{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:27:21Z","timestamp":1793932041577,"version":"4.8.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270127"],"award-info":[{"award-number":["82270127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81920108004"],"award-info":[{"award-number":["81920108004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100137"],"award-info":[{"award-number":["82100137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770107"],"award-info":[{"award-number":["81770107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702722"],"award-info":[{"award-number":["81702722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470362"],"award-info":[{"award-number":["81470362"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870105"],"award-info":[{"award-number":["81870105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1804282"],"award-info":[{"award-number":["U1804282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2018YFA0107800"],"award-info":[{"award-number":["2018YFA0107800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Province Clinical Medical Technology Innovation Guidance","award":["2021SK50917"],"award-info":[{"award-number":["2021SK50917"]}]},{"name":"Hunan Province Clinical Medical Technology Innovation Guidance","award":["2023SK4056"],"award-info":[{"award-number":["2023SK4056"]}]},{"name":"Postgraduate Scientific Research Innovation Project of Hunan Province","award":["CX20210182"],"award-info":[{"award-number":["CX20210182"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Erythropoiesis is precisely regulated by multilayered networks. It is crucial for maintaining steady-state hemoglobin levels and ensuring effective oxygen transport. Alternative polyadenylation (APA) is a post-transcriptional regulatory mechanism generating multiple mRNA isoforms from a single gene based on specific 3\u2032 untranslated region sequences. While APA plays a vital role in various cellular processes, the underlying mechanism in erythropoiesis remains largely unexplored. In this study, we employed an integrative approach, combining bioinformatics analyses and experimental validations, to systematically investigate the role of APA in erythropoiesis. We mapped the APA landscape during erythroid differentiation and identified significant APA shifts essential for the differentiation of erythroid cells from burst-forming unit erythroid (BFU\u2013E) to colony-forming unit erythroid (CFU\u2013E). Notably, our findings highlighted polyadenylate-binding protein cytoplasmic 1 (PABPC1) as the primary regulator of APA during these stages. Functional analyses have revealed that knockdown of PABPC1 disrupts erythroid progenitor cell proliferation and differentiation. These results implicate an essential role of PABPC1 in modulating cell fate through APA regulation. Furthermore, we found that decreased PABPC1 levels increased the usage of the proximal polyadenylation sites in the TSC22 domain family member 1 (TSC22D1)\u00a0gene. This shift led to elevated expression of TSC22D1, uncovering a novel mechanism by which APA influences erythroid progenitor expansion and differentiation. Our findings provide novel insights into APA regulation in early erythropoiesis and suggest potential therapeutic strategies for diseases associated with erythropoietic disorders.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzaf116","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:33:45Z","timestamp":1764092025000},"source":"Crossref","is-referenced-by-count":4,"title":["Regulation of Alternative Polyadenylation Events by PABPC1 Affects Erythroid Progenitor Cell Expansion"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7821-8315","authenticated-orcid":false,"given":"Yanan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hematology, the Second Xiangya Hospital; Molecular Biology Research Center, Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University , Changsha 410013,","place":["China"]},{"name":"Department of Radiology, The Third Xiangya Hospital of Central South University , Changsha 410013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-2862","authenticated-orcid":false,"given":"Yanbo","family":"Yang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University , Wuhan 430070,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-3786","authenticated-orcid":false,"given":"Bin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology, the Second Xiangya Hospital; Molecular Biology Research Center, Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University , Changsha 410013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3892-827X","authenticated-orcid":false,"given":"Zi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, the Second Xiangya Hospital; Molecular Biology Research Center, Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University , Changsha 410013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3409-7846","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Third Xiangya Hospital of Central South University , Changsha 410013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1431-7308","authenticated-orcid":false,"given":"Xiaofeng","family":"He","sequence":"additional","affiliation":[{"name":"Shenzhen Health Development Research and Data Management Center , Shenzhen 518000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2651-0813","authenticated-orcid":false,"given":"Xusheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Shenzhen Health Development Research and Data Management Center , Shenzhen 518000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1076-5106","authenticated-orcid":false,"given":"Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Shenzhen Health Development Research and Data Management