{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:42:52Z","timestamp":1776429772084,"version":"3.51.2"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-62,975"],"award-info":[{"award-number":["MOP-62,975"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chair","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Research Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1093\/glycob\/cwx035","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T03:48:13Z","timestamp":1492660093000},"page":"595-598","source":"Crossref","is-referenced-by-count":12,"title":["N-acetylglucosamine: more than a silent partner in insulin resistance"],"prefix":"10.1093","volume":"27","author":[{"given":"Geoffrey G","family":"Hesketh","sequence":"first","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Ave., Toronto, Canada ON M5G 1X5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W","family":"Dennis","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Ave., Toronto, Canada ON M5G 1X5"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Canada ON M5S 1A8"},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada ON M5S 1A8"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"key\n\t\t\t\t20180328180226_cwx035C1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/glycob\/cwu105","article-title":"Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism","volume":"25","author":"Abdel Rahman","year":"2015","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20180328180226_cwx035C2","doi-asserted-by":"crossref","first-page":"e21330","DOI":"10.7554\/eLife.21330","article-title":"Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation","volume":"6","author":"Araujo","year":"2017","journal-title":"Elife"},{"key":"key\n\t\t\t\t20180328180226_cwx035C3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrendo.2016.87","article-title":"The role of diet and exercise in the transgenerational epigenetic landscape of T2DM","volume":"12","author":"Barres","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"key\n\t\t\t\t20180328180226_cwx035C4","doi-asserted-by":"crossref","first-page":"41R","DOI":"10.1093\/glycob\/cwg054","article-title":"Fucose: Biosynthesis and biological function in mammals","volume":"13","author":"Becker","year":"2003","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20180328180226_cwx035C5","doi-asserted-by":"crossref","first-page":"e115662","DOI":"10.1371\/journal.pone.0115662","article-title":"Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume","volume":"9","author":"Bernelot Moens","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328180226_cwx035C6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrmicro3050","article-title":"The abundance and variety of carbohydrate-active enzymes in the human gut microbiota","volume":"11","author":"El Kaoutari","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180328180226_cwx035C7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature18642","article-title":"The genetic architecture of type 2 diabetes","volume":"536","author":"Fuchsberger","year":"2016","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328180226_cwx035C8","doi-asserted-by":"crossref","first-page":"1254009","DOI":"10.1126\/science.1254009","article-title":"Innate lymphoid cells regulate intestinal epithelial cell glycosylation","volume":"345","author":"Goto","year":"2014","journal-title":"Science"},{"key":"key\n\t\t\t\t20180328180226_cwx035C9","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.cmet.2012.03.015","article-title":"Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c","volume":"15","author":"Hagiwara","year":"2012","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180328180226_cwx035C10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cmet.2014.07.014","article-title":"Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation","volume":"20","author":"Hardiville","year":"2014","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180328180226_cwx035C11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.matbio.2014.01.014","article-title":"The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc","volume":"35","author":"Hascall","year":"2014","journal-title":"Matrix Biol"},{"key":"key\n\t\t\t\t20180328180226_cwx035C12","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1126\/science.1259472","article-title":"Metabolism. Differential regulation of mTORC1 by leucine and glutamine","volume":"347","author":"Jewell","year":"2015","journal-title":"Science"},{"key":"key\n\t\t\t\t20180328180226_cwx035C13","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1074\/jbc.M114.563734","article-title":"N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway","volume":"289","author":"Johswich","year":"2014","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328180226_cwx035C14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1875044301205010001","article-title":"Role of chitotriosidase (chitinase 1) under normal and disease conditions","volume":"5","author":"Kanneganti","year":"2012","journal-title":"J Epithel Biol Pharmacol"},{"key":"key\n\t\t\t\t20180328180226_cwx035C15","doi-asserted-by":"crossref","first-page":"17059","DOI":"10.1073\/pnas.1306070110","article-title":"Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota","volume":"110","author":"Kashyap","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328180226_cwx035C16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2007.01.049","article-title":"Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation","volume":"129","author":"Lau","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180328180226_cwx035C17","doi-asserted-by":"crossref","first-page":"e14814","DOI":"10.7554\/eLife.14814","article-title":"Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis","volume":"5","author":"Mkhikian","year":"2016","journal-title":"Elife"},{"key":"key\n\t\t\t\t20180328180226_cwx035C18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4161\/cib.19034","article-title":"Novel roles for GlcNAc in cell signaling","volume":"5","author":"Naseem","year":"2012","journal-title":"Commun Integr Biol"},{"key":"key\n\t\t\t\t20180328180226_cwx035C19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180328180226_cwx035C20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2008.11.044","article-title":"Bidirectional transport of amino acids regulates mTOR and autophagy","volume":"136","author":"Nicklin","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180328180226_cwx035C21","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.cell.2005.09.041","article-title":"Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes","volume":"123","author":"Ohtsubo","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180328180226_cwx035C22","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.1102109","article-title":"Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis","volume":"306","author":"Partridge","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20180328180226_cwx035C23","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328180226_cwx035C24","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature13823","article-title":"Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness","volume":"514","author":"Pickard","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328180226_cwx035C25","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature14107","article-title":"SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1","volume":"519","author":"Rebsamen","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328180226_cwx035C26","doi-asserted-by":"crossref","first-page":"23043","DOI":"10.1038\/srep23043","article-title":"Metabolic reprogramming by hexosamine biosynthetic and Golgi N-glycan branching pathways","volume":"6","author":"Ryczko","year":"2016","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180328180226_cwx035C27","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1038\/ncomms9285","article-title":"Baleen whales host a unique gut microbiome with similarities to both carnivores and herbivores","volume":"6","author":"Sanders","year":"2015","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20180328180226_cwx035C28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1043-4526(05)49003-8","article-title":"Chitin, chitosan, and co-products: Chemistry, production, applications, and health effects","volume":"49","author":"Shahidi","year":"2005","journal-title":"Adv Food Nutr Res"},{"key":"key\n\t\t\t\t20180328180226_cwx035C29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1126\/science.1257132","article-title":"Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1","volume":"347","author":"Wang","year":"2015","journal-title":"Science"},{"key":"key\n\t\t\t\t20180328180226_cwx035C30","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1101\/gad.1985910","article-title":"The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism","volume":"24","author":"Wellen","year":"2010","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180328180226_cwx035C31","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1101\/gr.120741.111","article-title":"Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis","volume":"21","author":"Yazbek","year":"2011","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20180328180226_cwx035C32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: From growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Glycobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/glycob\/article-pdf\/27\/7\/595\/19677952\/cwx035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T03:21:38Z","timestamp":1522293698000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/glycob\/article\/27\/7\/595\/3778501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,17]]},"references-count":32,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,5,17]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/glycob\/cwx035","relation":{},"ISSN":["0959-6658","1460-2423"],"issn-type":[{"value":"0959-6658","type":"print"},{"value":"1460-2423","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,5,17]]}}}