{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:34:06Z","timestamp":1790775246885,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"DOI":"10.1093\/glycob\/cwm008","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T05:49:04Z","timestamp":1169704144000},"page":"467-478","source":"Crossref","is-referenced-by-count":106,"title":["Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease"],"prefix":"10.1093","volume":"17","author":[{"given":"Scott M.","family":"Van Patten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Huff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Piepenhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Waire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrashekar","family":"Ganesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Reczek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul V.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Kutzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Edmunds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,1,24]]},"reference":[{"key":"key\n\t\t\t\t20171010215455_CWM008C1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0092-8674(78)90102-2","article-title":"Human beta-glucuronidase: in vivo clearance and in vitro uptake by a glycoprotein recognition system on reticuloendothelial cells","volume":"15","author":"Achord","year":"1978","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171010215455_CWM008C2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/A:1026488408951","article-title":"Insect cells as hosts for the expression of recombinant glycoproteins","volume":"16","author":"Altmann","year":"1999","journal-title":"Glycoconj J"},{"key":"key\n\t\t\t\t20171010215455_CWM008C3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/glycob\/8.7.685","article-title":"High resolution and high sensitivity methods for oligosaccharide mapping and characterization by normal phase high performance liquid chromatography following derivatization with highly fluorescent anthranilic acid","volume":"8","author":"Anumula","year":"1998","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20171010215455_CWM008C4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/glycob\/cwg024","article-title":"Immunoreactivity in mammals of two typical plant glyco-epitopes, core alpha(1,3)-fucose and core xylose","volume":"13","author":"Bardor","year":"2003","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20171010215455_CWM008C5","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJM199105233242104","article-title":"Replacement therapy for inherited enzyme deficiency\u2013macrophage-targeted glucocerebrosidase for Gaucher's disease","volume":"324","author":"Barton","year":"1991","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20171010215455_CWM008C6","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1073\/pnas.87.5.1913","article-title":"Therapeutic response to intravenous infusions of glucocerebrosidase in a patient with Gaucher disease","volume":"87","author":"Barton","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20171010215455_CWM008C7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0268-960X(88)90009-4","article-title":"Gaucher disease","volume":"2","author":"Beutler","year":"1988","journal-title":"Blood Rev"},{"key":"key\n\t\t\t\t20171010215455_CWM008C8","first-page":"3635","article-title":"Gaucher disease","volume-title":"The metabolic and molecular bases of inherited disease","author":"Beutler","year":"2001"},{"key":"key\n\t\t\t\t20171010215455_CWM008C9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/BF00711365","article-title":"Modifying exogenous glucocerebrosidase for effective replacement therapy in Gaucher disease","volume":"17","author":"Brady","year":"1994","journal-title":"J Inherit Metab Dis"},{"key":"key\n\t\t\t\t20171010215455_CWM008C10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0958-1669(02)00330-0","article-title":"Production of recombinant proteins in fermenter cultures of the yeast Pichia pastoris","volume":"13","author":"Cereghino","year":"2002","journal-title":"Curr Opin Biotechnol"},{"key":"key\n\t\t\t\t20171010215455_CWM008C11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ab.2004.08.031","article-title":"Measurement of lysosomal glucocerebrosidase activity in mouse liver using a fluorescence-activated cell sorter assay","volume":"334","author":"Chan","year":"2004","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20171010215455_CWM008C12","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1016\/S0021-9258(18)67420-4","article-title":"Lec1A Chinese hamster ovary cell mutants appear to arise from a structural alteration in N-acetylglucosaminyltransferase I","volume":"261","author":"Chaney","year":"1986","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171010215455_CWM008C13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1749-6632.1996.tb32492.x","article-title":"Bioproduction of human enzymes in transgenic tobacco","volume":"792","author":"Cramer","year":"1996","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20171010215455_CWM008C14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1086\/498652","article-title":"The