Center , Shenzhen 518000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-5296","authenticated-orcid":false,"given":"Narla","family":"Mohandas","sequence":"additional","affiliation":[{"name":"Research Laboratory of Red Cell Physiology, New York Blood Center , New York, NY 10065,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-2985","authenticated-orcid":false,"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Clinical Research Center for Cancer Immunotherapy, Furong Laboratory, Central South University , Changsha 410008,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1895-2993","authenticated-orcid":false,"given":"Jing","family":"Gong","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University , Wuhan 430070,","place":["China"]},{"name":"College of Biomedicine and Health, Huazhong Agricultural University , Wuhan 430072,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2538-6726","authenticated-orcid":false,"given":"Long","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematology, the Second Xiangya Hospital; Molecular Biology Research Center, Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University , Changsha 410013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5588-3865","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, the Second Xiangya Hospital; Molecular Biology Research Center, Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University , Changsha 410013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"2026060820234059800_qzaf116-B1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2013.08.007","article-title":"Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells","volume":"154","author":"Yamamoto","year":"2013","journal-title":"Cell"},{"key":"2026060820234059800_qzaf116-B2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41556-020-0512-1","article-title":"Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis","volume":"22","author":"Dong","year":"2020","journal-title":"Nat Cell Biol"},{"key":"2026060820234059800_qzaf116-B3","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1182\/blood-2014-07-588806","article-title":"Isolation and transcriptome analyses of human erythroid progenitors: BFU-E and CFU-E","volume":"124","author":"Li","year":"2014","journal-title":"Blood"},{"key":"2026060820234059800_qzaf116-B4","first-page":"150","article-title":"Post-transcriptional regulation of erythropoiesis","volume":"5","author":"Li","year":"2023","journal-title":"Blood Sci"},{"key":"2026060820234059800_qzaf116-B5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1182\/blood-2016-09-739268","article-title":"Unexpected role for p19INK4d in posttranscriptional regulation of GATA1 and modulation of human terminal erythropoiesis","volume":"129","author":"Han","year":"2017","journal-title":"Blood"},{"key":"2026060820234059800_qzaf116-B6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/bjh.18407","article-title":"Comprehensive proteomic analysis reveals dynamic phospho-profiling in human early erythropoiesis","volume":"199","author":"Peng","year":"2022","journal-title":"Br J Haematol"},{"key":"2026060820234059800_qzaf116-B7","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1182\/blood-2014-10-608042","article-title":"Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs","volume":"125","author":"Iskander","year":"2015","journal-title":"Blood"},{"key":"2026060820234059800_qzaf116-B8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/bjh.13938","article-title":"Advances in understanding erythropoiesis: evolving perspectives","volume":"173","author":"Nandakumar","year":"2016","journal-title":"Br J Haematol"},{"key":"2026060820234059800_qzaf116-B9","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.3324\/haematol.2020.248955","article-title":"Myelodysplastic syndromes: moving towards personalized management","volume":"105","author":"Hellstr\u00f6m-Lindberg","year":"2020","journal-title":"Haematologica"},{"key":"2026060820234059800_qzaf116-B10","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1182\/blood.2021011045","article-title":"Ineffective erythropoiesis and its treatment","volume":"139","author":"Cazzola","year":"2022","journal-title":"Blood"},{"key":"2026060820234059800_qzaf116-B11","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1182\/blood-2016-05-718320","article-title":"TGF-\u03b2 inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors","volume":"128","author":"Gao","year":"2016","journal-title":"Blood"},{"key":"2026060820234059800_qzaf116-B12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature12215","article-title":"ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors","volume":"499","author":"Zhang","year":"2013","journal-title":"Nature"},{"key":"2026060820234059800_qzaf116-B13","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41576-019-0145-z","article-title":"Alternative cleavage and polyadenylation in health and disease","volume":"20","author":"Gruber","year":"2019","journal-title":"Nat Rev Genet"},{"key":"2026060820234059800_qzaf116-B14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41580-022-00507-5","article-title":"Context-specific regulation and function of mRNA alternative polyadenylation","volume":"23","author":"Mitschka","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026060820234059800_qzaf116-B15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrm.2016.116","article-title":"Alternative polyadenylation of mRNA precursors","volume":"18","author":"Tian","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026060820234059800_qzaf116-B16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13046-021-01852-7","article-title":"Alternative polyadenylation: methods, mechanism, function, and role in