{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:06:34Z","timestamp":1790345194291,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Macrophages are central effectors of the immune system. These cells exhibit a wide range of functions, including inflammation, phagocytosis, antigen presentation, cytokine secretion, and tissue repair, all of which are tightly coupled to their metabolic state. O-GlcNAcylation, a reversible post-translational modification catalyzed exclusively by OGT and OGA, integrates glucose flux through the hexosamine biosynthetic pathway with the regulation of key immune mechanisms. This review evaluates the effect of O-GlcNAcylation on the expression and localization of pattern recognition receptors, endosome maturation, phagocytic capacity, reactive oxygen species production, and pro- and anti-inflammatory polarization.<\/jats:p>","DOI":"10.1093\/glycob\/cwag084","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:28:59Z","timestamp":1790335739000},"source":"Crossref","is-referenced-by-count":0,"title":["O-GlcNAcylation in Macrophage Functions"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-3933","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"S\u00e1nchez-Salgado","sequence":"first","affiliation":[{"name":"Laboratorio 6, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]},{"name":"Laboratorio Internacional Gly-CRRET-UNAM, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u00ed","family":"Pereyra","sequence":"additional","affiliation":[{"name":"Laboratorio 6, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]},{"name":"Laboratorio Internacional Gly-CRRET-UNAM, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilton","family":"Henao","sequence":"additional","affiliation":[{"name":"Laboratorio 6, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]},{"name":"Laboratorio Internacional Gly-CRRET-UNAM, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johana","family":"Torres-Barr\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio 6, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]},{"name":"Laboratorio Internacional Gly-CRRET-UNAM, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Ortiz-Chavez","sequence":"additional","affiliation":[{"name":"Laboratorio 6, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]},{"name":"Laboratorio Internacional Gly-CRRET-UNAM, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleazar","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Laboratorio 6, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]},{"name":"Laboratorio Internacional Gly-CRRET-UNAM, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar Zenteno","family":"Galindo","sequence":"additional","affiliation":[{"name":"Laboratorio 6, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]},{"name":"Laboratorio Internacional Gly-CRRET-UNAM, Departamento de Bioqu\u00edmica, Facultad de Medicina, UNAM ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,25]]},"container-title":["Glycobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/glycob\/advance-article-pdf\/doi\/10.1093\/glycob\/cwag084\/71395753\/cwag084.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/glycob\/advance-article-pdf\/doi\/10.1093\/glycob\/cwag084\/71395753\/cwag084.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:53:14Z","timestamp":1790344394000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/glycob\/advance-article\/doi\/10.1093\/glycob\/cwag084\/8835748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/glycob\/cwag084","relation":{},"ISSN":["1460-2423"],"issn-type":[{"value":"1460-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"article-number":"cwag084"}}