{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:36:49Z","timestamp":1787636209627,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Urinary proteomics has swiftly emerged as a formidable tool for the identification of non-invasive biomarkers and the surveillance of diseases. The progression in high-resolution mass spectrometry and data-independent acquisition techniques has facilitated the urinary proteome in providing detailed insights into intricate pathophysiological processes impacting multiple organ systems. This review synthesizes the recent advancements in urinary proteomics, detailing the analytical methodologies utilized, the challenges associated with standardization, and the normalization strategies crucial to the discipline. We undertake a comparative analysis of data-dependent and data-independent acquisition methodologies and examine their complementary roles in clinical workflows for biomarker discovery and translation. Additionally, we highlight both common and disease-specific proteomic signatures across a spectrum of disorders, including oncological, renal, cardiovascular, metabolic, and neurodegenerative diseases. We also investigate the role of artificial intelligence and multi-omics integration in supporting predictive modeling. Lastly, we discuss the ongoing developments in regulatory and implementation frameworks, such as data privacy regulations and clinical validation standards, that are positioning urinary proteomics as a key component of preventive and precision medicine.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzag028","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T17:01:43Z","timestamp":1776963703000},"source":"Crossref","is-referenced-by-count":1,"title":["Urinary Proteomics: Biological Foundations, Analytical Frameworks, and Clinical Translation Across Human Diseases"],"prefix":"10.1093","author":[{"given":"Fanjie","family":"Meng","sequence":"first","affiliation":[{"name":"Capital Medical University Department of Thoracic Surgery, Beijing Chao Yang Hospital, , Beijing 100020,","place":["China"]},{"name":"Capital Medical University Beijing Institute of Respiratory Medicine, , Beijing 100020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital Department of Thoracic Surgery, , Beijing 100044,","place":["China"]},{"name":"Peking University People\u2019s Hospital Thoracic Oncology Institute, , Beijing 100044,","place":["China"]},{"name":"Chinese Academy of Medical Sciences, 2021RU002, Peking University People\u2019s Hospital Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer, , Beijing 100044,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincheng","family":"Li","sequence":"additional","affiliation":[{"name":"Capital Medical University Department of Thoracic Surgery, Beijing Chao Yang Hospital, , Beijing 100020,","place":["China"]},{"name":"Capital Medical University Beijing Institute of Respiratory Medicine, , Beijing 100020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Pineal Diagnostics Co., Ltd ., Beijing 102206,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[{"name":"Capital Medical University Department of Thoracic Surgery, Beijing Chao Yang Hospital, , Beijing 100020,","place":["China"]},{"name":"Capital Medical University Beijing Institute of Respiratory Medicine, , Beijing 100020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital Department of Thoracic Surgery, , Beijing 100044,","place":["China"]},{"name":"Peking University People\u2019s Hospital Thoracic Oncology Institute, , Beijing 100044,","place":["China"]},{"name":"Chinese Academy of Medical Sciences, 2021RU002, Peking University People\u2019s Hospital Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer, , Beijing 100044,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital Department of Thoracic Surgery, , Beijing 100044,","place":["China"]},{"name":"Peking University People\u2019s Hospital Thoracic Oncology Institute, , Beijing 100044,","place":["China"]},{"name":"Chinese Academy of Medical Sciences, 2021RU002, Peking University People\u2019s Hospital Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer, , Beijing 100044,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,22]]},"container-title":["Genomics, Proteomics &amp; Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzag028\/68143775\/qzag028.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzag028\/68143775\/qzag028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T17:01:44Z","timestamp":1776963704000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article\/doi\/10.1093\/gpbjnl\/qzag028\/8661463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/gpbjnl\/qzag028","relation":{},"ISSN":["1672-0229","2210-3244"],"issn-type":[{"value":"1672-0229","type":"print"},{"value":"2210-3244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"article-number":"qzag028"}}