{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:05:31Z","timestamp":1785182731062,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CVTree is an alignment-free methodology for inferring species phylogeny and taxonomy. This method allows for the efficient and accurate resolution of evolutionary relationships among large numbers of species based on whole-genome sequencing data. Since 2004, we have been continuously providing CVTree web services. Recently, the server has undergone a significant upgrade, culminating in the release of the WebCVTree4 platform. This upgrade involves a comprehensive update of the built-in genomic database. The core algorithm has been optimized to enable online phylogenetic reconstruction for tens of thousands of species, thereby facilitating the construction of whole-genome-based trees of life. Furthermore, we have developed a novel algorithm for comparing phylogenetic trees with established taxonomic systems, which supports rapid tree rooting, taxonomic annotation, and topology comparison. Additionally, the interactive front-end of the web interface has been enhanced to allow users to dynamically adjust tree layouts and export high-quality phylogenetic tree figures. These advancements enable WebCVTree4 to facilitate comprehensive comparative analyses that integrate whole-genome-based phylogenetic inference with taxonomy. As research in microbial evolution and taxonomy becomes increasingly dependent upon whole-genome data, WebCVTree4 will function as an efficient web-based platform to facilitate investigations in microbial phylogenetics and taxonomy. It is accessible at https:\/\/cvtree.online\/.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzag070","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:39:42Z","timestamp":1785181182000},"source":"Crossref","is-referenced-by-count":0,"title":["WebCVTree4: Phylogenetic and Taxonomic Study Platform for Prokaryotes base on Whole Genomes"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7822-5969","authenticated-orcid":false,"given":"Guanghong","family":"Zuo","sequence":"first","affiliation":[{"name":"University of Chinese Academy of Sciences Wenzhou Institute, , Wenzhou, Zhejiang 325001,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,27]]},"container-title":["Genomics, Proteomics &amp; Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzag070\/70184836\/qzag070.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzag070\/70184836\/qzag070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:39:43Z","timestamp":1785181183000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article\/doi\/10.1093\/gpbjnl\/qzag070\/8743614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/gpbjnl\/qzag070","relation":{},"ISSN":["1672-0229","2210-3244"],"issn-type":[{"value":"1672-0229","type":"print"},{"value":"2210-3244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"article-number":"qzag070"}}