{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:33:09Z","timestamp":1787772789991,"version":"build-2784847793"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI171628"],"award-info":[{"award-number":["AI171628"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate the roles of the \u03b12,3-sialyltransferase ST3Gal1 and the \u03b12,6-sialyltransferase ST6Gal1 in T cell-mediated tumor control, we generated mice with mature T cell-specific deletion of ST3Gal1 (T-ST3KO) or ST6Gal1 (T-ST6KO) using distal Lck-Cre-mediated recombination. Deletion of ST3Gal1 in mature T cells did not affect thymic T cell development but resulted in a reduction of peripheral CD8+ T cells. In contrast, ST6Gal1 deletion had minimal impact on T cell development and peripheral T cell abundance. Following in vitro stimulation of isolated T cells from T-ST3KO and parental wild type (WT) mice with anti-CD3 plus anti-CD28\/CD80-Fc, CD8+ T cells from T-ST3KO mice exhibited enhanced activation and an increased frequency of CD44 positive memory-like T cells, while comparison of T cells from T-ST6KO and the parental WT mice showed no significant changes. Despite the activated CD8+ T cell phenotype in T-ST3KO mice, subcutaneous MC38 tumors displayed accelerated growth. In contrast, tumor progression in T-ST6KO mice was unchanged from the parental WT mice. Notably, T-ST6KO mice developed increased pulmonary metastases following intravenous challenge with B16F10 melanoma cells, whereas metastatic burden was unaffected in T-ST3KO mice. These findings demonstrate distinct and non-redundant roles for ST3Gal1- and ST6Gal1-mediated sialylation in regulating T cell function and antitumor immunity and reveal context-dependent effects of T cell intrinsic sialylation in controlling primary tumor growth and metastatic dissemination.<\/jats:p>","DOI":"10.1093\/glycob\/cwag065","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:48:22Z","timestamp":1786798102000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of sialyltransferase deletion in mature T cells on control of subcutaneous and metastatic cancers"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-9444","authenticated-orcid":false,"given":"Xiaoshuang","family":"Wang","sequence":"first","affiliation":[{"name":"The School of Medicine, Nankai University , 94 Weijin Road, Tianjin 300071 ,","place":["China"]},{"name":"Department of Immunology and Microbiology, The Scripps Research Institute , 10555 N. Torrey Pines Road, La Jolla, CA 92037 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C","family":"Paulson","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute , 10555 N. Torrey Pines Road, La Jolla, CA 92037 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"issue":"35","key":"2026082615064769700_ref1","doi-asserted-by":"publisher","first-page":"36689","DOI":"10.1074\/jbc.M405629200","article-title":"Peanut agglutinin high phenotype of activated CD8+ T cells results from de novo synthesis of CD45 glycans","volume":"279","author":"Amado","year":"2004","journal-title":"J Biol Chem"},{"issue":"9","key":"2026082615064769700_ref2","doi-asserted-by":"publisher","first-page":"7469","DOI":"10.1074\/jbc.M209595200","article-title":"The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death","volume":"278","author":"Amano","year":"2003","journal-title":"J Biol Chem"},{"issue":"10","key":"2026082615064769700_ref3","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20230896","article-title":"Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development","volume":"221","author":"Baldwin","year":"2024","journal-title":"J Exp Med"},{"issue":"4","key":"2026082615064769700_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2026.111245","article-title":"Sialic acids modulate immune responses in cancer: therapeutic opportunities","volume":"302","author":"Bashian","year":"2026","journal-title":"J Biol Chem"},{"issue":"18","key":"2026082615064769700_ref5","doi-asserted-by":"publisher","first-page":"10793","DOI":"10.1074\/jbc.271.18.10793","article-title":"Characterization of terminal sialic acid linkages on human thymocytes. Correlation between lectin-binding phenotype and sialyltransferase expression","volume":"271","author":"Baum","year":"1996","journal-title":"J Biol Chem"},{"issue":"7","key":"2026082615064769700_ref6","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1007\/s00018-014-1799-5","article-title":"Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense","volume":"72","author":"Boligan","year":"2015","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"2026082615064769700_ref7","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1093\/intimm\/dxh344","article-title":"Sialylation