cancer","volume":"40","author":"Zhang","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"2026060820234059800_qzaf116-B17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2017.12.035","article-title":"Nudt21 controls cell fate by connecting alternative polyadenylation to chromatin signaling","volume":"172","author":"Brumbaugh","year":"2018","journal-title":"Cell"},{"key":"2026060820234059800_qzaf116-B18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13045-020-00927-w","article-title":"RNA-binding proteins in tumor progression","volume":"13","author":"Qin","year":"2020","journal-title":"J Hematol Oncol"},{"key":"2026060820234059800_qzaf116-B19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/imr.13018","article-title":"The three as: alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function","volume":"304","author":"Blake","year":"2021","journal-title":"Immunol Rev"},{"key":"2026060820234059800_qzaf116-B20","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/s41590-022-01314-y","article-title":"NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia","volume":"23","author":"Witkowski","year":"2022","journal-title":"Nat Immunol"},{"key":"2026060820234059800_qzaf116-B21","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1038\/ncomms6274","article-title":"Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3\u2032-UTR landscape across seven tumour types","volume":"5","author":"Xia","year":"2014","journal-title":"Nat Commun"},{"key":"2026060820234059800_qzaf116-B22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-018-0465-8","article-title":"Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia","volume":"561","author":"Lee","year":"2018","journal-title":"Nature"},{"key":"2026060820234059800_qzaf116-B23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/jnci\/djx223","article-title":"Comprehensive characterization of alternative polyadenylation in human cancer","volume":"110","author":"Xiang","year":"2018","journal-title":"J Natl Cancer Inst"},{"key":"2026060820234059800_qzaf116-B24","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1038\/s41423-024-01237-8","article-title":"Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway","volume":"21","author":"Chen","year":"2024","journal-title":"Cell Mol Immunol"},{"key":"2026060820234059800_qzaf116-B25","doi-asserted-by":"crossref","first-page":"10531","DOI":"10.7150\/thno.40944","article-title":"Dissecting the heterogeneity of the alternative polyadenylation profiles in triple-negative breast cancers","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"2026060820234059800_qzaf116-B26","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1158\/0008-5472.CAN-16-0844","article-title":"Alternative polyadenylation in triple-negative breast tumors allows NRAS and c-JUN to bypass PUMILIO posttranscriptional regulation","volume":"76","author":"Miles","year":"2016","journal-title":"Cancer Res"},{"key":"2026060820234059800_qzaf116-B27","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1016\/j.molcel.2022.06.031","article-title":"Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1","volume":"82","author":"Song","year":"2022","journal-title":"Mol Cell"},{"key":"2026060820234059800_qzaf116-B28","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.stem.2020.03.003","article-title":"Differential alternative polyadenylation landscapes mediate hematopoietic stem cell activation and regulate glutamine metabolism","volume":"26","author":"Sommerkamp","year":"2020","journal-title":"Cell Stem Cell"},{"key":"2026060820234059800_qzaf116-B29","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1128\/MCB.01683-13","article-title":"Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation","volume":"34","author":"Kini","year":"2014","journal-title":"Mol Cell Biol"},{"key":"2026060820234059800_qzaf116-B30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mod.2015.02.003","article-title":"AUF-1 and YB-1 independently regulate \u03b2-globin mRNA in developing erythroid cells through interactions with poly(A)-binding protein","volume":"136","author":"van Zalen","year":"2015","journal-title":"Mech Dev"},{"key":"2026060820234059800_qzaf116-B31","doi-asserted-by":"crossref","first-page":"D1027","DOI":"10.1093\/nar\/gkx892","article-title":"TC3A: The Cancer 3\u2032 UTR Atlas","volume":"46","author":"Feng","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2026060820234059800_qzaf116-B32","doi-asserted-by":"crossref","first-page":"12425","DOI":"10.1093\/nar\/gkac878","article-title":"Human histone pre-mRNA assembles histone or canonical mRNA-processing complexes by overlapping 3\u2032-end sequence elements","volume":"50","author":"Ielasi","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2026060820234059800_qzaf116-B33","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1101\/gr.222331.117","article-title":"Comparative analysis of alternative polyadenylation in S. cerevisiae and S. pombe","volume":"27","author":"Liu","year":"2017","journal-title":"Genome Res"},{"key":"2026060820234059800_qzaf116-B34","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1101\/gr.10.7.1001","article-title":"Patterns of variant polyadenylation signal usage in human genes","volume":"10","author":"Beaudoing","year":"2000","journal-title":"Genome Res"},{"key":"2026060820234059800_qzaf116-B35","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1038\/s41467-022-30525-y","article-title":"Enhancers regulate 3\u2032 end processing activity to control expression of alternative 3\u2032 UTR isoforms","volume":"13","author":"Kwon","year":"2022","journal-title":"Nat Commun"},{"key":"2026060820234059800_qzaf116-B36","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1042\/BST20221128","article-title":"The emerging theme of 3\u2032 UTR mRNA isoform regulation in reprogramming of cell