improve patient stratification, helping to further exploit O-GalNAc glycans in precision oncology.<\/jats:p>","DOI":"10.1093\/glycob\/cwag049","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:42:14Z","timestamp":1782214934000},"source":"Crossref","is-referenced-by-count":1,"title":["Cancer-associated alterations in O-GalNAc glycosylation"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5329-1209","authenticated-orcid":false,"given":"Jos\u00e9","family":"Pires","sequence":"first","affiliation":[{"name":"Copenhagen Center for Glycocalyx Research, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rochat","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Glycocalyx Research, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieva","family":"Bagdonaite","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Glycocalyx Research, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Dabelsteen","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Glycocalyx Research, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen,","place":["Denmark"]},{"name":"Department of Oral Pathology, School of Dentistry, University of Copenhagen , N\u00f8rre All\u00e9 20, 2200 Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0240-9232","authenticated-orcid":false,"given":"Hans H","family":"Wandall","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Glycocalyx Research, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"2026073104425684400_ref1","article-title":"From Glycocode to precision oncology: therapeutic strategies targeting aberrant O-GalNAc glycosylation in cancer","author":"Aasted","year":"2026,","journal-title":"Chem Rev"},{"key":"2026073104425684400_ref2","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1158\/1535-7163.MCT-23-0221","article-title":"Targeting solid cancers with a cancer-specific monoclonal antibody to surface expressed aberrantly O-glycosylated 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