regulates peripheral tolerance in CD4+ T cells","volume":"18","author":"Brennan","year":"2006","journal-title":"Int Immunol"},{"issue":"13","key":"2026082615064769700_ref8","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1158\/0008-5472.CAN-17-3376","article-title":"Sialic acid blockade suppresses tumor growth by enhancing T-cell-mediated tumor immunity","volume":"78","author":"Bull","year":"2018","journal-title":"Cancer Res"},{"issue":"6","key":"2026082615064769700_ref9","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.4049\/jimmunol.1600827","article-title":"Lck-driven Cre expression alters T cell development in the thymus and the frequencies and functions of peripheral T cell subsets","volume":"197","author":"Carow","year":"2016","journal-title":"J Immunol"},{"issue":"2","key":"2026082615064769700_ref10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.clim.2011.09.011","article-title":"Galectin-1 research in T cell immunity: past, present and future","volume":"142","author":"Cedeno-Laurent","year":"2012","journal-title":"Clin Immunol"},{"issue":"15","key":"2026082615064769700_ref11","doi-asserted-by":"publisher","first-page":"3534","DOI":"10.1182\/blood-2011-12-396457","article-title":"Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma","volume":"119","author":"Cedeno-Laurent","year":"2012","journal-title":"Blood"},{"issue":"34","key":"2026082615064769700_ref12","doi-asserted-by":"publisher","first-page":"14496","DOI":"10.1073\/pnas.0903497106","article-title":"Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse","volume":"106","author":"Chen","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2026082615064769700_ref13","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1749-6632.2011.06304.x","article-title":"T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival","volume":"1253","author":"Clark","year":"2012","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"2026082615064769700_ref14","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1093\/bjd\/ljad517","article-title":"The sialic acid-Siglec immune checkpoint: an opportunity to enhance immune responses and therapy effectiveness in melanoma","volume":"190","author":"Coccimiglio","year":"2024","journal-title":"Br J Dermatol"},{"issue":"16","key":"2026082615064769700_ref15","doi-asserted-by":"publisher","first-page":"6104","DOI":"10.1073\/pnas.0400851101","article-title":"Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact","volume":"101","author":"Collins","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2026082615064769700_ref16","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.4049\/jimmunol.177.4.2431","article-title":"Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans","volume":"177","author":"Comelli","year":"2006","journal-title":"J Immunol"},{"issue":"9","key":"2026082615064769700_ref17","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1002\/ijc.32084","article-title":"Disruption of sialic acid metabolism drives tumor growth by augmenting CD8(+) T cell apoptosis","volume":"144","author":"Cornelissen","year":"2019","journal-title":"Int J Cancer"},{"issue":"4","key":"2026082615064769700_ref18","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nri2056","article-title":"Siglecs and their roles in the immune system","volume":"7","author":"Crocker","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"2026082615064769700_ref19","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1021\/acscentsci.1c00525","article-title":"Sialic acid ligands of CD28 suppress Costimulation of T cells","volume":"7","author":"Edgar","year":"2021","journal-title":"ACS Cent Sci"},{"issue":"9","key":"2026082615064769700_ref20","doi-asserted-by":"publisher","first-page":"772","DOI":"10.4049\/immunohorizons.2100079","article-title":"Distal Lck promoter-driven Cre shows cell type-specific function in innate-like T cells","volume":"5","author":"Figueroa","year":"2021","journal-title":"Immunohorizons"},{"issue":"2\u20133","key":"2026082615064769700_ref21","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0925-4439(99)00067-8","article-title":"Mucin-type O-glycans and leukosialin","volume":"1455","author":"Fukuda","year":"1999","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"2026082615064769700_ref22","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1021\/acscentsci.5c00510","article-title":"Targeting sialidase to PD1 enhances T cell function and tumor control","volume":"11","author":"Garabedian","year":"2025","journal-title":"ACS