metabolism","volume":"51","author":"Zhang","year":"2023","journal-title":"Biochem Soc Trans"},{"key":"2026060820234059800_qzaf116-B37","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1038\/s41467-021-25388-8","article-title":"The landscape of alternative polyadenylation in single cells of the developing mouse embryo","volume":"12","author":"Agarwal","year":"2021","journal-title":"Nat Commun"},{"key":"2026060820234059800_qzaf116-B38","doi-asserted-by":"crossref","first-page":"e1005166","DOI":"10.1371\/journal.pgen.1005166","article-title":"Systematic profiling of poly(A)+ transcripts modulated by core 3\u2032 end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation","volume":"11","author":"Li","year":"2015","journal-title":"PLoS Genet"},{"key":"2026060820234059800_qzaf116-B39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13046-022-02339-9","article-title":"PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p","volume":"41","author":"Zhang","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"2026060820234059800_qzaf116-B40","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1042\/BST20150171","article-title":"Poly(A)-binding proteins and mRNA localization: who rules the roost?","volume":"43","author":"Gray","year":"2015","journal-title":"Biochem Soc Trans"},{"key":"2026060820234059800_qzaf116-B41","doi-asserted-by":"crossref","first-page":"22803","DOI":"10.1074\/jbc.M109.018226","article-title":"Poly(A) tail length is controlled by the nuclear poly(A)-binding protein regulating the interaction between poly(A) polymerase and the cleavage and polyadenylation specificity factor","volume":"284","author":"K\u00fchn U, G\u00fcndel M","year":"2009","journal-title":"J Biol Chem"},{"key":"2026060820234059800_qzaf116-B42","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1093\/hmg\/ddp569","article-title":"Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis","volume":"19","author":"Apponi","year":"2010","journal-title":"Hum Mol Genet"},{"key":"2026060820234059800_qzaf116-B43","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nbt.3423","article-title":"Three decades of nanopore sequencing","volume":"34","author":"Deamer","year":"2016","journal-title":"Nat Biotechnol"},{"key":"2026060820234059800_qzaf116-B44","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s41587-021-01108-x","article-title":"Nanopore sequencing technology, bioinformatics and applications","volume":"39","author":"Wang","year":"2021","journal-title":"Nat Biotechnol"},{"key":"2026060820234059800_qzaf116-B45","doi-asserted-by":"crossref","first-page":"18349","DOI":"10.1002\/jcp.28468","article-title":"The interplay between TGF-\u03b2-stimulated TSC22 domain family proteins regulates cell-cycle dynamics in medulloblastoma cells","volume":"234","author":"Dragotto","year":"2019","journal-title":"J Cell Physiol"},{"key":"2026060820234059800_qzaf116-B46","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1111\/febs.12123","article-title":"Multiple TSC22D4 iso-\/phospho-glycoforms display idiosyncratic subcellular localizations and interacting protein partners","volume":"280","author":"Canterini","year":"2013","journal-title":"FEBS J"},{"key":"2026060820234059800_qzaf116-B47","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41420-022-01049-7","article-title":"RNA-binding protein MEX3D promotes cervical carcinoma tumorigenesis by destabilizing TSC22D1 mRNA","volume":"8","author":"Zheng","year":"2022","journal-title":"Cell Death Discov"},{"key":"2026060820234059800_qzaf116-B48","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41419-023-05862-5","article-title":"The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1\/PAK1 modulation","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis"},{"key":"2026060820234059800_qzaf116-B49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijsu.2020.10.004","article-title":"Expression and prognostic roles of PABPC1 in hepatocellular carcinoma","volume":"84","author":"Zhu","year":"2020","journal-title":"Int J Surg"},{"key":"2026060820234059800_qzaf116-B50","doi-asserted-by":"crossref","first-page":"1025291","DOI":"10.3389\/fonc.2022.1025291","article-title":"PABPC1\u2013mRNA stability, protein translation and tumorigenesis","volume":"12","author":"Qi","year":"2022","journal-title":"Front Oncol"},{"key":"2026060820234059800_qzaf116-B51","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1038\/sj.leu.2404883","article-title":"Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD","volume":"21","author":"Lu","year":"2007","journal-title":"Leukemia"},{"key":"2026060820234059800_qzaf116-B52","doi-asserted-by":"crossref","first-page":"qzaf072","DOI":"10.1093\/gpbjnl\/qzaf072","article-title":"The GSA family in 2025: a broadened sharing platform for multi-omics and multimodal data","volume":"23","author":"Zhang","year":"2025","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"2026060820234059800_qzaf116-B53"}],"container-title":["Genomics, Proteomics &amp; Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzaf116\/65500522\/qzaf116.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/article-pdf\/23\/6\/qzaf116\/65500522\/qzaf116.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/article-pdf\/23\/6\/qzaf116\/65500522\/qzaf116.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:23:55Z","timestamp":1780964635000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gpb\/article\/doi\/10.1093\/gpbjnl\/qzaf116\/8342443"}},"subtitle":[],"editor":[{"given":"Yi","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12,22]]}},"URL":"https:\/\/doi.org\/10.1093\/gpbjnl\/qzaf116","relation":{},"ISSN":["1672-0229","2210-3244"],"issn-type":[{"value":"1672-0229","type":"print"},{"value":"2210-3244","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,11,25]]},"article-number":"qzaf116"}}