{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:21:16Z","timestamp":1776849676927,"version":"3.51.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Caloric restriction (CR) improves metabolic health and reduces the risk of aging-related vascular diseases. However, the systematic metabolic reprogramming associated with CR remains unclear. To address this, we performed multi-tissue metabolomic profiling (liver, heart, and serum) in apolipoprotein E-deficient (ApoE\u2212\/\u2212) mice subjected to CR. Metabolomic analyses of the multiple tissues revealed that glycerophospholipid metabolism pathway was consistently modulated by CR. To explore its relevance in vascular diseases, we performed serum metabolomic profiling in an abdominal aortic aneurysm (AAA) model induced by angiotensin \u2161 (Ang\u2161) infusion in ApoE\u2212\/\u2212 mice. The level of lysophosphatidylethanolamine (LPE) (16:0\/0:0), a metabolite in the glycerophospholipid metabolism pathway, was elevated during AAA progression and significantly reduced by CR intervention, suggesting its potential as a vascular disease risk factor. Notably, glycerophospholipid metabolism and LPE (16:0) were significantly associated with vascular diseases and aging-related indicators in human multi-omics data, including public transcriptomic and lipidomic, and our serum multi-omics profiling of 76 healthy aged individuals. Collectively, our findings establish glycerophospholipid metabolism and LPE (16:0) as systemic signatures of CR with diagnostic potential. They highlight a crucial link between systemic metabolism and vascular remodeling and remodeling-associated vascular diseases, while also functioning as indicators of systemic aging.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzag030","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:22:58Z","timestamp":1776846178000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabolomics Identified Caloric Restriction-associated Glycerophospholipid Alterations in ApoE\u2212\/\u2212 Mice"],"prefix":"10.1093","author":[{"given":"Zi-Yu","family":"Wei","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, , Beijing 100005,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, , Beijing 100005,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Tang","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health, Chinese Center for Disease Control and Prevention China CDC Key Laboratory of Environment and Population Health, , Beijing 100021,","place":["China"]},{"name":"National Institute of Environmental Health, Chinese Center for Disease Control and Prevention National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, , Beijing 100021,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, , Beijing 100005,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang-Jie","family":"Lv","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, , Beijing 100005,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, , Beijing 100005,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Fei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, , Beijing 100005,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College Department of Endocrinology, National Health Committee Key Laboratory of Endocrinology, Peking Union Medical College Hospital, , Beijing, 100730,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, , Beijing 100730,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoman","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, , Beijing 100005,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Shi","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health, Chinese Center for Disease Control and Prevention China CDC Key Laboratory of Environment and Population Health, , Beijing 100021,","place":["China"]},{"name":"National Institute of Environmental Health, Chinese Center for Disease Control and Prevention National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, , Beijing 100021,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Pei","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, , Beijing 100005,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hou-Zao","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, , Beijing 100005,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,21]]},"container-title":["Genomics, Proteomics &amp; Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzag030\/68133319\/qzag030.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzag030\/68133319\/qzag030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:22:59Z","timestamp":1776846179000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article\/doi\/10.1093\/gpbjnl\/qzag030\/8660620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/gpbjnl\/qzag030","relation":{},"ISSN":["1672-0229","2210-3244"],"issn-type":[{"value":"1672-0229","type":"print"},{"value":"2210-3244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"article-number":"qzag030"}}