Cent Sci"},{"issue":"6","key":"2026082615064769700_ref23","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1016\/S0021-9258(18)53540-7","article-title":"Regulation of alpha 2,3-sialyltransferase expression correlates with conversion of peanut agglutinin (PNA)+ to PNA- phenotype in developing thymocytes","volume":"268","author":"Gillespie","year":"1993","journal-title":"J Biol Chem"},{"issue":"12","key":"2026082615064769700_ref24","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1038\/s41589-020-0622-x","article-title":"Targeted glycan degradation potentiates the anticancer immune response in vivo","volume":"16","author":"Gray","year":"2020","journal-title":"Nat Chem Biol"},{"issue":"8","key":"2026082615064769700_ref25","doi-asserted-by":"publisher","first-page":"4504","DOI":"10.1073\/pnas.95.8.4504","article-title":"Immune regulation by the ST6Gal sialyltransferase","volume":"95","author":"Hennet","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"2026082615064769700_ref26","doi-asserted-by":"publisher","first-page":"5328","DOI":"10.4049\/jimmunol.177.8.5328","article-title":"Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death","volume":"177","author":"Hernandez","year":"2006","journal-title":"J Immunol"},{"issue":"4","key":"2026082615064769700_ref27","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/imm.13780","article-title":"Sialic acid in the regulation of blood cell production, differentiation and turnover","volume":"172","author":"Irons","year":"2024","journal-title":"Immunology"},{"issue":"7","key":"2026082615064769700_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115933","article-title":"Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans","volume":"44","author":"Izzati","year":"2025","journal-title":"Cell Rep"},{"key":"2026082615064769700_ops-bib-reference-rmsz8s4k2yjacpn9","doi-asserted-by":"publisher","volume-title":"Nat Rev Immunol","DOI":"10.1038\/nri3307"},{"issue":"12","key":"2026082615064769700_ref29","doi-asserted-by":"publisher","first-page":"7421","DOI":"10.4049\/jimmunol.176.12.7421","article-title":"The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development","volume":"176","author":"Kao","year":"2006","journal-title":"J Immunol"},{"issue":"25","key":"2026082615064769700_ref30","doi-asserted-by":"publisher","first-page":"9566","DOI":"10.1039\/D4SC00969J","article-title":"Anticancer approach by targeted activation of a global inhibitor of sialyltransferases with acrolein","volume":"15","author":"Kasahara","year":"2024","journal-title":"Chem Sci"},{"issue":"6","key":"2026082615064769700_ref31","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nri3667","article-title":"Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)","volume":"14","author":"Klein","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"2026082615064769700_ref32","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1080\/14728222.2025.2557281","article-title":"Disrupting Siglec-mediated interactions to develop immunotherapies for cancer treatment","volume":"29","author":"Laubli","year":"2025","journal-title":"Expert Rev Anti-Infect Ther"},{"issue":"7","key":"2026082615064769700_ref33","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1007\/s00262-019-02345-5","article-title":"Patterns of immune-cell infiltration in murine models of melanoma: roles of antigen and tissue site in creating inflamed tumors","volume":"68","author":"Leick","year":"2019","journal-title":"Cancer Immunol Immunother"},{"key":"2026082615064769700_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2024.101925","article-title":"Roles for Siglec-glycan interactions in regulating immune cells","volume":"77","author":"Lin","year":"2025","journal-title":"Semin Immunol"},{"key":"2026082615064769700_ref35","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.molimm.2018.06.003","article-title":"Galectin-7 promotes proliferation and Th1\/2 cells polarization toward Th1 in activated CD4+ T cells by inhibiting the TGFbeta\/Smad3 pathway","volume":"101","author":"Luo","year":"2018","journal-title":"Mol Immunol"},{"issue":"10","key":"2026082615064769700_ref36","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nri3737","article-title":"Siglec-mediated regulation of immune cell function in disease","volume":"14","author":"Macauley","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"2026082615064769700_ref37","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1093\/glycob\/cwn051","article-title":"Disruption of thymopoiesis in ST6Gal I-deficient