{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:04:25Z","timestamp":1775714665476,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tuberculosis (TB) treatment interruption undermines the effectiveness of TB medications and jeopardizes treatment outcomes. This study aimed to explore barriers, challenges, coping strategies and facilitators of TB treatment interruption to understand the treatment pathway in achieving successful outcomes. In-depth interviews were conducted at public health clinics in Sarawak, Malaysia, utilizing a phenomenological approach. Thirty patients who experienced TB treatment interruption with eventual successful treatment were purposively selected based on various reasons for treatment interruption to obtain diverse viewpoints. The audio-recorded transcriptions underwent thematic and content analysis. Five major themes emerged under barriers and challenges: socioeconomic, patient, therapy, healthcare and condition-related factors. Notably, financial burdens led individuals to prioritize work over health. Adverse drug reactions resulted in inappropriate self-medication and healthcare dissatisfaction. Medication error with suboptimal dosing was another facet leading to treatment forfeiture. Lack of knowledge about treatment duration and medication adherence, along with negative personal factors such as laziness, dishonesty and forgetfulness were reported. Participants employed coping strategies to confront barriers and challenges, including acceptance and commitment to disease and treatment, self-adaptation in mental, physical and social aspects, and self-management of minor adverse events. Fear of disease worsening, previous experiences, social and financial supports, along with intrinsic motivators, were essential facilitators that prevented interruptions. Interconnectivity across the explored dimensions contextualized the understanding of TB treatment interruption and offered valuable information for designing patient-centered intervention strategies. Improving patient education coupled with tailored interventions addressing psychosocial and economic barriers is crucial for ensuring TB treatment completion.<\/jats:p>","DOI":"10.1093\/heapro\/daae176","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T10:13:56Z","timestamp":1732529636000},"source":"Crossref","is-referenced-by-count":2,"title":["Tuberculosis treatment interruption: a qualitative exploration of barriers, challenges, coping strategies and facilitators in Malaysia"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4199-6743","authenticated-orcid":false,"given":"Ai Ling","family":"Oh","sequence":"first","affiliation":[{"name":"Centre of Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia , Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur ,","place":["Malaysia"]},{"name":"Department of Pharmacy, Sarawak General Hospital, Ministry of Health Malaysia , Jalan Tun Ahmad Zaidi Adruce, 93586 Kuching, Sarawak ,","place":["Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0592-0645","authenticated-orcid":false,"given":"Mohd","family":"Makmor-Bakry","sequence":"additional","affiliation":[{"name":"Centre of Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia , Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur ,","place":["Malaysia"]},{"name":"Faculty of Pharmacy, Universitas Airlangga , Jl. Mulyorejo, Mulyorejo, Surabaya, East Java 60115,","place":["Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-4361","authenticated-orcid":false,"given":"Farida","family":"Islahudin","sequence":"additional","affiliation":[{"name":"Centre of Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia , Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur ,","place":["Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7030-0971","authenticated-orcid":false,"given":"Chuo Yew","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Sarawak State Health, Ministry of Health Malaysia , Jalan Diplomatik, Off Jalan Bako, 93050 Kuching, Sarawak ,","place":["Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9800-0935","authenticated-orcid":false,"given":"Swee Kim","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine, Sarawak General Hospital, Ministry of Health Malaysia , Jalan Tun Ahmad Zaidi Adruce, 93586 Kuching, Sarawak ,","place":["Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2920-781X","authenticated-orcid":false,"given":"Siew Teck","family":"Tie","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine, Sarawak General Hospital, Ministry of Health Malaysia , Jalan Tun Ahmad Zaidi Adruce, 93586 Kuching, Sarawak ,","place":["Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"2024112510135214800_CIT0001","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1186\/s12889-021-10698-9","article-title":"Knowledge about tuberculosis, treatment 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