role of mannosylated enzyme and the mannose receptor in enzyme replacement therapy","volume":"77","author":"Du","year":"2005","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20171010215455_CWM008C15","doi-asserted-by":"crossref","first-page":"15599","DOI":"10.1016\/S0021-9258(18)55439-9","article-title":"Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I","volume":"265","author":"Elbein","year":"1990","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171010215455_CWM008C16","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1182\/blood.V93.9.2807","article-title":"A comparison of the pharmacological properties of carbohydrate remodeled recombinant and placental-derived beta-glucocerebrosidase: implications for clinical efficacy in treatment of Gaucher disease","volume":"93","author":"Friedman","year":"1999","journal-title":"Blood"},{"key":"key\n\t\t\t\t20171010215455_CWM008C17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0304-4165(81)90474-8","article-title":"Uptake and distribution of placental glucocerebrosidase in rat hepatic cells and effects of sequential deglycosylation","volume":"673","author":"Furbish","year":"1981","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20171010215455_CWM008C18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.7326\/0003-4819-122-1-199501010-00005","article-title":"Enzyme therapy in type 1 Gaucher disease: comparative efficacy of mannose-terminated glucocerebrosidase from natural and recombinant sources","volume":"122","author":"Grabowski","year":"1995","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20171010215455_CWM008C19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0065-3527(06)68005-6","article-title":"Protein N-glycosylation in the baculovirus-insect cell expression system and engineering of insect cells to produce \u201cmammalianized\u201d recombinant glycoproteins","volume":"68","author":"Harrison","year":"2006","journal-title":"Adv Virus Res"},{"key":"key\n\t\t\t\t20171010215455_CWM008C20","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/bj3330601","article-title":"Orientation of sugars bound to the principal C-type carbohydrate-recognition domain of the macrophage mannose receptor","volume":"3","author":"Hitchen","year":"1998","journal-title":"Biochem J. 333 Pt"},{"key":"key\n\t\t\t\t20171010215455_CWM008C21","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/bit.20880","article-title":"Comparison of cell lines for stable production of fucose-negative antibodies with enhanced ADCC","volume":"94","author":"Kanda","year":"2006","journal-title":"Biotechnol Bioeng"},{"key":"key\n\t\t\t\t20171010215455_CWM008C22","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nbt1095","article-title":"Baculovirus as versatile vectors for protein expression in insect and mammalian cells","volume":"23","author":"Kost","year":"2005","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20171010215455_CWM008C23","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/glycob\/8.7.741","article-title":"N-linked glycosylation of a baculovirus-expressed recombinant glycoprotein in insect larvae and tissue culture cells","volume":"8","author":"Kulakosky","year":"1998","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20171010215455_CWM008C24","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/glycob\/4.6.895","article-title":"Core fucosylation of high-mannose-type oligosaccharides in GlcNAc transferase I-deficient (Lec1) CHO cells","volume":"4","author":"Lin","year":"1994","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20171010215455_CWM008C25","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1074\/jbc.M511110200","article-title":"Analyses of variant acid beta-glucosidases: effects of Gaucher disease mutations","volume":"281","author":"Liou","year":"2006","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171010215455_CWM008C26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/mthe.2002.0650","article-title":"Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model","volume":"6","author":"Marshall","year":"2002","journal-title":"Mol Ther"},{"key":"key\n\t\t\t\t20171010215455_CWM008C27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0304-4165(02)00199-X","article-title":"Serum mannan binding protein inhibits mannosylated liposome-mediated transfection to macrophages","volume":"1570","author":"Opanasopit","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20171010215455_CWM008C28","doi-asserted-by":"crossref","first-page":"G879","DOI":"10.1152\/ajpgi.2001.280.5.G879","article-title":"In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein","volume":"280","author":"Opanasopit","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key\n\t\t\t\t20171010215455_CWM008C29","doi-asserted-by":"crossref","first-page":"C1417","DOI":"10.1152\/ajpcell.1995.269.6.C1417","article-title":"Differential expression of Na+-K+-ATPase, ankyrin, fodrin, and E-cadherin along the kidney nephron","volume":"269","author":"Piepenhagen","year":"1995","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20171010215455_CWM008C30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1021\/cb600187q","article-title":"Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants","volume":"1","author":"Sawkar","year":"2006","journal-title":"ACS