mice","volume":"18","author":"Marino","year":"2008","journal-title":"Glycobiology"},{"issue":"4","key":"2026082615064769700_ref38","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S0092-8674(01)00577-3","article-title":"Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding","volume":"107","author":"Moody","year":"2001","journal-title":"Cell"},{"issue":"1","key":"2026082615064769700_ref39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1158\/2326-6066.CIR-16-0114","article-title":"Rational selection of syngeneic preclinical tumor models for immunotherapeutic drug discovery","volume":"5","author":"Mosely","year":"2017","journal-title":"Cancer Immunol Res"},{"issue":"11","key":"2026082615064769700_ref40","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1002\/eji.200838295","article-title":"Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function","volume":"38","author":"Motran","year":"2008","journal-title":"Eur J Immunol"},{"issue":"1","key":"2026082615064769700_ref41","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1189\/jlb.1105692","article-title":"Sialidase expression in activated human T lymphocytes influences production of IFN-gamma","volume":"81","author":"Nan","year":"2007","journal-title":"J Leukoc Biol"},{"issue":"10","key":"2026082615064769700_ref42","doi-asserted-by":"publisher","first-page":"5697","DOI":"10.4049\/jimmunol.167.10.5697","article-title":"CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans","volume":"167","author":"Nguyen","year":"2001","journal-title":"J Immunol"},{"issue":"7","key":"2026082615064769700_ref43","doi-asserted-by":"publisher","DOI":"10.1002\/eji.70000","article-title":"The tumour Glyco-code: sialylation as a mediator of stromal cell immunosuppression in the tumour microenvironment","volume":"55","author":"O'Neill","year":"2025","journal-title":"Eur J Immunol"},{"issue":"5","key":"2026082615064769700_ref44","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1093\/glycob\/cwz096","article-title":"Modulation of hepatocyte sialylation drives spontaneous fatty liver disease and inflammation","volume":"30","author":"Oswald","year":"2020","journal-title":"Glycobiology"},{"issue":"2","key":"2026082615064769700_ref45","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/glycob\/cwv097","article-title":"Sialic acids in cancer biology and immunity","volume":"26","author":"Pearce","year":"2016","journal-title":"Glycobiology"},{"issue":"6","key":"2026082615064769700_ref46","doi-asserted-by":"publisher","first-page":"e012391","DOI":"10.1136\/jitc-2025-012391","article-title":"Tumor glyco-immunology, glyco-immune checkpoints and immunotherapy","volume":"13","author":"Pinho","year":"2025","journal-title":"J Immunother Cancer"},{"issue":"3","key":"2026082615064769700_ref47","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S1074-7613(00)80180-6","article-title":"The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis","volume":"12","author":"Priatel","year":"2000","journal-title":"Immunity"},{"issue":"19","key":"2026082615064769700_ref48","doi-asserted-by":"publisher","first-page":"5085","DOI":"10.1182\/bloodadvances.2025015980","article-title":"Targeting Siglec-sialic acid checkpoint to reverse immune dysfunction mediated by plasmacytoid dendritic cells in myeloma","volume":"9","author":"Ray","year":"2025","journal-title":"Blood Adv"},{"issue":"2","key":"2026082615064769700_ref49","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/icb.2015.72","article-title":"Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFbeta signaling","volume":"94","author":"Sampson","year":"2016","journal-title":"Immunol Cell Biol"},{"issue":"2","key":"2026082615064769700_ref50","doi-asserted-by":"publisher","first-page":"e000588","DOI":"10.1136\/jitc-2020-000588","article-title":"Monocyte-derived APCs are central to the response of PD1 checkpoint blockade and provide a therapeutic target for combination therapy","volume":"8","author":"Schetters","year":"2020","journal-title":"J Immunother Cancer"},{"key":"2026082615064769700_ref51","doi-asserted-by":"publisher","first-page":"1359494","DOI":"10.3389\/fimmu.2024.1359494","article-title":"Sialic acids on T cells are crucial for their maintenance and survival","volume":"15","author":"Schmidt","year":"2024","journal-title":"Front Immunol"},{"key":"2026082615064769700_ref52","doi-asserted-by":"publisher","first-page":"1429302","DOI":"10.3389\/fimmu.2024.1429302","article-title":"alpha2,6 sialylation distinguishes a novel active state in CD4(+) and CD8(+) cells during acute toxoplasma gondii infection","volume":"15","author":"Sierra-Ulloa","year":"2024","journal-title":"Front