{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:09:12Z","timestamp":1790255352747,"version":"4.1.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The US Department of Health and Human Services\u2019 (HHS) \u201cMake America Healthy Again\u201d initiative cannot eradicate the root causes of the nation's chronic disease epidemic without tackling cigarette smoking, which kills over 480 000 Americans and costs $600 billion annually. This commentary reinvigorates a pivotal 2017 FDA framework by urging the current administration to finalize the proposed rule establishing a maximum nicotine cap in all cigarettes and selected combusted tobacco. Evidence demonstrates that capping nicotine at nonaddictive levels (\u223c95% reduction) rapidly decreases dependence and accelerates smoking cessation. The FDA projects that a nicotine cap will prevent 4.3 million smoking-related deaths by 2100 while saving $1.1 trillion annually in healthcare and productivity costs over 40 years. To maximize these gains, we outline 2 supporting strategies. First, the administration must substantially fund the nation's under-resourced smoking cessation infrastructure to meet the inevitable surge in quitting. Second, provide adults who smoke evidence-based information on the full spectrum of quitting smoking options by communicating the tobacco\/nicotine continuum of risk, that is, that combusted products (eg, cigarette) carry the greatest risk of disease, non-combusted products (eg, e-cigarettes) are likely to pose less risk than cigarettes, and medicinal nicotine products (eg, patches) are the safest option.<\/jats:p>","DOI":"10.1093\/haschl\/qxag239","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:20:06Z","timestamp":1788420006000},"source":"Crossref","is-referenced-by-count":0,"title":["Implementing a nicotine cap to make America Healthy Again"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-9515","authenticated-orcid":false,"given":"Dana Mowls","family":"Carroll","sequence":"first","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota , Minneapolis, MN 55455 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1108-2609","authenticated-orcid":false,"given":"Dorothy K","family":"Hatsukami","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota , Minneapolis, MN 55455 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia A","family":"Wackowski","sequence":"additional","affiliation":[{"name":"Rutgers Institute for Nicotine & Tobacco Studies, Rutgers University , New Brunswick, NJ 08901 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-980X","authenticated-orcid":false,"given":"Francis Joseph","family":"McClernon","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine Department of Psychiatry and Behavioral Sciences, , Durham, NC 27710 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3288-9652","authenticated-orcid":false,"given":"Eric","family":"Donny","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine Department of Translational Neuroscience, , Winston-Salem, NC 27157 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1461-6028","authenticated-orcid":false,"given":"Mitch","family":"Zeller","sequence":"additional","affiliation":[{"name":"Center for Tobacco Products, Food and Drug Administration , Silver Spring, MD 20993 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"2026092408515388000_qxag239-B1","author":"Norris"},{"key":"2026092408515388000_qxag239-B2","author":"Centers for Disease Control and 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