Chem Biol"},{"key":"key\n\t\t\t\t20171010215455_CWM008C31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S1046-5928(02)00526-0","article-title":"Synonymous codon usage bias and the expression of human glucocerebrosidase in the methylotrophic yeast, Pichia pastoris","volume":"26","author":"Sinclair","year":"2002","journal-title":"Protein Expr Purif"},{"key":"key\n\t\t\t\t20171010215455_CWM008C32","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1073\/pnas.75.3.1399","article-title":"Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages","volume":"75","author":"Stahl","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20171010215455_CWM008C33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0304-4165(99)00181-6","article-title":"Fucose in N-glycans: from plant to man","volume":"1473","author":"Staudacher","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20171010215455_CWM008C34","doi-asserted-by":"crossref","first-page":"10112","DOI":"10.1016\/S0021-9258(18)90936-1","article-title":"Structure of the N-asparagine-linked oligosaccharide units of human placental beta-glucocerebrosidase","volume":"259","author":"Takasaki","year":"1984","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171010215455_CWM008C35","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.4049\/jimmunol.174.5.2870","article-title":"The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases","volume":"174","author":"Teillet","year":"2005","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20171010215455_CWM008C36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000236534","article-title":"Fucose \u03b11,3-linked to the core region of glycoprotein N-glycans creates an important epitope for IgE from honeybee venom allergic individuals","volume":"102","author":"Tretter","year":"1993","journal-title":"Int Arch Allergy Immunol"},{"key":"key\n\t\t\t\t20171010215455_CWM008C37","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1432-1033.1991.tb16166.x","article-title":"Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase F cannot release glycans with fucose attached \u03b11-3 to the asparagine-linked N-acetylglucosamine residue","volume":"199","author":"Tretter","year":"1991","journal-title":"Eur J Biochem"},{"key":"key\n\t\t\t\t20171010215455_CWM008C38","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.tibtech.2003.10.002","article-title":"Molecular farming in plants: host systems and expression technology","volume":"21","author":"Twyman","year":"2003","journal-title":"Trends Biotechnol"},{"key":"key\n\t\t\t\t20171010215455_CWM008C39","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0002-9440(10)63566-3","article-title":"Viable mouse models of acid \u03b2-glucosidase deficiency: the defect in Gaucher disease","volume":"163","author":"Xu","year":"2003","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20171010215455_CWM008C40","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1074\/jbc.274.2.1164","article-title":"The rate of internalization of the mannose 6-phosphate\/insulin-like growth factor II receptor is enhanced by multivalent ligand binding","volume":"274","author":"York","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171010215455_CWM008C41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jbiotec.2005.01.001","article-title":"Effect of genetic background on glycosylation heterogeneity in human antithrombin produced in the mammary gland of transgenic goats","volume":"117","author":"Zhou","year":"2005","journal-title":"J Biotechnol"},{"key":"key\n\t\t\t\t20171010215455_CWM008C42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/abio.2002.5703","article-title":"Mannose 6-phosphate quantitation in glycoproteins using high-pH anion-exchange chromatography with pulsed amperometric detection","volume":"306","author":"Zhou","year":"2002","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20171010215455_CWM008C43","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1124\/jpet.103.060236","article-title":"Dexamethasone-mediated upregulation of the mannose receptor improves the delivery of recombinant glucocerebrosidase to Gaucher macrophages","volume":"308","author":"Zhu","year":"2003","journal-title":"J Pharmacol Exp Ther."}],"container-title":["Glycobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/glycob\/article-pdf\/17\/5\/467\/2227478\/cwm008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T03:03:23Z","timestamp":1628391803000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/glycob\/article\/17\/5\/467\/743365\/Effect-of-mannose-chain-length-on-targeting-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,24]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2007,1,24]]},"published-print":{"date-parts":[[2007,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/glycob\/cwm008","relation":{},"ISSN":["1460-2423","0959-6658"],"issn-type":[{"value":"1460-2423","type":"electronic"},{"value":"0959-6658","type":"print"}],"subject":[],"published-other":{"date-parts":[[2007,5]]},"published":{"date-parts":[[2007,1,24]]}}}