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The well-known immune-unrelated functions of macrophages include their roles in hematopoiesis, especially the quality control of hematopoietic stem cells (HSCs) and hematopoietic stem and progenitor cells (HSPCs), the support of erythropoiesis, and the regulation of megakaryopoiesis. Several studies, most using mouse models, have explored the roles of macrophages in hematopoiesis in different organs such as the yolk sac (YS), fetal liver (FL), bone marrow (BM), and spleen (SP). We have recently documented the potential roles and underlying mechanisms of macrophages in myeloproliferative neoplasm (MPN), aplastic anemia (AA), and idiopathic thrombocytopenic purpura (ITP). In this article, we review the origin of macrophages, introduce their roles in regulating HSCs\/HSPCs, erythropoiesis, and megakaryopoiesis within four hematopoietic organs, and summarize the recent advances of macrophages in MPN, AA, and ITP. Finally, we outline the unresolved questions that future studies should address to explore in greater depth the role of macrophages in both normal and disordered hematopoiesis.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzaf112","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:33:43Z","timestamp":1764092023000},"source":"Crossref","is-referenced-by-count":0,"title":["Macrophages in Hematopoiesis and Related Blood Diseases"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7978-5395","authenticated-orcid":false,"given":"Hong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital , Zhengzhou 450008,","place":["China"]},{"name":"Department of Hematology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6302-5432","authenticated-orcid":false,"given":"Mengya","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital , Zhengzhou 450008,","place":["China"]},{"name":"Department of Hematology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1631-8286","authenticated-orcid":false,"given":"Francesca","family":"Vinchi","sequence":"additional","affiliation":[{"name":"Laboratory of Iron Research, New York Blood Center , New York, NY 10065,","place":["USA"]},{"name":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine , New York, NY 10065,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3582-9404","authenticated-orcid":false,"given":"Xiuli","family":"An","sequence":"additional","affiliation":[{"name":"Laboratory of Membrane Biology, New York Blood Center , New York, NY 10065,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5550-508X","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0234-965X","authenticated-orcid":false,"given":"Yaomei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital , Zhengzhou 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