{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:12:07Z","timestamp":1788613927575,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The increasing volume and complexity of biomedical data, especially driven by high-throughput biotechnologies, have highlighted the need for scalable, interoperable, and reproducible data analysis frameworks. While cloud computing has revolutionized data processing and collaboration in life sciences, challenges remain in building cloud platforms tailored to biomedical research and ensuring platform interoperability. To address these limitations, we propose Bio-OS, an open-source, cloud-native framework designed to support the rapid development of interoperable biomedical cloud platforms. Bio-OS aligns with the Global Alliance for Genomics and Health (GA4GH) cloud workstream standards\u2013including Workflow Execution Service (WES), Task Execution Service (TES), Data Repository Service (DRS), and Tool Registry Service (TRS) \u2014 while introducing innovations such as interactive execution models, workspace-centric data management, and AI-driven enhancements. These features facilitate adherence to the FAIR (Findable, Accessible, Interoperable, and Reusable) principles, promoting reproducibility and collaboration in biomedical research. Deployments across multiple research institutions demonstrated Bio-OS\u2019s ability to build biomedical cloud platforms and validated its efficacy in supporting data-intensive applications in life sciences.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzag085","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:47:13Z","timestamp":1787291233000},"source":"Crossref","is-referenced-by-count":0,"title":["Bio-OS: An Integrated Cloud-native Environment for Data-Intensive Biomedical Research"],"prefix":"10.1093","author":[{"given":"Jilong","family":"Liu","sequence":"first","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]},{"name":"The Chinese University of Hong Kong , Shenzhen 518172,","place":["China"]},{"name":"Shenzhen Research Institute of Big Data , Shenzhen 518172,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguang","family":"Yang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences Shanghai Institute of Nutrition and Health, , Shanghai 200030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Wang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center , China National Center for Bioinformation, Beijing 100049,","place":["China"]},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences, Chinese Academy of Sciences Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, , Shanghai 200031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences Center for Biomedical Information Technology, Shenzhen Institute of Advanced Technology, , Shenzhen 518055,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengshen","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yao","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixin","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziru","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wan","sequence":"additional","affiliation":[{"name":"Shenzhen Research Institute of Big Data , Shenzhen 518172,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunghui","family":"Chang","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong , Shenzhen 518172,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences Center for Biomedical Information Technology, Shenzhen Institute of Advanced Technology, , Shenzhen 518055,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences, Chinese Academy of Sciences Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, , Shanghai 200031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Genomics Data Center , China National Center for Bioinformation, Beijing 100049,","place":["China"]},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences Shanghai Institute of Nutrition and Health, , Shanghai 200030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixue","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]},{"name":"Chinese Academy of Sciences Shanghai Institute of Nutrition and Health, , Shanghai 200030,","place":["China"]},{"name":"Guangzhou Medical University GZMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, , Guangzhou 511436,","place":["China"]},{"name":"Shanghai Jiao Tong University School of Life Sciences and Biotechnology, , Shanghai 200240,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,20]]},"container-title":["Genomics, Proteomics &amp; Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzag085\/70736814\/qzag085.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzag085\/70736814\/qzag085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:21:46Z","timestamp":1788610906000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article\/doi\/10.1093\/gpbjnl\/qzag085\/8767541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/gpbjnl\/qzag085","relation":{},"ISSN":["1672-0229","2210-3244"],"issn-type":[{"value":"1672-0229","type":"print"},{"value":"2210-3244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"article-number":"qzag085"}}