Immunol"},{"issue":"669","key":"2026082615064769700_ref53","doi-asserted-by":"publisher","first-page":"eabj1270","DOI":"10.1126\/scitranslmed.abj1270","article-title":"Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade","volume":"14","author":"Stanczak","year":"2022","journal-title":"Sci Transl Med"},{"issue":"10","key":"2026082615064769700_ref54","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1093\/glycob\/cwq214","article-title":"Galectin-9 regulates T helper cell function independently of Tim-3","volume":"21","author":"Su","year":"2011","journal-title":"Glycobiology"},{"issue":"8","key":"2026082615064769700_ref55","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/ni1482","article-title":"Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death","volume":"8","author":"Toscano","year":"2007","journal-title":"Nat Immunol"},{"issue":"8","key":"2026082615064769700_ref56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25084283","article-title":"Development of a novel, potent, and selective Sialyltransferase inhibitor for suppressing cancer metastasis","volume":"25","author":"Tsai","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2026082615064769700_ref57","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1749-6632.2012.06517.x","article-title":"Multifarious roles of sialic acids in immunity","volume":"1253","author":"Varki","year":"2012","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"2026082615064769700_ref58","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.4049\/jimmunol.181.4.2265","article-title":"Thymic emigration: when and how T cells leave home","volume":"181","author":"Weinreich","year":"2008","journal-title":"J Immunol"},{"issue":"24","key":"2026082615064769700_ref59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI180282","article-title":"Sialylated glycoproteins suppress immune cell killing by binding to Siglec-7 and Siglec-9 in prostate cancer","volume":"134","author":"Wen","year":"2024","journal-title":"J Clin Invest"},{"issue":"5","key":"2026082615064769700_ref60","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.jhep.2024.01.028","article-title":"Increased Siglec-9\/Siglec-9L interactions on NK cells predict poor HCC prognosis and present a targetable checkpoint for immunotherapy","volume":"80","author":"Xiao","year":"2024","journal-title":"J Hepatol"},{"issue":"5","key":"2026082615064769700_ref61","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41551-024-01202-w","article-title":"Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager","volume":"8","author":"Yang","year":"2024","journal-title":"Nat Biomed Eng"},{"key":"2026082615064769700_ref62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076501","article-title":"Galectin-1: a traditionally immunosuppressive protein displays context-dependent capacities","volume":"24","author":"Yu","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"11","key":"2026082615064769700_ref63","doi-asserted-by":"publisher","first-page":"6725","DOI":"10.4049\/jimmunol.174.11.6725","article-title":"Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene","volume":"174","author":"Zhang","year":"2005","journal-title":"J Immunol"},{"issue":"39","key":"2026082615064769700_ref64","doi-asserted-by":"publisher","first-page":"eadw6755","DOI":"10.1126\/sciadv.adw6755","article-title":"Age-related remodeling of the sialoglycans dampens murine CD8(+) T cell function","volume":"11","author":"Zhang","year":"2025","journal-title":"Sci Adv"},{"issue":"Pt 4","key":"2026082615064769700_ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136635","article-title":"A bispecific antibody targeting the Ig domains of Siglec-E displays enhanced antitumor effects","volume":"281","author":"Zhao","year":"2024","journal-title":"Int J Biol Macromol"}],"container-title":["Glycobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/glycob\/advance-article-pdf\/doi\/10.1093\/glycob\/cwag065\/70709202\/cwag065.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/glycob\/article-pdf\/36\/10\/cwag065\/70709202\/cwag065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/glycob\/article-pdf\/36\/10\/cwag065\/70709202\/cwag065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:12:38Z","timestamp":1787771558000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/glycob\/article\/doi\/10.1093\/glycob\/cwag065\/8766081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,8,23]]}},"URL":"https:\/\/doi.org\/10.1093\/glycob\/cwag065","relation":{},"ISSN":["1460-2423"],"issn-type":[{"value":"1460-2423","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,8,19]]},"article-number":"cwag065"}}