{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T10:53:19Z","timestamp":1764067999979,"version":"3.45.0"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Most states mandate clinicians to review prescription drug monitoring program (PDMP) databases before prescribing opioids, but the association with perioperative outcomes is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 2016-2019 Medicare claims for patients \u226565 undergoing surgery in 21 states that enacted PDMP use mandates in 2017-2018 vs states without mandates during 2016-2019. Procedure-level, difference-in-differences models adjusted for patient demographics, prior opioid use, mental health, prior substance use disorders, comorbidities, surgeon specialty, and procedure type. Outcomes included discharge opioid prescriptions, days supplied, total and daily morphine milligram equivalents, high-risk prescribing (\u22657-day supply or opioid-benzodiazepine overlap), and 30-day post-discharge adverse events (overdose, emergency department visit, hospitalization, or death).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 597 455 procedures for 462 290 patients (mean age 73.3 years; 54.5% female), mandates were not associated with changes in opioid prescribing, high-risk prescribing, or adverse events (difference-in-differences estimate: \u22120.03% points, 95% CI: \u22121.0, 0.9). Findings were consistent among patients with prior substance use or in states with stringent mandates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PDMP use mandates were not associated with changes in perioperative opioid prescribing or post-surgical adverse events, suggesting that policymakers should consider pairing mandates with evidence-based, procedure-specific prescribing guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/haschl\/qxaf218","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:55:54Z","timestamp":1762865754000},"source":"Crossref","is-referenced-by-count":0,"title":["Prescription drug monitoring programs and perioperative opioid prescribing and adverse events"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5773-2187","authenticated-orcid":false,"given":"Joanne","family":"Constantin","sequence":"first","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109 ,","place":["United States"]},{"name":"Department of Health Policy and Management, School of Public Health, State University of New York (SUNY) Downstate Health Sciences University , Brooklyn, NY 11203 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Waljee","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Indiana University School of Medicine , Indianapolis, IN 46202, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-6925","authenticated-orcid":false,"given":"Thuy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Health Management and Policy, University of Michigan School of Public Health , Ann Arbor, MI 48109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Bohnert","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109 ,","place":["United States"]},{"name":"Opioid Research Institute, Office of the Vice President for Research, University of Michigan , Ann Arbor, MI 48109 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5484-6839","authenticated-orcid":false,"given":"Usha","family":"Nuliyalu","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad M","family":"Brummett","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109 ,","place":["United States"]},{"name":"Opioid Research Institute, Office of the Vice President for Research, University of Michigan , Ann Arbor, MI 48109 ,","place":["United States"]},{"name":"Overdose Prevention Engagement Network, University of Michigan Medical School , Ann Arbor, MI 48109 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-272X","authenticated-orcid":false,"given":"Kao-Ping","family":"Chua","sequence":"additional","affiliation":[{"name":"Susan B. 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