{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:04:29Z","timestamp":1790863469189,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), has regained its position as the world\u2019s leading killer among infectious diseases. Despite extensive research progress across epidemiology, diagnosis, drug development, treatment regimens, vaccines, drug resistance, virulence factors, and immune mechanisms, MTB-related knowledge remains fragmented across thousands of publications, limiting its application in research and clinical practice. To address this gap, we present MTB-KB, a literature-curated knowledgebase that systematically integrates high-impact findings from eight major sections of TB research. The current release contains 75,170 associations from 1246 publications, covering 18,439 entities standardized using authoritative databases and WHO\u2013endorsed classifications. A central feature is the interactive knowledge graph, which links cross-section associations to reveal and visualize MTB\u2013host interactions, treatment strategies, and vaccine development opportunities. MTB-KB also provides a user-friendly interface with browsing, advanced search, and statistical visualization. Overall, by consolidating dispersed MTB knowledge into a structured and accessible platform, MTB-KB provides a valuable resource for researchers, clinicians, and policymakers, supporting both basic and clinical TB research, enabling evidence-based TB prevention, diagnosis, and treatment, and contributing to global elimination efforts. MTB-KB is accessible at https:\/\/ngdc.cncb.ac.cn\/mtbkb\/.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzag102","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:39:31Z","timestamp":1790861971000},"source":"Crossref","is-referenced-by-count":0,"title":["MTB-KB: A Curated Knowledgebase of\n                    <i>Mycobacterium tuberculosis<\/i>\n                    Related Studies"],"prefix":"10.1093","author":[{"given":"Pan","family":"Li","sequence":"first","affiliation":[{"name":"China National Center for Bioinformation , Beijing 100101,","place":["China"]},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuidan","family":"Li","sequence":"additional","affiliation":[{"name":"China National Center for Bioinformation , Beijing 100101,","place":["China"]},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shenyang Pharmaceutical University School of Life Science and Bio-Pharmaceutics, , Shenyang 110016,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Sun","sequence":"additional","affiliation":[{"name":"Jilin University Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, , Changchun 130021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"China National Center for Bioinformation , Beijing 100101,","place":["China"]},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojing","family":"Fan","sequence":"additional","affiliation":[{"name":"China National Center for Bioinformation , Beijing 100101,","place":["China"]},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Yue","sequence":"additional","affiliation":[{"name":"China National Center for Bioinformation , Beijing 100101,","place":["China"]},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jilin University Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, , Changchun 130021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"China National Center for Bioinformation , Beijing 100101,","place":["China"]},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Luo","sequence":"additional","affiliation":[{"name":"Jilin University Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, , Changchun 130021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinying","family":"Han","sequence":"additional","affiliation":[{"name":"Jilin University Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, , Changchun 130021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairong","family":"Huang","sequence":"additional","affiliation":[{"name":"Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, , Beijing 101149,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adong","family":"Shen","sequence":"additional","affiliation":[{"name":"National Key Discipline of Pediatrics (Capital Medical University), Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University Key Laboratory of Major Diseases in Children, Ministry of Education, , Beijing 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